In sub-Saharan Africa (SSA), gentamicin is commonly used for severe infections in non-intensive-care-unit (ICU) settings, but pharmacokinetic and pharmacodynamic data for this specific population are lacking. We performed a population pharmacokinetic study in an adult Mozambican non-ICU hospital population treated with gentamicin (n 48) and developed a pharmacokinetic model using nonlinear mixed-effects modeling. Simulations showed that non-ICU patient populations in SSA may be at substantial risk for underexposure to gentamicin during routine once-daily dosing.
Bos, J. C., Prins, J. M., Mistício, M. C., Nunguiane, G., Lang, C. N., Beirão, J. C., ... van Hest, R. M. (2019). Population pharmacokinetics with Monte Carlo simulations of gentamicin in a population of severely ill adult patients from sub-Saharan Africa. Antimicrobial Agents and Chemotherapy, 63(4), [e02328-18]. https://doi.org/10.1128/AAC.02328-18