Population pharmacokinetics with Monte Carlo simulations of gentamicin in a population of severely ill adult patients from sub-Saharan Africa

Jeannet C. Bos, Jan M. Prins, Mabor C. Mistício, Ginto Nunguiane, Cláudia N. Lang, José C. Beirão, Ron A. A. Mathôt, Reinier M. van Hest

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Abstract

In sub-Saharan Africa (SSA), gentamicin is commonly used for severe infections in non-intensive-care-unit (ICU) settings, but pharmacokinetic and pharmacodynamic data for this specific population are lacking. We performed a population pharmacokinetic study in an adult Mozambican non-ICU hospital population treated with gentamicin (n 48) and developed a pharmacokinetic model using nonlinear mixed-effects modeling. Simulations showed that non-ICU patient populations in SSA may be at substantial risk for underexposure to gentamicin during routine once-daily dosing.
Original languageEnglish
Article numbere02328-18
JournalAntimicrobial Agents and Chemotherapy
Volume63
Issue number4
DOIs
Publication statusPublished - 1 Apr 2019
Externally publishedYes

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