Performance of using deformability of endometrial cells as a diagnostic test for endometriosis

Ahmad Altayyeb, Essam Othman, Maha Khashbah, Abdelhay Esmaeel, Mohamed El-Mokhtar, Cornelis Lambalk, Velja Mijatovic, Mohamed Abdelgawad*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

We present a microfluidic platform for less-invasive diagnosis of endometriosis based on measuring deformability of eutopic endometrial stromal cells. Primary endometrial cells from patients were found to travel inside a narrow microchannel at a significantly higher velocity (96.5 mm/s) compared to cells from disease free women (57.52 mm/s) (P value < 0.001). Using velocity of endometrial cells as a biomarker of endometriosis gave a sensitivity of 100%, and a specificity of 83%. Instead of doing a laparoscopic surgery, our test reduces cost of diagnosis of endometriosis to only few dollars with the proper setup.

Original languageEnglish
Title of host publication23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
PublisherChemical and Biological Microsystems Society
Pages1586-1587
Number of pages2
ISBN (Electronic)9781733419000
Publication statusPublished - 2019
Event23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland
Duration: 27 Oct 201931 Oct 2019

Publication series

Name23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019

Conference

Conference23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019
CountrySwitzerland
CityBasel
Period27/10/201931/10/2019

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