Perspectives of monoclonal antibodies for detection and treatment of head and neck tumours

J. Quak, M. Gerretsen, R. De Bree, R. Brakenhof, G. Van Dongen, G. Snow

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Monoclonal antibodies (mabs) are potentially powerful tools for the detection and treatment of cancer. To date, only a limited number of mabs are available to head and neck cancer. We produced 5 different groups of mabs to head and neck cancer. These mabs were characterized for their reactivity tumour and non-tumour tissues. Furthermore, biochemical elucidation of recognized antigens was provided. In animal studies the effectiveness of mabs for diagnoses and therapy of cancer is clearly demonstrated. The first results of a clinical study for the detection of head and neck cancer with mabs are shown. Finally, the future of mabs in clinical oncology is discussed.

Original languageEnglish
Pages (from-to)2533-2539
Number of pages7
JournalAnticancer Research
Volume13
Issue number6 B
Publication statusPublished - 1 Dec 1993

Cite this

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title = "Perspectives of monoclonal antibodies for detection and treatment of head and neck tumours",
abstract = "Monoclonal antibodies (mabs) are potentially powerful tools for the detection and treatment of cancer. To date, only a limited number of mabs are available to head and neck cancer. We produced 5 different groups of mabs to head and neck cancer. These mabs were characterized for their reactivity tumour and non-tumour tissues. Furthermore, biochemical elucidation of recognized antigens was provided. In animal studies the effectiveness of mabs for diagnoses and therapy of cancer is clearly demonstrated. The first results of a clinical study for the detection of head and neck cancer with mabs are shown. Finally, the future of mabs in clinical oncology is discussed.",
keywords = "Head and neck tumours, Monoclonal antibodies",
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Perspectives of monoclonal antibodies for detection and treatment of head and neck tumours. / Quak, J.; Gerretsen, M.; De Bree, R.; Brakenhof, R.; Van Dongen, G.; Snow, G.

In: Anticancer Research, Vol. 13, No. 6 B, 01.12.1993, p. 2533-2539.

Research output: Contribution to journalArticleAcademicpeer-review

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T1 - Perspectives of monoclonal antibodies for detection and treatment of head and neck tumours

AU - Quak, J.

AU - Gerretsen, M.

AU - De Bree, R.

AU - Brakenhof, R.

AU - Van Dongen, G.

AU - Snow, G.

PY - 1993/12/1

Y1 - 1993/12/1

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AB - Monoclonal antibodies (mabs) are potentially powerful tools for the detection and treatment of cancer. To date, only a limited number of mabs are available to head and neck cancer. We produced 5 different groups of mabs to head and neck cancer. These mabs were characterized for their reactivity tumour and non-tumour tissues. Furthermore, biochemical elucidation of recognized antigens was provided. In animal studies the effectiveness of mabs for diagnoses and therapy of cancer is clearly demonstrated. The first results of a clinical study for the detection of head and neck cancer with mabs are shown. Finally, the future of mabs in clinical oncology is discussed.

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KW - Monoclonal antibodies

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