Prevalence and Risk Factors of Early Endocrine Disorders in Childhood Brain Tumor Survivors: A Nationwide, Multicenter Study

Sarah C Clement, Antoinette Y N Schouten-van Meeteren, Annemieke M Boot, Hedy L Claahsen-van der Grinten, Bernd Granzen, K Sen Han, Geert O Janssens, Erna M Michiels, A S Paul van Trotsenburg, W Peter Vandertop, Dannis G van Vuurden, Leontien C M Kremer, Hubert N Caron, Hanneke M van Santen

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Purpose To evaluate the prevalence of, and risk factors for, early endocrine disorders in childhood brain tumor survivors (CBTS). Patients and Methods This nationwide study cohort consisted of 718 CBTS who were diagnosed between 2002 and 2012, and who survived ≥ 2 years after diagnosis. Patients with craniopharyngeoma or a pituitary gland tumor were excluded. Results of all endocrine investigations, which were performed at diagnosis and during follow-up, were collected from patient charts. Multivariable logistic regression was used to study associations between demographic and tumor- and treatment-related variables and the prevalence of early endocrine disorders. Results After a median follow-up of 6.6 years, 178 CBTS (24.8%) were diagnosed with an endocrine disorder. A total of 159 CBTS (22.1%) presented with at least one endocrine disorder within the first 5 years after diagnosis. The most common endocrine disorders were growth hormone deficiency (12.5%), precocious puberty (12.2%), thyroid-stimulating hormone deficiency (9.2%), and thyroidal hypothyroidism (5.8%). The risk of hypothalamic-pituitary dysfunction (n = 138) was associated with radiotherapy (odds ratio [OR], 15.74; 95% CI, 8.72 to 28.42), younger age at diagnosis (OR, 1.09; 95% CI, 1.04 to 1.14), advanced follow-up time (OR, 1.10; 95% CI, 1.02 to 1.18), hydrocephalus at diagnosis (OR, 1.77; 95% CI, 1.09 to 2.88), and suprasellar (OR, 34.18; 95% CI, 14.74 to 79.29) and infratentorial (OR, 2.65; 95% CI, 1.48 to 4.74) tumor site. Conclusion The prevalence of early endocrine disorders among CBTS is high. The observation that 22.1% of CBTS developed at least one endocrine disorder within the first 5 years after diagnosis stresses the importance of early and regular assessment of endocrine function in CBTS who are at risk for endocrine damage.

Original languageEnglish
Pages (from-to)4362-4370
Number of pages9
JournalJournal of Clinical Oncology
Volume34
Issue number36
Publication statusPublished - 20 Dec 2016

Cite this

Clement, S. C., Schouten-van Meeteren, A. Y. N., Boot, A. M., Claahsen-van der Grinten, H. L., Granzen, B., Sen Han, K., ... van Santen, H. M. (2016). Prevalence and Risk Factors of Early Endocrine Disorders in Childhood Brain Tumor Survivors: A Nationwide, Multicenter Study. Journal of Clinical Oncology, 34(36), 4362-4370.
Clement, Sarah C ; Schouten-van Meeteren, Antoinette Y N ; Boot, Annemieke M ; Claahsen-van der Grinten, Hedy L ; Granzen, Bernd ; Sen Han, K ; Janssens, Geert O ; Michiels, Erna M ; van Trotsenburg, A S Paul ; Vandertop, W Peter ; van Vuurden, Dannis G ; Kremer, Leontien C M ; Caron, Hubert N ; van Santen, Hanneke M. / Prevalence and Risk Factors of Early Endocrine Disorders in Childhood Brain Tumor Survivors : A Nationwide, Multicenter Study. In: Journal of Clinical Oncology. 2016 ; Vol. 34, No. 36. pp. 4362-4370.
@article{ad5afb27c9f84a80b0c6df77a4888f31,
title = "Prevalence and Risk Factors of Early Endocrine Disorders in Childhood Brain Tumor Survivors: A Nationwide, Multicenter Study",
abstract = "Purpose To evaluate the prevalence of, and risk factors for, early endocrine disorders in childhood brain tumor survivors (CBTS). Patients and Methods This nationwide study cohort consisted of 718 CBTS who were diagnosed between 2002 and 2012, and who survived ≥ 2 years after diagnosis. Patients with craniopharyngeoma or a pituitary gland tumor were excluded. Results of all endocrine investigations, which were performed at diagnosis and during follow-up, were collected from patient charts. Multivariable logistic regression was used to study associations between demographic and tumor- and treatment-related variables and the prevalence of early endocrine disorders. Results After a median follow-up of 6.6 years, 178 CBTS (24.8{\%}) were diagnosed with an endocrine disorder. A total of 159 CBTS (22.1{\%}) presented with at least one endocrine disorder within the first 5 years after diagnosis. The most common endocrine disorders were growth hormone deficiency (12.5{\%}), precocious puberty (12.2{\%}), thyroid-stimulating hormone deficiency (9.2{\%}), and thyroidal hypothyroidism (5.8{\%}). The risk of hypothalamic-pituitary dysfunction (n = 138) was associated with radiotherapy (odds ratio [OR], 15.74; 95{\%} CI, 8.72 to 28.42), younger age at diagnosis (OR, 1.09; 95{\%} CI, 1.04 to 1.14), advanced follow-up time (OR, 1.10; 95{\%} CI, 1.02 to 1.18), hydrocephalus at diagnosis (OR, 1.77; 95{\%} CI, 1.09 to 2.88), and suprasellar (OR, 34.18; 95{\%} CI, 14.74 to 79.29) and infratentorial (OR, 2.65; 95{\%} CI, 1.48 to 4.74) tumor site. Conclusion The prevalence of early endocrine disorders among CBTS is high. The observation that 22.1{\%} of CBTS developed at least one endocrine disorder within the first 5 years after diagnosis stresses the importance of early and regular assessment of endocrine function in CBTS who are at risk for endocrine damage.",
author = "Clement, {Sarah C} and {Schouten-van Meeteren}, {Antoinette Y N} and Boot, {Annemieke M} and {Claahsen-van der Grinten}, {Hedy L} and Bernd Granzen and {Sen Han}, K and Janssens, {Geert O} and Michiels, {Erna M} and {van Trotsenburg}, {A S Paul} and Vandertop, {W Peter} and {van Vuurden}, {Dannis G} and Kremer, {Leontien C M} and Caron, {Hubert N} and {van Santen}, {Hanneke M}",
year = "2016",
month = "12",
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language = "English",
volume = "34",
pages = "4362--4370",
journal = "Journal of Clinical Oncology",
issn = "0732-183X",
publisher = "American Society of Clinical Oncology",
number = "36",

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Clement, SC, Schouten-van Meeteren, AYN, Boot, AM, Claahsen-van der Grinten, HL, Granzen, B, Sen Han, K, Janssens, GO, Michiels, EM, van Trotsenburg, ASP, Vandertop, WP, van Vuurden, DG, Kremer, LCM, Caron, HN & van Santen, HM 2016, 'Prevalence and Risk Factors of Early Endocrine Disorders in Childhood Brain Tumor Survivors: A Nationwide, Multicenter Study' Journal of Clinical Oncology, vol. 34, no. 36, pp. 4362-4370.

Prevalence and Risk Factors of Early Endocrine Disorders in Childhood Brain Tumor Survivors : A Nationwide, Multicenter Study. / Clement, Sarah C; Schouten-van Meeteren, Antoinette Y N; Boot, Annemieke M; Claahsen-van der Grinten, Hedy L; Granzen, Bernd; Sen Han, K; Janssens, Geert O; Michiels, Erna M; van Trotsenburg, A S Paul; Vandertop, W Peter; van Vuurden, Dannis G; Kremer, Leontien C M; Caron, Hubert N; van Santen, Hanneke M.

In: Journal of Clinical Oncology, Vol. 34, No. 36, 20.12.2016, p. 4362-4370.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Prevalence and Risk Factors of Early Endocrine Disorders in Childhood Brain Tumor Survivors

T2 - A Nationwide, Multicenter Study

AU - Clement, Sarah C

AU - Schouten-van Meeteren, Antoinette Y N

AU - Boot, Annemieke M

AU - Claahsen-van der Grinten, Hedy L

AU - Granzen, Bernd

AU - Sen Han, K

AU - Janssens, Geert O

AU - Michiels, Erna M

AU - van Trotsenburg, A S Paul

AU - Vandertop, W Peter

AU - van Vuurden, Dannis G

AU - Kremer, Leontien C M

AU - Caron, Hubert N

AU - van Santen, Hanneke M

PY - 2016/12/20

Y1 - 2016/12/20

N2 - Purpose To evaluate the prevalence of, and risk factors for, early endocrine disorders in childhood brain tumor survivors (CBTS). Patients and Methods This nationwide study cohort consisted of 718 CBTS who were diagnosed between 2002 and 2012, and who survived ≥ 2 years after diagnosis. Patients with craniopharyngeoma or a pituitary gland tumor were excluded. Results of all endocrine investigations, which were performed at diagnosis and during follow-up, were collected from patient charts. Multivariable logistic regression was used to study associations between demographic and tumor- and treatment-related variables and the prevalence of early endocrine disorders. Results After a median follow-up of 6.6 years, 178 CBTS (24.8%) were diagnosed with an endocrine disorder. A total of 159 CBTS (22.1%) presented with at least one endocrine disorder within the first 5 years after diagnosis. The most common endocrine disorders were growth hormone deficiency (12.5%), precocious puberty (12.2%), thyroid-stimulating hormone deficiency (9.2%), and thyroidal hypothyroidism (5.8%). The risk of hypothalamic-pituitary dysfunction (n = 138) was associated with radiotherapy (odds ratio [OR], 15.74; 95% CI, 8.72 to 28.42), younger age at diagnosis (OR, 1.09; 95% CI, 1.04 to 1.14), advanced follow-up time (OR, 1.10; 95% CI, 1.02 to 1.18), hydrocephalus at diagnosis (OR, 1.77; 95% CI, 1.09 to 2.88), and suprasellar (OR, 34.18; 95% CI, 14.74 to 79.29) and infratentorial (OR, 2.65; 95% CI, 1.48 to 4.74) tumor site. Conclusion The prevalence of early endocrine disorders among CBTS is high. The observation that 22.1% of CBTS developed at least one endocrine disorder within the first 5 years after diagnosis stresses the importance of early and regular assessment of endocrine function in CBTS who are at risk for endocrine damage.

AB - Purpose To evaluate the prevalence of, and risk factors for, early endocrine disorders in childhood brain tumor survivors (CBTS). Patients and Methods This nationwide study cohort consisted of 718 CBTS who were diagnosed between 2002 and 2012, and who survived ≥ 2 years after diagnosis. Patients with craniopharyngeoma or a pituitary gland tumor were excluded. Results of all endocrine investigations, which were performed at diagnosis and during follow-up, were collected from patient charts. Multivariable logistic regression was used to study associations between demographic and tumor- and treatment-related variables and the prevalence of early endocrine disorders. Results After a median follow-up of 6.6 years, 178 CBTS (24.8%) were diagnosed with an endocrine disorder. A total of 159 CBTS (22.1%) presented with at least one endocrine disorder within the first 5 years after diagnosis. The most common endocrine disorders were growth hormone deficiency (12.5%), precocious puberty (12.2%), thyroid-stimulating hormone deficiency (9.2%), and thyroidal hypothyroidism (5.8%). The risk of hypothalamic-pituitary dysfunction (n = 138) was associated with radiotherapy (odds ratio [OR], 15.74; 95% CI, 8.72 to 28.42), younger age at diagnosis (OR, 1.09; 95% CI, 1.04 to 1.14), advanced follow-up time (OR, 1.10; 95% CI, 1.02 to 1.18), hydrocephalus at diagnosis (OR, 1.77; 95% CI, 1.09 to 2.88), and suprasellar (OR, 34.18; 95% CI, 14.74 to 79.29) and infratentorial (OR, 2.65; 95% CI, 1.48 to 4.74) tumor site. Conclusion The prevalence of early endocrine disorders among CBTS is high. The observation that 22.1% of CBTS developed at least one endocrine disorder within the first 5 years after diagnosis stresses the importance of early and regular assessment of endocrine function in CBTS who are at risk for endocrine damage.

M3 - Article

VL - 34

SP - 4362

EP - 4370

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

SN - 0732-183X

IS - 36

ER -

Clement SC, Schouten-van Meeteren AYN, Boot AM, Claahsen-van der Grinten HL, Granzen B, Sen Han K et al. Prevalence and Risk Factors of Early Endocrine Disorders in Childhood Brain Tumor Survivors: A Nationwide, Multicenter Study. Journal of Clinical Oncology. 2016 Dec 20;34(36):4362-4370.