TY - JOUR
T1 - Preclinical Alzheimer's Disease: Implications for Refinement of the Concept
AU - Vos, Stephanie J. B.
AU - Visser, Pieter Jelle
PY - 2018
Y1 - 2018
N2 - Increasing interest in clinical trials and clinical research settings to identify Alzheimer's disease (AD) in the earliest stages of the disease has led to the concept of preclinical AD. Individuals with preclinical AD have AD pathology without clinical symptoms yet. Accumulating evidence has shown that biomarkers can identify preclinical AD and that preclinical AD is associated with a poor clinical outcome. Little is known yet about the role of vascular and lifestyle risk factors in the development of preclinical AD. In order to better understand preclinical AD pathology and clinical progression rates, there is a need to refine the concept of preclinical AD. This will be of great value for advancements in future research, clinical trials, and eventually clinical practice.
AB - Increasing interest in clinical trials and clinical research settings to identify Alzheimer's disease (AD) in the earliest stages of the disease has led to the concept of preclinical AD. Individuals with preclinical AD have AD pathology without clinical symptoms yet. Accumulating evidence has shown that biomarkers can identify preclinical AD and that preclinical AD is associated with a poor clinical outcome. Little is known yet about the role of vascular and lifestyle risk factors in the development of preclinical AD. In order to better understand preclinical AD pathology and clinical progression rates, there is a need to refine the concept of preclinical AD. This will be of great value for advancements in future research, clinical trials, and eventually clinical practice.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85048603224&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/29865060
U2 - 10.3233/JAD-179943
DO - 10.3233/JAD-179943
M3 - Review article
C2 - 29865060
VL - 64
SP - S213-S227
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
SN - 1387-2877
IS - s1
ER -