Precision medicine in cancer: challenges and recommendations from an EU-funded cervical cancer biobanking study

Sanne Samuels, Balazs Balint, Heiko von der Leyen, Philippe Hupé, Leanne de Koning, Choumouss Kamoun, Windy Luscap-Rondof, Ulrike Wittkop, Ksenia Bagrintseva, Marina Popovic, Atttila Kereszt, Els Berns, Gemma G Kenter, Ekaterina S Jordanova, Maud Kamal, Susy Scholl

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

BACKGROUND: Cervical cancer (CC) remains a leading cause of gynaecological cancer-related mortality worldwide. CC pathogenesis is triggered when human papillomavirus (HPV) inserts into the genome, resulting in tumour suppressor gene inactivation and oncogene activation. Collecting tumour and blood samples is critical for identifying these genetic alterations.

METHODS: BIO-RAIDs is the first prospective molecular profiling clinical study to include a substantial biobanking effort that used uniform high-quality standards and control of samples. In this European Union (EU)-funded study, we identified the challenges that were impeding the effective implementation of such a systematic and comprehensive biobanking effort.

RESULTS: The challenges included a lack of uniform international legal and ethical standards, complexities in clinical and molecular data management, and difficulties in determining the best technical platforms and data analysis techniques. Some difficulties were encountered by all investigators, while others affected only certain institutions, regions, or countries.

CONCLUSIONS: The results of the BIO-RAIDs programme highlight the need to facilitate and standardise regulatory procedures, and we feel that there is also a need for international working groups that make recommendations to regulatory bodies, governmental funding agencies, and academic institutions to achieve a proficient biobanking programme throughout EU countries. This represents the first step in precision medicine.

Original languageEnglish
Pages (from-to)1575-1583
Number of pages9
JournalBritish Journal of Cancer
Volume115
Issue number12
DOIs
Publication statusPublished - 6 Dec 2016

Cite this

Samuels, S., Balint, B., von der Leyen, H., Hupé, P., de Koning, L., Kamoun, C., ... Scholl, S. (2016). Precision medicine in cancer: challenges and recommendations from an EU-funded cervical cancer biobanking study. British Journal of Cancer, 115(12), 1575-1583. https://doi.org/10.1038/bjc.2016.340
Samuels, Sanne ; Balint, Balazs ; von der Leyen, Heiko ; Hupé, Philippe ; de Koning, Leanne ; Kamoun, Choumouss ; Luscap-Rondof, Windy ; Wittkop, Ulrike ; Bagrintseva, Ksenia ; Popovic, Marina ; Kereszt, Atttila ; Berns, Els ; Kenter, Gemma G ; Jordanova, Ekaterina S ; Kamal, Maud ; Scholl, Susy. / Precision medicine in cancer : challenges and recommendations from an EU-funded cervical cancer biobanking study. In: British Journal of Cancer. 2016 ; Vol. 115, No. 12. pp. 1575-1583.
@article{a719a8fb6bd646d392b67e4ac04d56ab,
title = "Precision medicine in cancer: challenges and recommendations from an EU-funded cervical cancer biobanking study",
abstract = "BACKGROUND: Cervical cancer (CC) remains a leading cause of gynaecological cancer-related mortality worldwide. CC pathogenesis is triggered when human papillomavirus (HPV) inserts into the genome, resulting in tumour suppressor gene inactivation and oncogene activation. Collecting tumour and blood samples is critical for identifying these genetic alterations.METHODS: BIO-RAIDs is the first prospective molecular profiling clinical study to include a substantial biobanking effort that used uniform high-quality standards and control of samples. In this European Union (EU)-funded study, we identified the challenges that were impeding the effective implementation of such a systematic and comprehensive biobanking effort.RESULTS: The challenges included a lack of uniform international legal and ethical standards, complexities in clinical and molecular data management, and difficulties in determining the best technical platforms and data analysis techniques. Some difficulties were encountered by all investigators, while others affected only certain institutions, regions, or countries.CONCLUSIONS: The results of the BIO-RAIDs programme highlight the need to facilitate and standardise regulatory procedures, and we feel that there is also a need for international working groups that make recommendations to regulatory bodies, governmental funding agencies, and academic institutions to achieve a proficient biobanking programme throughout EU countries. This represents the first step in precision medicine.",
author = "Sanne Samuels and Balazs Balint and {von der Leyen}, Heiko and Philippe Hup{\'e} and {de Koning}, Leanne and Choumouss Kamoun and Windy Luscap-Rondof and Ulrike Wittkop and Ksenia Bagrintseva and Marina Popovic and Atttila Kereszt and Els Berns and Kenter, {Gemma G} and Jordanova, {Ekaterina S} and Maud Kamal and Susy Scholl",
year = "2016",
month = "12",
day = "6",
doi = "10.1038/bjc.2016.340",
language = "English",
volume = "115",
pages = "1575--1583",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
number = "12",

}

Samuels, S, Balint, B, von der Leyen, H, Hupé, P, de Koning, L, Kamoun, C, Luscap-Rondof, W, Wittkop, U, Bagrintseva, K, Popovic, M, Kereszt, A, Berns, E, Kenter, GG, Jordanova, ES, Kamal, M & Scholl, S 2016, 'Precision medicine in cancer: challenges and recommendations from an EU-funded cervical cancer biobanking study' British Journal of Cancer, vol. 115, no. 12, pp. 1575-1583. https://doi.org/10.1038/bjc.2016.340

Precision medicine in cancer : challenges and recommendations from an EU-funded cervical cancer biobanking study. / Samuels, Sanne; Balint, Balazs; von der Leyen, Heiko; Hupé, Philippe; de Koning, Leanne; Kamoun, Choumouss; Luscap-Rondof, Windy; Wittkop, Ulrike; Bagrintseva, Ksenia; Popovic, Marina; Kereszt, Atttila; Berns, Els; Kenter, Gemma G; Jordanova, Ekaterina S; Kamal, Maud; Scholl, Susy.

In: British Journal of Cancer, Vol. 115, No. 12, 06.12.2016, p. 1575-1583.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Precision medicine in cancer

T2 - challenges and recommendations from an EU-funded cervical cancer biobanking study

AU - Samuels, Sanne

AU - Balint, Balazs

AU - von der Leyen, Heiko

AU - Hupé, Philippe

AU - de Koning, Leanne

AU - Kamoun, Choumouss

AU - Luscap-Rondof, Windy

AU - Wittkop, Ulrike

AU - Bagrintseva, Ksenia

AU - Popovic, Marina

AU - Kereszt, Atttila

AU - Berns, Els

AU - Kenter, Gemma G

AU - Jordanova, Ekaterina S

AU - Kamal, Maud

AU - Scholl, Susy

PY - 2016/12/6

Y1 - 2016/12/6

N2 - BACKGROUND: Cervical cancer (CC) remains a leading cause of gynaecological cancer-related mortality worldwide. CC pathogenesis is triggered when human papillomavirus (HPV) inserts into the genome, resulting in tumour suppressor gene inactivation and oncogene activation. Collecting tumour and blood samples is critical for identifying these genetic alterations.METHODS: BIO-RAIDs is the first prospective molecular profiling clinical study to include a substantial biobanking effort that used uniform high-quality standards and control of samples. In this European Union (EU)-funded study, we identified the challenges that were impeding the effective implementation of such a systematic and comprehensive biobanking effort.RESULTS: The challenges included a lack of uniform international legal and ethical standards, complexities in clinical and molecular data management, and difficulties in determining the best technical platforms and data analysis techniques. Some difficulties were encountered by all investigators, while others affected only certain institutions, regions, or countries.CONCLUSIONS: The results of the BIO-RAIDs programme highlight the need to facilitate and standardise regulatory procedures, and we feel that there is also a need for international working groups that make recommendations to regulatory bodies, governmental funding agencies, and academic institutions to achieve a proficient biobanking programme throughout EU countries. This represents the first step in precision medicine.

AB - BACKGROUND: Cervical cancer (CC) remains a leading cause of gynaecological cancer-related mortality worldwide. CC pathogenesis is triggered when human papillomavirus (HPV) inserts into the genome, resulting in tumour suppressor gene inactivation and oncogene activation. Collecting tumour and blood samples is critical for identifying these genetic alterations.METHODS: BIO-RAIDs is the first prospective molecular profiling clinical study to include a substantial biobanking effort that used uniform high-quality standards and control of samples. In this European Union (EU)-funded study, we identified the challenges that were impeding the effective implementation of such a systematic and comprehensive biobanking effort.RESULTS: The challenges included a lack of uniform international legal and ethical standards, complexities in clinical and molecular data management, and difficulties in determining the best technical platforms and data analysis techniques. Some difficulties were encountered by all investigators, while others affected only certain institutions, regions, or countries.CONCLUSIONS: The results of the BIO-RAIDs programme highlight the need to facilitate and standardise regulatory procedures, and we feel that there is also a need for international working groups that make recommendations to regulatory bodies, governmental funding agencies, and academic institutions to achieve a proficient biobanking programme throughout EU countries. This represents the first step in precision medicine.

U2 - 10.1038/bjc.2016.340

DO - 10.1038/bjc.2016.340

M3 - Article

VL - 115

SP - 1575

EP - 1583

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 12

ER -