Predictors of anxiety in early-stage Parkinson's disease: Results from the first two years of a prospective cohort study

S. Rutten, PM van de Ven, Daniel Weintraub, Gregory M. Pontone, Albert F. G. Leentjens, HW Berendse, YD van der Werf, OA van den Heuvel

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Aim Anxiety has a negative impact on daily functioning and quality of life in patients with Parkinson's disease (PD). This study aims at assessing which sociodemographic and clinical characteristics predict the course of anxiety in early PD. Methods The participants of this two-year prospective cohort study were recently diagnosed PD patients not receiving psychiatric medications or dopamine replacement therapy at baseline. Assessments were performed annually after baseline. The primary outcome measure was anxiety, as measured with the State-Trait Anxiety Inventory (STAI). Covariates were age, gender, family history, striatal dopamine transporter binding ratios, and severity of motor and non-motor features of PD at baseline. Data were analyzed using a mixed model analysis. Results Inclusion criteria were met by 306 subjects. An increase in STAI total score was predicted by older age, lower score on the Montreal Cognitive Assessment, and the presence of a probable REM-sleep behavior disorder (RBD) at baseline. A decrease in STAI total score over time was predicted by a higher baseline score on the 15-item Geriatric Depression Scale, compulsive behavior at baseline and a family history of PD. Conclusions More severe baseline anxiety was associated with compulsive behavior and depressive symptoms. These symptoms had a parallel course, showing a decrease over time. An increase in anxiety was predicted by older age, worse cognitive functioning and the presence of RBD. Our findings, when replicated in a sample of PD patients in a more advanced disease stage, could provide starting points for prevention of anxiety in PD patients.

Original languageEnglish
Pages (from-to)49-55
Number of pages7
JournalParkinsonism and Related Disorders
Volume43
DOIs
Publication statusPublished - 1 Oct 2017

Cite this

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title = "Predictors of anxiety in early-stage Parkinson's disease: Results from the first two years of a prospective cohort study",
abstract = "Aim Anxiety has a negative impact on daily functioning and quality of life in patients with Parkinson's disease (PD). This study aims at assessing which sociodemographic and clinical characteristics predict the course of anxiety in early PD. Methods The participants of this two-year prospective cohort study were recently diagnosed PD patients not receiving psychiatric medications or dopamine replacement therapy at baseline. Assessments were performed annually after baseline. The primary outcome measure was anxiety, as measured with the State-Trait Anxiety Inventory (STAI). Covariates were age, gender, family history, striatal dopamine transporter binding ratios, and severity of motor and non-motor features of PD at baseline. Data were analyzed using a mixed model analysis. Results Inclusion criteria were met by 306 subjects. An increase in STAI total score was predicted by older age, lower score on the Montreal Cognitive Assessment, and the presence of a probable REM-sleep behavior disorder (RBD) at baseline. A decrease in STAI total score over time was predicted by a higher baseline score on the 15-item Geriatric Depression Scale, compulsive behavior at baseline and a family history of PD. Conclusions More severe baseline anxiety was associated with compulsive behavior and depressive symptoms. These symptoms had a parallel course, showing a decrease over time. An increase in anxiety was predicted by older age, worse cognitive functioning and the presence of RBD. Our findings, when replicated in a sample of PD patients in a more advanced disease stage, could provide starting points for prevention of anxiety in PD patients.",
keywords = "Anxiety, Longitudinal, Neuropsychiatry, Parkinson's disease, Risk factor",
author = "S. Rutten and {van de Ven}, PM and Daniel Weintraub and Pontone, {Gregory M.} and Leentjens, {Albert F. G.} and HW Berendse and {van der Werf}, YD and {van den Heuvel}, OA",
year = "2017",
month = "10",
day = "1",
doi = "10.1016/j.parkreldis.2017.06.024",
language = "English",
volume = "43",
pages = "49--55",
journal = "Parkinsonism and Related Disorders",
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Predictors of anxiety in early-stage Parkinson's disease : Results from the first two years of a prospective cohort study. / Rutten, S.; van de Ven, PM; Weintraub, Daniel; Pontone, Gregory M.; Leentjens, Albert F. G.; Berendse, HW; van der Werf, YD; van den Heuvel, OA.

In: Parkinsonism and Related Disorders, Vol. 43, 01.10.2017, p. 49-55.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Predictors of anxiety in early-stage Parkinson's disease

T2 - Results from the first two years of a prospective cohort study

AU - Rutten, S.

AU - van de Ven, PM

AU - Weintraub, Daniel

AU - Pontone, Gregory M.

AU - Leentjens, Albert F. G.

AU - Berendse, HW

AU - van der Werf, YD

AU - van den Heuvel, OA

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Aim Anxiety has a negative impact on daily functioning and quality of life in patients with Parkinson's disease (PD). This study aims at assessing which sociodemographic and clinical characteristics predict the course of anxiety in early PD. Methods The participants of this two-year prospective cohort study were recently diagnosed PD patients not receiving psychiatric medications or dopamine replacement therapy at baseline. Assessments were performed annually after baseline. The primary outcome measure was anxiety, as measured with the State-Trait Anxiety Inventory (STAI). Covariates were age, gender, family history, striatal dopamine transporter binding ratios, and severity of motor and non-motor features of PD at baseline. Data were analyzed using a mixed model analysis. Results Inclusion criteria were met by 306 subjects. An increase in STAI total score was predicted by older age, lower score on the Montreal Cognitive Assessment, and the presence of a probable REM-sleep behavior disorder (RBD) at baseline. A decrease in STAI total score over time was predicted by a higher baseline score on the 15-item Geriatric Depression Scale, compulsive behavior at baseline and a family history of PD. Conclusions More severe baseline anxiety was associated with compulsive behavior and depressive symptoms. These symptoms had a parallel course, showing a decrease over time. An increase in anxiety was predicted by older age, worse cognitive functioning and the presence of RBD. Our findings, when replicated in a sample of PD patients in a more advanced disease stage, could provide starting points for prevention of anxiety in PD patients.

AB - Aim Anxiety has a negative impact on daily functioning and quality of life in patients with Parkinson's disease (PD). This study aims at assessing which sociodemographic and clinical characteristics predict the course of anxiety in early PD. Methods The participants of this two-year prospective cohort study were recently diagnosed PD patients not receiving psychiatric medications or dopamine replacement therapy at baseline. Assessments were performed annually after baseline. The primary outcome measure was anxiety, as measured with the State-Trait Anxiety Inventory (STAI). Covariates were age, gender, family history, striatal dopamine transporter binding ratios, and severity of motor and non-motor features of PD at baseline. Data were analyzed using a mixed model analysis. Results Inclusion criteria were met by 306 subjects. An increase in STAI total score was predicted by older age, lower score on the Montreal Cognitive Assessment, and the presence of a probable REM-sleep behavior disorder (RBD) at baseline. A decrease in STAI total score over time was predicted by a higher baseline score on the 15-item Geriatric Depression Scale, compulsive behavior at baseline and a family history of PD. Conclusions More severe baseline anxiety was associated with compulsive behavior and depressive symptoms. These symptoms had a parallel course, showing a decrease over time. An increase in anxiety was predicted by older age, worse cognitive functioning and the presence of RBD. Our findings, when replicated in a sample of PD patients in a more advanced disease stage, could provide starting points for prevention of anxiety in PD patients.

KW - Anxiety

KW - Longitudinal

KW - Neuropsychiatry

KW - Parkinson's disease

KW - Risk factor

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U2 - 10.1016/j.parkreldis.2017.06.024

DO - 10.1016/j.parkreldis.2017.06.024

M3 - Article

VL - 43

SP - 49

EP - 55

JO - Parkinsonism and Related Disorders

JF - Parkinsonism and Related Disorders

SN - 1353-8020

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