Phosphorylation at endothelial cell-cell junctions: Implications for VE-cadherin function

Ilse Timmerman, Peter L. Hordijk, Jaap D. van Buul

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Endothelial cell-cell junctions are strictly regulated in order to control the barrier function of endothelium. Vascular endothelial (VE)-cadherin is one of the proteins that is crucial in this process. It has been reported that phosphorylation events control the function of VE-cadherin. This review summarizes the role of VE-cadherin phosphorylation in the regulation of endothelial cell-cell junctions and highlights how this affects vascular permeability and leukocyte extravasation.

Original languageEnglish
Pages (from-to)23-31
Number of pages9
JournalCell Health and Cytoskeleton
Volume2
Issue number1
Publication statusPublished - 23 Nov 2010

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