Perspectives for therapy in neurodegenerative disorders

Ruth Huizinga*, Sandra Amor

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review

Abstract

New insights into the mechanisms underlying immune-mediated neurodegenerative disorders indicate that therapeutic strategies should not only target the pathogenic immune response but also aid neuroprotection and neuronal repair. In this chapter we review the therapies that are currently used for neurodegenerative disorders including amyotrophic lateral sclerosis, Alzheimer's disease, brain trauma, multiple sclerosis, paraneoplastic neurodegenerative disorders and Parkinson's disease. We first focus on those approaches that target the immune response in disorders in which the immune responses has been shown to play a key role in the disease such as myasthenia gravis, paraneoplastic disorders and multiple sclerosis. In the second part the neuroprotective approaches are discussed including existing approved compounds as well as experimental approaches to treat these disorders.

Original languageEnglish
Title of host publicationAutoimmunity to Neuronal Proteins in Neurological Disorders
PublisherNOVA Science publishers, Inc.
Pages117-131
Number of pages15
ISBN (Print)9781613243978
Publication statusPublished - 1 Dec 2011

Cite this

Huizinga, R., & Amor, S. (2011). Perspectives for therapy in neurodegenerative disorders. In Autoimmunity to Neuronal Proteins in Neurological Disorders (pp. 117-131). NOVA Science publishers, Inc..