TY - JOUR
T1 - Pilot of a therapist-guided digital mental health intervention (eHealth CF-CBT) for adults with cystic fibrosis
AU - Verkleij, Marieke
AU - Georgiopoulos, Anna M.
AU - Barendrecht, Heleen
AU - Friedman, Deborah
N1 - Funding Information:
We thank the adults with CF who participated in the eHealth CF‐CBT program and provided valuable feedback. We also thank the Amsterdam UMC CF team for recruiting the participants, with special thanks to Rianne Lub and Josje Altenburg. We are grateful to Vertex Pharmaceuticals, Inc. and the Dutch Cystic Fibrosis Foundation for their support for developing and piloting eHealth CF‐CBT, and to the Cystic Fibrosis Foundation for supporting the development of CF‐CBT.
Funding Information:
This work was supported by the Corno grant of the Dutch Cystic Fibrosis Foundation and Vertex Pharmaceuticals, Inc. via Circle of Care charitable awards. The funding sources had no role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. Marieke Verkleij reports grants from the Dutch Cystic Fibrosis Foundation and Vertex Pharmaceuticals. Anna M. Georgiopoulos reports personal fees from Vertex Pharmaceuticals, outside the submitted work; grants, personal fees, travel reimbursement, and nonfinancial support from the Cystic Fibrosis Foundation (CFF), outside the submitted work; travel‐reimbursement from the European Cystic Fibrosis Society, outside the submitted work; personal fees from Saudi Pediatric Pulmonology Association, outside the submitted work; personal fees from Johns Hopkins University/DKBmed, outside the submitted work. Anna M. Georgiopoulos reports grants and travel reimbursement from the CFF.
Publisher Copyright:
© 2023 The Authors. Pediatric Pulmonology published by Wiley Periodicals LLC.
PY - 2023
Y1 - 2023
N2 - Background: eHealth CF-CBT is the first digital mental health intervention for depression/anxiety in adults with cystic fibrosis (awCF); an 8-session therapist-guided internet-delivered program that was developed in English and Dutch with stakeholder input and evaluation indicating high acceptability and usability. Methods: Dutch eHealth CF-CBT was piloted in awCF with mild-moderate symptoms of depression and/or anxiety. Feasibility, usability, acceptability, and preliminary efficacy were assessed, measuring pre-post changes in depression (PHQ-9), anxiety (GAD-7), perceived stress (PSS), and health-related quality of life (CFQ-R). Results: All participants (n = 10, seven female, mean age 29 [range 21–43], mean FEV1 71%pred [range 31–115]) completed all sessions. Patient-rated feasibility, usability, and acceptability of eHealth CF-CBT were positive on validated scales, as were qualitative assessments of content and format. GAD-7 improved in 90% of participants; in 50% by ≥the minimally important difference (MID) of four points. PHQ-9 improved in 90%; 40% by ≥the MID of 5. PSS improved in 80%. CFQ-R improved in the domain health perceptions (70%). Conclusions: eHealth CF-CBT demonstrated feasibility, usability, acceptability, and promising preliminary efficacy in this pilot trial with Dutch awCF with mild to moderate symptoms of depression and anxiety.
AB - Background: eHealth CF-CBT is the first digital mental health intervention for depression/anxiety in adults with cystic fibrosis (awCF); an 8-session therapist-guided internet-delivered program that was developed in English and Dutch with stakeholder input and evaluation indicating high acceptability and usability. Methods: Dutch eHealth CF-CBT was piloted in awCF with mild-moderate symptoms of depression and/or anxiety. Feasibility, usability, acceptability, and preliminary efficacy were assessed, measuring pre-post changes in depression (PHQ-9), anxiety (GAD-7), perceived stress (PSS), and health-related quality of life (CFQ-R). Results: All participants (n = 10, seven female, mean age 29 [range 21–43], mean FEV1 71%pred [range 31–115]) completed all sessions. Patient-rated feasibility, usability, and acceptability of eHealth CF-CBT were positive on validated scales, as were qualitative assessments of content and format. GAD-7 improved in 90% of participants; in 50% by ≥the minimally important difference (MID) of four points. PHQ-9 improved in 90%; 40% by ≥the MID of 5. PSS improved in 80%. CFQ-R improved in the domain health perceptions (70%). Conclusions: eHealth CF-CBT demonstrated feasibility, usability, acceptability, and promising preliminary efficacy in this pilot trial with Dutch awCF with mild to moderate symptoms of depression and anxiety.
KW - anxiety
KW - cognitive-behavioral therapy
KW - cystic fibrosis
KW - depression
KW - digital mental health
KW - psychotherapy
UR - http://www.scopus.com/inward/record.url?scp=85158139769&partnerID=8YFLogxK
U2 - 10.1002/ppul.26438
DO - 10.1002/ppul.26438
M3 - Article
C2 - 37144856
SN - 8755-6863
JO - Pediatric Pulmonology
JF - Pediatric Pulmonology
ER -