Abstract
Four recent publications reported the role of PD-L1 expression on host versus malignant cells within the tumor for PD-1/PD-L1 checkpoint blockade therapy. All four research groups harmoniously report: PD-L1 expressed by both host as well as tumor cells are capable of suppressing T cell functions. Thus, checkpoint therapy can be effective, if malignant cells do not express PD-L1.
| Original language | English |
|---|---|
| Article number | e1325982 |
| Journal | OncoImmunology |
| Volume | 6 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2017 |
| Externally published | Yes |