Penile lesions and human papillomavirus in male sexual partners of women with cervical intraepithelial neoplasia

Maaike C G Bleeker, Cornelis J A Hogewoning, Adriaan J C Van Den Brule, Feja J Voorhorst, Rick E Van Andel, Elle K J Risse, Theo M Starink, Chris J L M Meijer

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND: Genital human papillomavirus infection (HPV) is causally associated with cervical carcinomas and premalignant lesions. Limited information is available about the prevalence of HPV and penile lesions in male sexual partners of women with cervical intraepithelial neoplasia (CIN).

OBJECTIVE: The aim of this study was to identify the presence of penile lesions and HPV in penile scrapings from male sexual partners of women with CIN.

METHODS: One hundred seventy-five male sexual partners of women with CIN were screened by peniscopy after acetowhite staining and HPV testing on penile scrapings.

RESULTS: Penile lesions were seen in 68% of the male sexual partners. More than one lesion type was diagnosed in 15%. Flat lesions, papular lesions, and condylomata acuminata were seen in 83%, 29%, and 4%, respectively. HPV was detected in 59% of the penile scrapings, containing mainly oncogenic HPV types. When penile lesions were present at peniscopy, 67% of penile scrapings were positive for HPV, whereas 37% were HPV-positive when no lesions were visible.

CONCLUSIONS: Penile lesions are frequently found in sexual partners of women with CIN. Most of these lesions are subclinical (ie, only visible after acetowhite staining) and are often associated with the presence of high-risk HPV, indicating that male sexual partners of women with CIN might constitute a reservoir for high-risk HPV.

Original languageEnglish
Pages (from-to)351-7
Number of pages7
JournalJournal of the American Academy of Dermatology
Volume47
Issue number3
Publication statusPublished - Sep 2002

Cite this

Bleeker, Maaike C G ; Hogewoning, Cornelis J A ; Van Den Brule, Adriaan J C ; Voorhorst, Feja J ; Van Andel, Rick E ; Risse, Elle K J ; Starink, Theo M ; Meijer, Chris J L M. / Penile lesions and human papillomavirus in male sexual partners of women with cervical intraepithelial neoplasia. In: Journal of the American Academy of Dermatology. 2002 ; Vol. 47, No. 3. pp. 351-7.
@article{b65c16a3f19c47f2b88442d2b05f1761,
title = "Penile lesions and human papillomavirus in male sexual partners of women with cervical intraepithelial neoplasia",
abstract = "BACKGROUND: Genital human papillomavirus infection (HPV) is causally associated with cervical carcinomas and premalignant lesions. Limited information is available about the prevalence of HPV and penile lesions in male sexual partners of women with cervical intraepithelial neoplasia (CIN).OBJECTIVE: The aim of this study was to identify the presence of penile lesions and HPV in penile scrapings from male sexual partners of women with CIN.METHODS: One hundred seventy-five male sexual partners of women with CIN were screened by peniscopy after acetowhite staining and HPV testing on penile scrapings.RESULTS: Penile lesions were seen in 68{\%} of the male sexual partners. More than one lesion type was diagnosed in 15{\%}. Flat lesions, papular lesions, and condylomata acuminata were seen in 83{\%}, 29{\%}, and 4{\%}, respectively. HPV was detected in 59{\%} of the penile scrapings, containing mainly oncogenic HPV types. When penile lesions were present at peniscopy, 67{\%} of penile scrapings were positive for HPV, whereas 37{\%} were HPV-positive when no lesions were visible.CONCLUSIONS: Penile lesions are frequently found in sexual partners of women with CIN. Most of these lesions are subclinical (ie, only visible after acetowhite staining) and are often associated with the presence of high-risk HPV, indicating that male sexual partners of women with CIN might constitute a reservoir for high-risk HPV.",
keywords = "Adult, Cervical Intraepithelial Neoplasia, Condylomata Acuminata, Female, Humans, Male, Middle Aged, Papillomaviridae, Papillomavirus Infections, Penis, Sexual Partners, Journal Article, Research Support, Non-U.S. Gov't",
author = "Bleeker, {Maaike C G} and Hogewoning, {Cornelis J A} and {Van Den Brule}, {Adriaan J C} and Voorhorst, {Feja J} and {Van Andel}, {Rick E} and Risse, {Elle K J} and Starink, {Theo M} and Meijer, {Chris J L M}",
year = "2002",
month = "9",
language = "English",
volume = "47",
pages = "351--7",
journal = "Journal of the American Academy of Dermatology",
issn = "0190-9622",
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number = "3",

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Penile lesions and human papillomavirus in male sexual partners of women with cervical intraepithelial neoplasia. / Bleeker, Maaike C G; Hogewoning, Cornelis J A; Van Den Brule, Adriaan J C; Voorhorst, Feja J; Van Andel, Rick E; Risse, Elle K J; Starink, Theo M; Meijer, Chris J L M.

In: Journal of the American Academy of Dermatology, Vol. 47, No. 3, 09.2002, p. 351-7.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Penile lesions and human papillomavirus in male sexual partners of women with cervical intraepithelial neoplasia

AU - Bleeker, Maaike C G

AU - Hogewoning, Cornelis J A

AU - Van Den Brule, Adriaan J C

AU - Voorhorst, Feja J

AU - Van Andel, Rick E

AU - Risse, Elle K J

AU - Starink, Theo M

AU - Meijer, Chris J L M

PY - 2002/9

Y1 - 2002/9

N2 - BACKGROUND: Genital human papillomavirus infection (HPV) is causally associated with cervical carcinomas and premalignant lesions. Limited information is available about the prevalence of HPV and penile lesions in male sexual partners of women with cervical intraepithelial neoplasia (CIN).OBJECTIVE: The aim of this study was to identify the presence of penile lesions and HPV in penile scrapings from male sexual partners of women with CIN.METHODS: One hundred seventy-five male sexual partners of women with CIN were screened by peniscopy after acetowhite staining and HPV testing on penile scrapings.RESULTS: Penile lesions were seen in 68% of the male sexual partners. More than one lesion type was diagnosed in 15%. Flat lesions, papular lesions, and condylomata acuminata were seen in 83%, 29%, and 4%, respectively. HPV was detected in 59% of the penile scrapings, containing mainly oncogenic HPV types. When penile lesions were present at peniscopy, 67% of penile scrapings were positive for HPV, whereas 37% were HPV-positive when no lesions were visible.CONCLUSIONS: Penile lesions are frequently found in sexual partners of women with CIN. Most of these lesions are subclinical (ie, only visible after acetowhite staining) and are often associated with the presence of high-risk HPV, indicating that male sexual partners of women with CIN might constitute a reservoir for high-risk HPV.

AB - BACKGROUND: Genital human papillomavirus infection (HPV) is causally associated with cervical carcinomas and premalignant lesions. Limited information is available about the prevalence of HPV and penile lesions in male sexual partners of women with cervical intraepithelial neoplasia (CIN).OBJECTIVE: The aim of this study was to identify the presence of penile lesions and HPV in penile scrapings from male sexual partners of women with CIN.METHODS: One hundred seventy-five male sexual partners of women with CIN were screened by peniscopy after acetowhite staining and HPV testing on penile scrapings.RESULTS: Penile lesions were seen in 68% of the male sexual partners. More than one lesion type was diagnosed in 15%. Flat lesions, papular lesions, and condylomata acuminata were seen in 83%, 29%, and 4%, respectively. HPV was detected in 59% of the penile scrapings, containing mainly oncogenic HPV types. When penile lesions were present at peniscopy, 67% of penile scrapings were positive for HPV, whereas 37% were HPV-positive when no lesions were visible.CONCLUSIONS: Penile lesions are frequently found in sexual partners of women with CIN. Most of these lesions are subclinical (ie, only visible after acetowhite staining) and are often associated with the presence of high-risk HPV, indicating that male sexual partners of women with CIN might constitute a reservoir for high-risk HPV.

KW - Adult

KW - Cervical Intraepithelial Neoplasia

KW - Condylomata Acuminata

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Papillomaviridae

KW - Papillomavirus Infections

KW - Penis

KW - Sexual Partners

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Article

VL - 47

SP - 351

EP - 357

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

SN - 0190-9622

IS - 3

ER -