Perspectives of monoclonal antibodies for detection and treatment of head and neck tumours

J. Quak*, M. Gerretsen, R. De Bree, R. Brakenhof, G. Van Dongen, G. Snow

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Monoclonal antibodies (mabs) are potentially powerful tools for the detection and treatment of cancer. To date, only a limited number of mabs are available to head and neck cancer. We produced 5 different groups of mabs to head and neck cancer. These mabs were characterized for their reactivity tumour and non-tumour tissues. Furthermore, biochemical elucidation of recognized antigens was provided. In animal studies the effectiveness of mabs for diagnoses and therapy of cancer is clearly demonstrated. The first results of a clinical study for the detection of head and neck cancer with mabs are shown. Finally, the future of mabs in clinical oncology is discussed.

Original languageEnglish
Pages (from-to)2533-2539
Number of pages7
JournalAnticancer Research
Volume13
Issue number6 B
Publication statusPublished - 1 Dec 1993

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