TY - JOUR
T1 - PREDICTIVE VALUE of OPTICAL COHERENCE TOMOGRAPHIC FEATURES in the BEVACIZUMAB and RANIBIZUMAB in PATIENTS with DIABETIC MACULAR EDEMA (BRDME) STUDY
AU - Fickweiler, Ward
AU - Schauwvlieghe, Ann-Sofie M. E.
AU - Schlingemann, Reinier O.
AU - Maria Hooymans, Johanna M.
AU - Los, Leonoor I.
AU - Verbraak, Frank D.
AU - BRDME RESEARCH GROUP
PY - 2018
Y1 - 2018
N2 - Purpose: To establish the predictive value of specific optical coherence tomography retinal features on visual outcomes and retinal thickness during anti-vascular endothelial growth factor treatment in patients with diabetic macular edema. Methods: Post hoc analysis of compound data of a prospective, 6-month, multicenter, randomized controlled trial of 119 patients with diabetic macular edema receiving either intravitreal bevacizumab or ranibizumab were analyzed to assess the associations between baseline retinal morphologic parameters and change in best-corrected visual acuity and central subfield thickness. Based on the study protocol of the core study, best-corrected visual acuity and central subfield thickness were obtained before each mandatory monthly injection during 6 months. Results: The presence of serous retinal detachment at baseline was associated with significant improvement in best-corrected visual acuity letter score at Month 3 and Month 6 (P < 0.001 and P = 0.01, respectively). In addition, the presence of disorganization of retinal inner layers was associated with lower best-corrected visual acuity letter score at Month 3 and Month 6 (P < 0.05 and P = 0.01, respectively). Conclusion: This study found that serous retinal detachment and disorganization of retinal inner layers were associated with different treatment responses to anti-vascular endothelial growth factor therapy in patients with diabetic macular edema.
AB - Purpose: To establish the predictive value of specific optical coherence tomography retinal features on visual outcomes and retinal thickness during anti-vascular endothelial growth factor treatment in patients with diabetic macular edema. Methods: Post hoc analysis of compound data of a prospective, 6-month, multicenter, randomized controlled trial of 119 patients with diabetic macular edema receiving either intravitreal bevacizumab or ranibizumab were analyzed to assess the associations between baseline retinal morphologic parameters and change in best-corrected visual acuity and central subfield thickness. Based on the study protocol of the core study, best-corrected visual acuity and central subfield thickness were obtained before each mandatory monthly injection during 6 months. Results: The presence of serous retinal detachment at baseline was associated with significant improvement in best-corrected visual acuity letter score at Month 3 and Month 6 (P < 0.001 and P = 0.01, respectively). In addition, the presence of disorganization of retinal inner layers was associated with lower best-corrected visual acuity letter score at Month 3 and Month 6 (P < 0.05 and P = 0.01, respectively). Conclusion: This study found that serous retinal detachment and disorganization of retinal inner layers were associated with different treatment responses to anti-vascular endothelial growth factor therapy in patients with diabetic macular edema.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85017416093&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/28406860
U2 - 10.1097/IAE.0000000000001626
DO - 10.1097/IAE.0000000000001626
M3 - Article
C2 - 28406860
VL - 38
SP - 812
EP - 819
JO - Retina-the journal of retinal and vitreous diseases
JF - Retina-the journal of retinal and vitreous diseases
SN - 0275-004X
IS - 4
ER -