Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 239-243 |
| Journal | Journal of Pediatric Gastroenterology and Nutrition |
| Volume | 66 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2018 |
| Externally published | Yes |
Cite this
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Pediatric Gastroesophageal Reflux Disease: Systematic Review on Prognosis and Prognostic Factors. / Singendonk, Maartje M. J.; Tabbers, Merit M.; Benninga, Marc A.; Langendam, Miranda W.
In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 66, No. 2, 2018, p. 239-243.Research output: Contribution to journal › Review article › Academic › peer-review
TY - JOUR
T1 - Pediatric Gastroesophageal Reflux Disease: Systematic Review on Prognosis and Prognostic Factors
AU - Singendonk, Maartje M. J.
AU - Tabbers, Merit M.
AU - Benninga, Marc A.
AU - Langendam, Miranda W.
PY - 2018
Y1 - 2018
N2 - In this systematic review, we summarize the evidence on prognosis and prognostic factors of pediatric gastroesophageal reflux disease (GERD). A structured search of Embase and MEDLINE/PubMed (inception to April 2016) yielded 5365 references; 4 publications met our inclusion criteria (risk of bias moderate-high). Definitions and outcome measures varied widely between studies. The percentage of children with a diagnosis of GERD with esophagitis that had persisting symptoms and/or were on antireflux medication at follow-up (12 months to >5 years) ranged from 23% (weekly symptoms) to 68% (antireflux medication), depending on definition used. In children with a diagnosis of GERD without esophagitis, 1.4% developed esophagitis at follow-up (>5 years); none developed Barrett esophagus. In conclusion, prognostic studies on pediatric GERD are of limited quality and show large methodological heterogeneity. Based on these studies, we are unable to identify those children at risk for unfavorable outcome with regards to GERD symptoms or endoscopic complications.
AB - In this systematic review, we summarize the evidence on prognosis and prognostic factors of pediatric gastroesophageal reflux disease (GERD). A structured search of Embase and MEDLINE/PubMed (inception to April 2016) yielded 5365 references; 4 publications met our inclusion criteria (risk of bias moderate-high). Definitions and outcome measures varied widely between studies. The percentage of children with a diagnosis of GERD with esophagitis that had persisting symptoms and/or were on antireflux medication at follow-up (12 months to >5 years) ranged from 23% (weekly symptoms) to 68% (antireflux medication), depending on definition used. In children with a diagnosis of GERD without esophagitis, 1.4% developed esophagitis at follow-up (>5 years); none developed Barrett esophagus. In conclusion, prognostic studies on pediatric GERD are of limited quality and show large methodological heterogeneity. Based on these studies, we are unable to identify those children at risk for unfavorable outcome with regards to GERD symptoms or endoscopic complications.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85026479617&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/28753185
U2 - 10.1097/MPG.0000000000001697
DO - 10.1097/MPG.0000000000001697
M3 - Review article
VL - 66
SP - 239
EP - 243
JO - Journal of Pediatric Gastroenterology and Nutrition
JF - Journal of Pediatric Gastroenterology and Nutrition
SN - 0277-2116
IS - 2
ER -