Phase-rectified signal averaging method to predict perinatal outcome in infants with very preterm fetal growth restriction- a secondary analysis of TRUFFLE-trial

Silvia M. Lobmaier, Nico Mensing van Charante, Enrico Ferrazzi, Dino A. Giussani, Caroline J. Shaw, Alexander Müller, Javier U. Ortiz, Eva Ostermayer, Bernhard Haller, Federico Prefumo, Tiziana Frusca, Kurt Hecher, Birgit Arabin, Baskaran Thilaganathan, Aris T. Papageorghiou, Amarnath Bhide, Pasquale Martinelli, Johannes J. Duvekot, Jim van Eyck, Gerard H.A. Visser & 13 others Georg Schmidt, Wessel Ganzevoort, Christoph C. Lees, Karl T.M. Schneider, Caterina M. Bilardo, Christoph Brezinka, Anke Diemert, Jan B. Derks, Dietmar Schlembach, Tullia Todros, Adriana Valcamonico, Neil Marlow, Aleid van Wassenaer-Leemhuis

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background Phase-rectified signal averaging, an innovative signal processing technique, can be used to investigate quasi-periodic oscillations in noisy, nonstationary signals that are obtained from fetal heart rate. Phase-rectified signal averaging is currently the best method to predict survival after myocardial infarction in adult cardiology. Application of this method to fetal medicine has established significantly better identification than with short-term variation by computerized cardiotocography of growth-restricted fetuses. Objective The aim of this study was to determine the longitudinal progression of phase-rectified signal averaging indices in severely growth-restricted human fetuses and the prognostic accuracy of the technique in relation to perinatal and neurologic outcome. Study Design Raw data from cardiotocography monitoring of 279 human fetuses were obtained from 8 centers that took part in the multicenter European “TRUFFLE” trial on optimal timing of delivery in fetal growth restriction. Average acceleration and deceleration capacities were calculated by phase-rectified signal averaging to establish progression from 5 days to 1 day before delivery and were compared with short-term variation progression. The receiver operating characteristic curves of average acceleration and deceleration capacities and short-term variation were calculated and compared between techniques for short- and intermediate-term outcome. Results Average acceleration and deceleration capacities and short-term variation showed a progressive decrease in their diagnostic indices of fetal health from the first examination 5 days before delivery to 1 day before delivery. However, this decrease was significant 3 days before delivery for average acceleration and deceleration capacities, but 2 days before delivery for short-term variation. Compared with analysis of changes in short-term variation, analysis of (delta) average acceleration and deceleration capacities better predicted values of Apgar scores <7 and antenatal death (area under the curve for prediction of antenatal death: delta average acceleration capacity, 0.62 [confidence interval, 0.19–1.0]; delta short-term variation, 0.54 [confidence interval, 0.13–0.97]; P=.006; area under the curve for prediction Apgar <7: average deceleration capacity <24 hours before delivery, 0.64 [confidence interval, 0.52–0.76]; short-term variation <24 hours before delivery, 0.53 [confidence interval, 0.40–0.65]; P=.015). Neither phase-rectified signal averaging indices nor short-term variation showed predictive power for developmental disability at 2 years of age (Bayley developmental quotient, <95 or <85). Conclusion The phase-rectified signal averaging method seems to be at least as good as short-term variation to monitor progressive deterioration of severely growth-restricted fetuses. Our findings suggest that for short-term outcomes such as Apgar score, phase-rectified signal averaging indices could be an even better test than short-term variation. Overall, our findings confirm the possible value of prospective trials based on phase-rectified signal averaging indices of autonomic nervous system of severely growth-restricted fetuses.

Original languageEnglish
Pages (from-to)630.e1-630.e7
JournalAmerican Journal of Obstetrics and Gynecology
Volume215
Issue number5
DOIs
Publication statusPublished - 1 Nov 2016

Cite this

Lobmaier, S. M., Mensing van Charante, N., Ferrazzi, E., Giussani, D. A., Shaw, C. J., Müller, A., ... van Wassenaer-Leemhuis, A. (2016). Phase-rectified signal averaging method to predict perinatal outcome in infants with very preterm fetal growth restriction- a secondary analysis of TRUFFLE-trial. American Journal of Obstetrics and Gynecology, 215(5), 630.e1-630.e7. https://doi.org/10.1016/j.ajog.2016.06.024
Lobmaier, Silvia M. ; Mensing van Charante, Nico ; Ferrazzi, Enrico ; Giussani, Dino A. ; Shaw, Caroline J. ; Müller, Alexander ; Ortiz, Javier U. ; Ostermayer, Eva ; Haller, Bernhard ; Prefumo, Federico ; Frusca, Tiziana ; Hecher, Kurt ; Arabin, Birgit ; Thilaganathan, Baskaran ; Papageorghiou, Aris T. ; Bhide, Amarnath ; Martinelli, Pasquale ; Duvekot, Johannes J. ; van Eyck, Jim ; Visser, Gerard H.A. ; Schmidt, Georg ; Ganzevoort, Wessel ; Lees, Christoph C. ; Schneider, Karl T.M. ; Bilardo, Caterina M. ; Brezinka, Christoph ; Diemert, Anke ; Derks, Jan B. ; Schlembach, Dietmar ; Todros, Tullia ; Valcamonico, Adriana ; Marlow, Neil ; van Wassenaer-Leemhuis, Aleid. / Phase-rectified signal averaging method to predict perinatal outcome in infants with very preterm fetal growth restriction- a secondary analysis of TRUFFLE-trial. In: American Journal of Obstetrics and Gynecology. 2016 ; Vol. 215, No. 5. pp. 630.e1-630.e7.
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title = "Phase-rectified signal averaging method to predict perinatal outcome in infants with very preterm fetal growth restriction- a secondary analysis of TRUFFLE-trial",
abstract = "Background Phase-rectified signal averaging, an innovative signal processing technique, can be used to investigate quasi-periodic oscillations in noisy, nonstationary signals that are obtained from fetal heart rate. Phase-rectified signal averaging is currently the best method to predict survival after myocardial infarction in adult cardiology. Application of this method to fetal medicine has established significantly better identification than with short-term variation by computerized cardiotocography of growth-restricted fetuses. Objective The aim of this study was to determine the longitudinal progression of phase-rectified signal averaging indices in severely growth-restricted human fetuses and the prognostic accuracy of the technique in relation to perinatal and neurologic outcome. Study Design Raw data from cardiotocography monitoring of 279 human fetuses were obtained from 8 centers that took part in the multicenter European “TRUFFLE” trial on optimal timing of delivery in fetal growth restriction. Average acceleration and deceleration capacities were calculated by phase-rectified signal averaging to establish progression from 5 days to 1 day before delivery and were compared with short-term variation progression. The receiver operating characteristic curves of average acceleration and deceleration capacities and short-term variation were calculated and compared between techniques for short- and intermediate-term outcome. Results Average acceleration and deceleration capacities and short-term variation showed a progressive decrease in their diagnostic indices of fetal health from the first examination 5 days before delivery to 1 day before delivery. However, this decrease was significant 3 days before delivery for average acceleration and deceleration capacities, but 2 days before delivery for short-term variation. Compared with analysis of changes in short-term variation, analysis of (delta) average acceleration and deceleration capacities better predicted values of Apgar scores <7 and antenatal death (area under the curve for prediction of antenatal death: delta average acceleration capacity, 0.62 [confidence interval, 0.19–1.0]; delta short-term variation, 0.54 [confidence interval, 0.13–0.97]; P=.006; area under the curve for prediction Apgar <7: average deceleration capacity <24 hours before delivery, 0.64 [confidence interval, 0.52–0.76]; short-term variation <24 hours before delivery, 0.53 [confidence interval, 0.40–0.65]; P=.015). Neither phase-rectified signal averaging indices nor short-term variation showed predictive power for developmental disability at 2 years of age (Bayley developmental quotient, <95 or <85). Conclusion The phase-rectified signal averaging method seems to be at least as good as short-term variation to monitor progressive deterioration of severely growth-restricted fetuses. Our findings suggest that for short-term outcomes such as Apgar score, phase-rectified signal averaging indices could be an even better test than short-term variation. Overall, our findings confirm the possible value of prospective trials based on phase-rectified signal averaging indices of autonomic nervous system of severely growth-restricted fetuses.",
keywords = "CTG, fetal growth restriction, phase-rectified signal averaging, PRSA, short-term variation, STV",
author = "Lobmaier, {Silvia M.} and {Mensing van Charante}, Nico and Enrico Ferrazzi and Giussani, {Dino A.} and Shaw, {Caroline J.} and Alexander M{\"u}ller and Ortiz, {Javier U.} and Eva Ostermayer and Bernhard Haller and Federico Prefumo and Tiziana Frusca and Kurt Hecher and Birgit Arabin and Baskaran Thilaganathan and Papageorghiou, {Aris T.} and Amarnath Bhide and Pasquale Martinelli and Duvekot, {Johannes J.} and {van Eyck}, Jim and Visser, {Gerard H.A.} and Georg Schmidt and Wessel Ganzevoort and Lees, {Christoph C.} and Schneider, {Karl T.M.} and Bilardo, {Caterina M.} and Christoph Brezinka and Anke Diemert and Derks, {Jan B.} and Dietmar Schlembach and Tullia Todros and Adriana Valcamonico and Neil Marlow and {van Wassenaer-Leemhuis}, Aleid",
year = "2016",
month = "11",
day = "1",
doi = "10.1016/j.ajog.2016.06.024",
language = "English",
volume = "215",
pages = "630.e1--630.e7",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "5",

}

Lobmaier, SM, Mensing van Charante, N, Ferrazzi, E, Giussani, DA, Shaw, CJ, Müller, A, Ortiz, JU, Ostermayer, E, Haller, B, Prefumo, F, Frusca, T, Hecher, K, Arabin, B, Thilaganathan, B, Papageorghiou, AT, Bhide, A, Martinelli, P, Duvekot, JJ, van Eyck, J, Visser, GHA, Schmidt, G, Ganzevoort, W, Lees, CC, Schneider, KTM, Bilardo, CM, Brezinka, C, Diemert, A, Derks, JB, Schlembach, D, Todros, T, Valcamonico, A, Marlow, N & van Wassenaer-Leemhuis, A 2016, 'Phase-rectified signal averaging method to predict perinatal outcome in infants with very preterm fetal growth restriction- a secondary analysis of TRUFFLE-trial' American Journal of Obstetrics and Gynecology, vol. 215, no. 5, pp. 630.e1-630.e7. https://doi.org/10.1016/j.ajog.2016.06.024

Phase-rectified signal averaging method to predict perinatal outcome in infants with very preterm fetal growth restriction- a secondary analysis of TRUFFLE-trial. / Lobmaier, Silvia M.; Mensing van Charante, Nico; Ferrazzi, Enrico; Giussani, Dino A.; Shaw, Caroline J.; Müller, Alexander; Ortiz, Javier U.; Ostermayer, Eva; Haller, Bernhard; Prefumo, Federico; Frusca, Tiziana; Hecher, Kurt; Arabin, Birgit; Thilaganathan, Baskaran; Papageorghiou, Aris T.; Bhide, Amarnath; Martinelli, Pasquale; Duvekot, Johannes J.; van Eyck, Jim; Visser, Gerard H.A.; Schmidt, Georg; Ganzevoort, Wessel; Lees, Christoph C.; Schneider, Karl T.M.; Bilardo, Caterina M.; Brezinka, Christoph; Diemert, Anke; Derks, Jan B.; Schlembach, Dietmar; Todros, Tullia; Valcamonico, Adriana; Marlow, Neil; van Wassenaer-Leemhuis, Aleid.

In: American Journal of Obstetrics and Gynecology, Vol. 215, No. 5, 01.11.2016, p. 630.e1-630.e7.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Phase-rectified signal averaging method to predict perinatal outcome in infants with very preterm fetal growth restriction- a secondary analysis of TRUFFLE-trial

AU - Lobmaier, Silvia M.

AU - Mensing van Charante, Nico

AU - Ferrazzi, Enrico

AU - Giussani, Dino A.

AU - Shaw, Caroline J.

AU - Müller, Alexander

AU - Ortiz, Javier U.

AU - Ostermayer, Eva

AU - Haller, Bernhard

AU - Prefumo, Federico

AU - Frusca, Tiziana

AU - Hecher, Kurt

AU - Arabin, Birgit

AU - Thilaganathan, Baskaran

AU - Papageorghiou, Aris T.

AU - Bhide, Amarnath

AU - Martinelli, Pasquale

AU - Duvekot, Johannes J.

AU - van Eyck, Jim

AU - Visser, Gerard H.A.

AU - Schmidt, Georg

AU - Ganzevoort, Wessel

AU - Lees, Christoph C.

AU - Schneider, Karl T.M.

AU - Bilardo, Caterina M.

AU - Brezinka, Christoph

AU - Diemert, Anke

AU - Derks, Jan B.

AU - Schlembach, Dietmar

AU - Todros, Tullia

AU - Valcamonico, Adriana

AU - Marlow, Neil

AU - van Wassenaer-Leemhuis, Aleid

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Background Phase-rectified signal averaging, an innovative signal processing technique, can be used to investigate quasi-periodic oscillations in noisy, nonstationary signals that are obtained from fetal heart rate. Phase-rectified signal averaging is currently the best method to predict survival after myocardial infarction in adult cardiology. Application of this method to fetal medicine has established significantly better identification than with short-term variation by computerized cardiotocography of growth-restricted fetuses. Objective The aim of this study was to determine the longitudinal progression of phase-rectified signal averaging indices in severely growth-restricted human fetuses and the prognostic accuracy of the technique in relation to perinatal and neurologic outcome. Study Design Raw data from cardiotocography monitoring of 279 human fetuses were obtained from 8 centers that took part in the multicenter European “TRUFFLE” trial on optimal timing of delivery in fetal growth restriction. Average acceleration and deceleration capacities were calculated by phase-rectified signal averaging to establish progression from 5 days to 1 day before delivery and were compared with short-term variation progression. The receiver operating characteristic curves of average acceleration and deceleration capacities and short-term variation were calculated and compared between techniques for short- and intermediate-term outcome. Results Average acceleration and deceleration capacities and short-term variation showed a progressive decrease in their diagnostic indices of fetal health from the first examination 5 days before delivery to 1 day before delivery. However, this decrease was significant 3 days before delivery for average acceleration and deceleration capacities, but 2 days before delivery for short-term variation. Compared with analysis of changes in short-term variation, analysis of (delta) average acceleration and deceleration capacities better predicted values of Apgar scores <7 and antenatal death (area under the curve for prediction of antenatal death: delta average acceleration capacity, 0.62 [confidence interval, 0.19–1.0]; delta short-term variation, 0.54 [confidence interval, 0.13–0.97]; P=.006; area under the curve for prediction Apgar <7: average deceleration capacity <24 hours before delivery, 0.64 [confidence interval, 0.52–0.76]; short-term variation <24 hours before delivery, 0.53 [confidence interval, 0.40–0.65]; P=.015). Neither phase-rectified signal averaging indices nor short-term variation showed predictive power for developmental disability at 2 years of age (Bayley developmental quotient, <95 or <85). Conclusion The phase-rectified signal averaging method seems to be at least as good as short-term variation to monitor progressive deterioration of severely growth-restricted fetuses. Our findings suggest that for short-term outcomes such as Apgar score, phase-rectified signal averaging indices could be an even better test than short-term variation. Overall, our findings confirm the possible value of prospective trials based on phase-rectified signal averaging indices of autonomic nervous system of severely growth-restricted fetuses.

AB - Background Phase-rectified signal averaging, an innovative signal processing technique, can be used to investigate quasi-periodic oscillations in noisy, nonstationary signals that are obtained from fetal heart rate. Phase-rectified signal averaging is currently the best method to predict survival after myocardial infarction in adult cardiology. Application of this method to fetal medicine has established significantly better identification than with short-term variation by computerized cardiotocography of growth-restricted fetuses. Objective The aim of this study was to determine the longitudinal progression of phase-rectified signal averaging indices in severely growth-restricted human fetuses and the prognostic accuracy of the technique in relation to perinatal and neurologic outcome. Study Design Raw data from cardiotocography monitoring of 279 human fetuses were obtained from 8 centers that took part in the multicenter European “TRUFFLE” trial on optimal timing of delivery in fetal growth restriction. Average acceleration and deceleration capacities were calculated by phase-rectified signal averaging to establish progression from 5 days to 1 day before delivery and were compared with short-term variation progression. The receiver operating characteristic curves of average acceleration and deceleration capacities and short-term variation were calculated and compared between techniques for short- and intermediate-term outcome. Results Average acceleration and deceleration capacities and short-term variation showed a progressive decrease in their diagnostic indices of fetal health from the first examination 5 days before delivery to 1 day before delivery. However, this decrease was significant 3 days before delivery for average acceleration and deceleration capacities, but 2 days before delivery for short-term variation. Compared with analysis of changes in short-term variation, analysis of (delta) average acceleration and deceleration capacities better predicted values of Apgar scores <7 and antenatal death (area under the curve for prediction of antenatal death: delta average acceleration capacity, 0.62 [confidence interval, 0.19–1.0]; delta short-term variation, 0.54 [confidence interval, 0.13–0.97]; P=.006; area under the curve for prediction Apgar <7: average deceleration capacity <24 hours before delivery, 0.64 [confidence interval, 0.52–0.76]; short-term variation <24 hours before delivery, 0.53 [confidence interval, 0.40–0.65]; P=.015). Neither phase-rectified signal averaging indices nor short-term variation showed predictive power for developmental disability at 2 years of age (Bayley developmental quotient, <95 or <85). Conclusion The phase-rectified signal averaging method seems to be at least as good as short-term variation to monitor progressive deterioration of severely growth-restricted fetuses. Our findings suggest that for short-term outcomes such as Apgar score, phase-rectified signal averaging indices could be an even better test than short-term variation. Overall, our findings confirm the possible value of prospective trials based on phase-rectified signal averaging indices of autonomic nervous system of severely growth-restricted fetuses.

KW - CTG

KW - fetal growth restriction

KW - phase-rectified signal averaging

KW - PRSA

KW - short-term variation

KW - STV

UR - http://www.scopus.com/inward/record.url?scp=84994474462&partnerID=8YFLogxK

U2 - 10.1016/j.ajog.2016.06.024

DO - 10.1016/j.ajog.2016.06.024

M3 - Article

VL - 215

SP - 630.e1-630.e7

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 5

ER -