Abstract

Objective: Trauma in pregnancy may cause placental abruption. Consequences of moderate placental injury on neurodevelopment are unknown. The aim was to evaluate placental histology after maternal trauma. Methods: A prospective study was conducted at 2 tertiary medical centers in the Netherlands. Placentas from women exposed to maternal trauma ≥ 20 weeks’ gestational age were histologically examined. Neurological follow-up of the infants was performed at 1 year of age by means of Alberta Infant Motor Scale. Histological findings were compared to placentas from pregnancies without trauma. Principal Results: Thirteen placentas were investigated in the trauma group. The control group consisted of 15 placentas. Placental pathology was seen more often in the trauma cases (11 of the 13) than in the controls (6 of the 15), P =.024. Neurological follow-up was normal. Conclusions: In this small population, majority of the placentas showed pathology after minor trauma in pregnancy without consequences for neurodevelopment at 1 year.
LanguageEnglish
JournalPediatric and Developmental Pathology
DOIs
Publication statusE-pub ahead of print - 2018

Cite this

@article{5e3a7165020f4ee2a21e82dd8c34f995,
title = "Placental Histology After Minor Trauma in Pregnancy: A Pilot Study",
abstract = "Objective: Trauma in pregnancy may cause placental abruption. Consequences of moderate placental injury on neurodevelopment are unknown. The aim was to evaluate placental histology after maternal trauma. Methods: A prospective study was conducted at 2 tertiary medical centers in the Netherlands. Placentas from women exposed to maternal trauma ≥ 20 weeks’ gestational age were histologically examined. Neurological follow-up of the infants was performed at 1 year of age by means of Alberta Infant Motor Scale. Histological findings were compared to placentas from pregnancies without trauma. Principal Results: Thirteen placentas were investigated in the trauma group. The control group consisted of 15 placentas. Placental pathology was seen more often in the trauma cases (11 of the 13) than in the controls (6 of the 15), P =.024. Neurological follow-up was normal. Conclusions: In this small population, majority of the placentas showed pathology after minor trauma in pregnancy without consequences for neurodevelopment at 1 year.",
author = "{van der Knoop}, {B. J.} and {van der Voorn}, {J. P.} and Nikkels, {P. G. J.} and Zonnenberg, {I. A.} and {van Weissenbruch}, {M. M.} and Vermeulen, {R. J.} and {de Vries}, {J. I. P.}",
year = "2018",
doi = "10.1177/1093526618799292",
language = "English",
journal = "Pediatric and Developmental Pathology",
issn = "1093-5266",
publisher = "Society for Pediatric Pathology",

}

TY - JOUR

T1 - Placental Histology After Minor Trauma in Pregnancy: A Pilot Study

AU - van der Knoop, B. J.

AU - van der Voorn, J. P.

AU - Nikkels, P. G. J.

AU - Zonnenberg, I. A.

AU - van Weissenbruch, M. M.

AU - Vermeulen, R. J.

AU - de Vries, J. I. P.

PY - 2018

Y1 - 2018

N2 - Objective: Trauma in pregnancy may cause placental abruption. Consequences of moderate placental injury on neurodevelopment are unknown. The aim was to evaluate placental histology after maternal trauma. Methods: A prospective study was conducted at 2 tertiary medical centers in the Netherlands. Placentas from women exposed to maternal trauma ≥ 20 weeks’ gestational age were histologically examined. Neurological follow-up of the infants was performed at 1 year of age by means of Alberta Infant Motor Scale. Histological findings were compared to placentas from pregnancies without trauma. Principal Results: Thirteen placentas were investigated in the trauma group. The control group consisted of 15 placentas. Placental pathology was seen more often in the trauma cases (11 of the 13) than in the controls (6 of the 15), P =.024. Neurological follow-up was normal. Conclusions: In this small population, majority of the placentas showed pathology after minor trauma in pregnancy without consequences for neurodevelopment at 1 year.

AB - Objective: Trauma in pregnancy may cause placental abruption. Consequences of moderate placental injury on neurodevelopment are unknown. The aim was to evaluate placental histology after maternal trauma. Methods: A prospective study was conducted at 2 tertiary medical centers in the Netherlands. Placentas from women exposed to maternal trauma ≥ 20 weeks’ gestational age were histologically examined. Neurological follow-up of the infants was performed at 1 year of age by means of Alberta Infant Motor Scale. Histological findings were compared to placentas from pregnancies without trauma. Principal Results: Thirteen placentas were investigated in the trauma group. The control group consisted of 15 placentas. Placental pathology was seen more often in the trauma cases (11 of the 13) than in the controls (6 of the 15), P =.024. Neurological follow-up was normal. Conclusions: In this small population, majority of the placentas showed pathology after minor trauma in pregnancy without consequences for neurodevelopment at 1 year.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85059000811&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/30208758

U2 - 10.1177/1093526618799292

DO - 10.1177/1093526618799292

M3 - Article

JO - Pediatric and Developmental Pathology

T2 - Pediatric and Developmental Pathology

JF - Pediatric and Developmental Pathology

SN - 1093-5266

ER -