@article{6bc70f5e32b6492ca4e5bf5c13e28764,
title = "Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria",
abstract = "During the past decade, a conceptual shift occurred in the field of Alzheimer's disease (AD) considering the disease as a continuum. Thanks to evolving biomarker research and substantial discoveries, it is now possible to identify the disease even at the preclinical stage before the occurrence of the first clinical symptoms. This preclinical stage of AD has become a major research focus as the field postulates that early intervention may offer the best chance of therapeutic success. To date, very little evidence is established on this “silent” stage of the disease. A clarification is needed about the definitions and lexicon, the limits, the natural history, the markers of progression, and the ethical consequence of detecting the disease at this asymptomatic stage. This article is aimed at addressing all the different issues by providing for each of them an updated review of the literature and evidence, with practical recommendations.",
keywords = "Alzheimer's disease, Preclinical, Asymptomatic, Diagnostic criteria, Biomarkers, Pathophysiology, Genetics, CSF biomarkers, Blood biomarkers, MRI, Amyloid PET, Tau PET",
author = "Bruno Dubois and Harald Hampel and Feldman, {Howard H.} and Philip Scheltens and Paul Aisen and Sandrine Andrieu and Hovagim Bakardjian and Habib Benali and Lars Bertram and Kaj Blennow and Karl Broich and Enrica Cavedo and Sebastian Crutch and Jean-Francois Dartigues and Charles Duyckaerts and Stephane Epelbaum and Frisoni, {Giovanni B.} and Serge Gauthier and Remy Genthon and Gouw, {Alida A.} and Marie-Odile Habert and Holtzman, {David M.} and Miia Kivipelto and Simone Lista and Jose-Luis Molinuevo and O'Bryant, {Sid E.} and Rabinovici, {Gil D.} and Christopher Rowe and Stephen Salloway and Schneider, {Lon S.} and Reisa Sperling and Marc Teichmann and Carrillo, {Maria C.} and Jeffrey Cummings and Jack, {Cliff R., Jr.}",
year = "2016",
month = mar,
doi = "10.1016/j.jalz.2016.02.002",
language = "English",
volume = "12",
pages = "292--323",
journal = "Alzheimers & Dementia",
issn = "1552-5260",
publisher = "Elsevier",
number = "3",
}