Abstract
In sub-Saharan Africa (SSA), gentamicin is commonly used for severe infections in non-intensive-care-unit (ICU) settings, but pharmacokinetic and pharmacodynamic data for this specific population are lacking. We performed a population pharmacokinetic study in an adult Mozambican non-ICU hospital population treated with gentamicin (n 48) and developed a pharmacokinetic model using nonlinear mixed-effects modeling. Simulations showed that non-ICU patient populations in SSA may be at substantial risk for underexposure to gentamicin during routine once-daily dosing.
Original language | English |
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Article number | e02328-18 |
Journal | Antimicrobial Agents and Chemotherapy |
Volume | 63 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Apr 2019 |
Externally published | Yes |