Prefrontal Cortical Projection Neurons Targeting Dorsomedial Striatum Control Behavioral Inhibition

Huub Terra, Bastiaan Bruinsma, Sybren F. de Kloet, Marcel van der Roest, Tommy Pattij, Huibert D. Mansvelder*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

A neural pathway from prefrontal cortex (PFC) to dorsal striatum (DS) has been suggested to mediate cognitive control of behavior, including proactive inhibitory control and attention. However, a direct causal demonstration thereof is lacking. Here, we show that selective chemogenetic silencing of corticostriatal PFC neurons in rats increases premature responses. Wireless single-unit electrophysiological recordings of optogenetically identified corticostriatal PFC neurons revealed that the majority of these neurons encode behavioral trial outcome with persistent changes in firing rate. Attentional parameters were not affected by silencing corticostriatal PFC neurons, suggesting that these projection neurons encode a specific subset of cognitive behaviors. Compared to the general non-identified neuronal population in the PFC, frontostriatal neurons showed selective engagement during periods of inhibitory control. Our results demonstrate a role for corticostriatal neurons in inhibitory control and possibly suggest that distinct domains of cognitive control over behavior are encoded by specific projection neuron populations.
Original languageEnglish
JournalCurrent Biology
DOIs
Publication statusE-pub ahead of print - 2020

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