Polygenic differential susceptibility to prenatal adversity

Jay Belsky, Irina Pokhvisneva, Anu Sathyan Sathyapalan Rema, Birit F P Broekman, Michael Pluess, Kieran J O'Donnell, Michael J Meaney, Patrícia P Silveira

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

A recent article in this journal reported a number of gene × environment interactions involving a serotonin transporter-gene network polygenic score and a composite index of prenatal adversity predicting several problem behavior outcomes at 48 months (e.g., anxious/depressed, pervasive developmental problems) and at 60 months (e.g., withdrawal, internalizing problems), yet did not illuminate the nature or form these genetic × environment interactions took. Here we report results of six additional analyses to evaluate whether these interactions reflected diathesis-stress or differential-susceptibility related processes. Analyses of the regions of significance and proportion of interaction index are consistent with the diathesis-stress model, seemingly because of the truncated nature of the adversity score (which did not extend to supportive/positive prenatal experiences/exposures); in contrast, the proportion (of cases) affected index favors the differential-susceptibility model. These results suggest the need for future studies to extend measurement of the prenatal environment to highly supportive experiences and exposures.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalDevelopment and Psychopathology
DOIs
Publication statusE-pub ahead of print - 7 Aug 2018
Externally publishedYes

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