Gevolgen van depressie voor het lichamelijk functioneren en sterfte van ouderen. Longitudinale resultaten van het LASA-onderzoek

Translated title of the contribution: Physical health and mortality consequences of late-life depression: Results from the Longitudinal Aging Study Amsterdam

B. W J H Penninx*, A. T F Beekman, D. J H Deeg, W. Van Tilburg

*Corresponding author for this work

Research output: Contribution to journalArticleProfessional


This longitudinal study examines the physical health consequences of depression among 3107 older persons (55-85 years). Major depression was defined according to DSM-III criteria in a psychiatric interview. Minor depression was defined by a Center for Epidemiologic Studies Depression score ≥ 16. Health consequences were assessed by 3-year change in self-reported functional status, 3-year change in performance on objective tests, and risk of death over 4,5 years: At baseline, 12.8% of the older persons had minor depression and 2.0% major depression. Minor depression was associated with a significantly greater decline in functional status and performance and, only in men but not in women, with an increased risk of death. Major depression also increases decline in functional status and the risk of death (irrespective of sex), but was not associated with decline in physical performance. These results show that late-life depression has strong unfavorable physical health consequences. The consequences of minor depression are comparable with those of major depression.

Original languageDutch
Pages (from-to)211-218
Number of pages8
JournalTijdschrift voor Gerontologie en Geriatrie
Issue number5
Publication statusPublished - 1 Jan 2000

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