Plant‐derived extracellular vesicles: Current findings, challenges, and future applications

Nader Kameli, Anya Dragojlovic‐kerkache, Paul Savelkoul, Frank R. Stassen*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review


In recent years, plant‐derived extracellular vesicles (PDEVs) have gained the interest of many experts in fields such as microbiology and immunology, and research in this field has expo-nentially increased. These nano‐sized particles have provided researchers with a number of inter-esting findings, making their application in human health and disease very promising. Both in vitro and in vivo experiments have shown that PDEVs can exhibit a multitude of effects, suggesting that these vesicles may have many potential future applications, including therapeutics and nano‐deliv-ery of compounds. While the preliminary results are promising, there are still some challenges to face, such as a lack of protocol standardization, as well as knowledge gaps that need to be filled. This review aims to discuss various aspects of PDEV knowledge, including their preliminary find-ings, challenges, and future uses, giving insight into the complexity of conducting research in this field.
Original languageEnglish
Article number411
Issue number6
Publication statusPublished - 1 Jun 2021

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