Abstract

BACKGROUND: Preoperative interpretation of resectability of diffuse nonenhancing glioma is primarily based on individual surgical expertise. OBJECTIVE: To compare the accuracy and precision between observed resections and preoperative estimates of neurosurgeons and a resection probability map (RPM). We hypothesize that the RPM estimates is as good as senior neurosurgeons. METHODS: A total of 234 consecutive patients were included from 2 centers, who had resective surgery with functional mapping between 2006 and 2012 for a supra-tentorial nonenhancing glioma. Extent of resection (EOR) and residual tumor volume (RTV) were segmented and an RPM was constructed in standard brain space. Three junior and three senior neurosurgeons estimated EOR and RTV, blinded for postoperative results. We determined the agreement between the estimates and calculated the diagnostic accuracy of the neurosurgeons and the RPM to predict the observed resections. RESULTS: Preoperative estimates of resection results by junior and senior neurosurgeons were significantly biased towards overestimation of EOR (4.2% and 11.2%) and underestimation of RTV (4.3 and 9.0 mL), whereas estimates of the RPM were unbiased (-2.6% and -.2 mL, respectively). The limits of agreement were wide for neurosurgeons and for the RPM. The RPM was significantly more accurate in identifying patients in whom an EOR >40% was observed than neurosurgeons. CONCLUSION: Neurosurgeons estimate preoperative resectability before surgery of a nonenhancing glioma rather accurate-with a small bias-and imprecise-with wide limits of agreement. An RPM provides unbiased resectability estimates, which can be useful for surgical decision-making, planning, and education.

Original languageEnglish
Pages (from-to)E304-E313
JournalNeurosurgery
Volume85
Issue number2
DOIs
Publication statusPublished - 1 Aug 2019

Cite this

Hendriks, Eef J. ; Idema, Sander ; Hervey-Jumper, Shawn L. ; Bernat, Anne Laure ; Zwinderman, Aeilko H. ; Barkhof, Frederik ; Vandertop, W. Peter ; Mandonnet, Emmanuel ; Duffau, Hugues ; Berger, Mitchel S. ; De Witt Hamer, Philip C. / Preoperative Resectability Estimates of Nonenhancing Glioma by Neurosurgeons and a Resection Probability Map. In: Neurosurgery. 2019 ; Vol. 85, No. 2. pp. E304-E313.
@article{331154a6ffcc44cdb3e537640c35344e,
title = "Preoperative Resectability Estimates of Nonenhancing Glioma by Neurosurgeons and a Resection Probability Map",
abstract = "BACKGROUND: Preoperative interpretation of resectability of diffuse nonenhancing glioma is primarily based on individual surgical expertise. OBJECTIVE: To compare the accuracy and precision between observed resections and preoperative estimates of neurosurgeons and a resection probability map (RPM). We hypothesize that the RPM estimates is as good as senior neurosurgeons. METHODS: A total of 234 consecutive patients were included from 2 centers, who had resective surgery with functional mapping between 2006 and 2012 for a supra-tentorial nonenhancing glioma. Extent of resection (EOR) and residual tumor volume (RTV) were segmented and an RPM was constructed in standard brain space. Three junior and three senior neurosurgeons estimated EOR and RTV, blinded for postoperative results. We determined the agreement between the estimates and calculated the diagnostic accuracy of the neurosurgeons and the RPM to predict the observed resections. RESULTS: Preoperative estimates of resection results by junior and senior neurosurgeons were significantly biased towards overestimation of EOR (4.2{\%} and 11.2{\%}) and underestimation of RTV (4.3 and 9.0 mL), whereas estimates of the RPM were unbiased (-2.6{\%} and -.2 mL, respectively). The limits of agreement were wide for neurosurgeons and for the RPM. The RPM was significantly more accurate in identifying patients in whom an EOR >40{\%} was observed than neurosurgeons. CONCLUSION: Neurosurgeons estimate preoperative resectability before surgery of a nonenhancing glioma rather accurate-with a small bias-and imprecise-with wide limits of agreement. An RPM provides unbiased resectability estimates, which can be useful for surgical decision-making, planning, and education.",
keywords = "Extent of resection, Glioma, Neurosurgery, Resection probability map, Residual tumor volume",
author = "Hendriks, {Eef J.} and Sander Idema and Hervey-Jumper, {Shawn L.} and Bernat, {Anne Laure} and Zwinderman, {Aeilko H.} and Frederik Barkhof and Vandertop, {W. Peter} and Emmanuel Mandonnet and Hugues Duffau and Berger, {Mitchel S.} and {De Witt Hamer}, {Philip C.}",
year = "2019",
month = "8",
day = "1",
doi = "10.1093/neuros/nyy487",
language = "English",
volume = "85",
pages = "E304--E313",
journal = "Neurosurgery",
issn = "0148-396X",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

Preoperative Resectability Estimates of Nonenhancing Glioma by Neurosurgeons and a Resection Probability Map. / Hendriks, Eef J.; Idema, Sander; Hervey-Jumper, Shawn L.; Bernat, Anne Laure; Zwinderman, Aeilko H.; Barkhof, Frederik; Vandertop, W. Peter; Mandonnet, Emmanuel; Duffau, Hugues; Berger, Mitchel S.; De Witt Hamer, Philip C.

In: Neurosurgery, Vol. 85, No. 2, 01.08.2019, p. E304-E313.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Preoperative Resectability Estimates of Nonenhancing Glioma by Neurosurgeons and a Resection Probability Map

AU - Hendriks, Eef J.

AU - Idema, Sander

AU - Hervey-Jumper, Shawn L.

AU - Bernat, Anne Laure

AU - Zwinderman, Aeilko H.

AU - Barkhof, Frederik

AU - Vandertop, W. Peter

AU - Mandonnet, Emmanuel

AU - Duffau, Hugues

AU - Berger, Mitchel S.

AU - De Witt Hamer, Philip C.

PY - 2019/8/1

Y1 - 2019/8/1

N2 - BACKGROUND: Preoperative interpretation of resectability of diffuse nonenhancing glioma is primarily based on individual surgical expertise. OBJECTIVE: To compare the accuracy and precision between observed resections and preoperative estimates of neurosurgeons and a resection probability map (RPM). We hypothesize that the RPM estimates is as good as senior neurosurgeons. METHODS: A total of 234 consecutive patients were included from 2 centers, who had resective surgery with functional mapping between 2006 and 2012 for a supra-tentorial nonenhancing glioma. Extent of resection (EOR) and residual tumor volume (RTV) were segmented and an RPM was constructed in standard brain space. Three junior and three senior neurosurgeons estimated EOR and RTV, blinded for postoperative results. We determined the agreement between the estimates and calculated the diagnostic accuracy of the neurosurgeons and the RPM to predict the observed resections. RESULTS: Preoperative estimates of resection results by junior and senior neurosurgeons were significantly biased towards overestimation of EOR (4.2% and 11.2%) and underestimation of RTV (4.3 and 9.0 mL), whereas estimates of the RPM were unbiased (-2.6% and -.2 mL, respectively). The limits of agreement were wide for neurosurgeons and for the RPM. The RPM was significantly more accurate in identifying patients in whom an EOR >40% was observed than neurosurgeons. CONCLUSION: Neurosurgeons estimate preoperative resectability before surgery of a nonenhancing glioma rather accurate-with a small bias-and imprecise-with wide limits of agreement. An RPM provides unbiased resectability estimates, which can be useful for surgical decision-making, planning, and education.

AB - BACKGROUND: Preoperative interpretation of resectability of diffuse nonenhancing glioma is primarily based on individual surgical expertise. OBJECTIVE: To compare the accuracy and precision between observed resections and preoperative estimates of neurosurgeons and a resection probability map (RPM). We hypothesize that the RPM estimates is as good as senior neurosurgeons. METHODS: A total of 234 consecutive patients were included from 2 centers, who had resective surgery with functional mapping between 2006 and 2012 for a supra-tentorial nonenhancing glioma. Extent of resection (EOR) and residual tumor volume (RTV) were segmented and an RPM was constructed in standard brain space. Three junior and three senior neurosurgeons estimated EOR and RTV, blinded for postoperative results. We determined the agreement between the estimates and calculated the diagnostic accuracy of the neurosurgeons and the RPM to predict the observed resections. RESULTS: Preoperative estimates of resection results by junior and senior neurosurgeons were significantly biased towards overestimation of EOR (4.2% and 11.2%) and underestimation of RTV (4.3 and 9.0 mL), whereas estimates of the RPM were unbiased (-2.6% and -.2 mL, respectively). The limits of agreement were wide for neurosurgeons and for the RPM. The RPM was significantly more accurate in identifying patients in whom an EOR >40% was observed than neurosurgeons. CONCLUSION: Neurosurgeons estimate preoperative resectability before surgery of a nonenhancing glioma rather accurate-with a small bias-and imprecise-with wide limits of agreement. An RPM provides unbiased resectability estimates, which can be useful for surgical decision-making, planning, and education.

KW - Extent of resection

KW - Glioma

KW - Neurosurgery

KW - Resection probability map

KW - Residual tumor volume

UR - http://www.scopus.com/inward/record.url?scp=85062744267&partnerID=8YFLogxK

U2 - 10.1093/neuros/nyy487

DO - 10.1093/neuros/nyy487

M3 - Article

VL - 85

SP - E304-E313

JO - Neurosurgery

JF - Neurosurgery

SN - 0148-396X

IS - 2

ER -