Prevalence of Gastroesophageal Reflux Disease Symptoms in Infants and Children: A Systematic Review

Maartje Singendonk, Eline Goudswaard, Miranda Langendam, Michiel van Wijk, Faridi van Etten-Jamaludin, Marc Benninga, Merit Tabbers

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

OBJECTIVES: Gastroesophageal reflux disease (GERD) is defined as GER causing troublesome symptoms or complications. In this study we reviewed the literature regarding the prevalence of GERD symptoms in infants and children.

METHODS: Databases of PubMed, EMBASE and Cochrane were systematically searched from inception to June 26, 2018. English-written studies based on birth cohort, school based or general population samples of ≥50 children aged 0-21 years were included. Convenience samples were excluded.

RESULTS: In total, 3581 unique studies were found, of which 25 studies (11 in infants and 14 in children) were included with data on the prevalence of GERD symptoms comprising a total population of 487969 children. In infants (0-18 months), GERD symptoms 1) are present in more than a quarter of infants on a daily basis and 2) show a steady decline in frequency with almost complete disappearance of symptoms at the age of 12 months. In children >18 months, GERD symptoms show large variation in prevalence between studies (range 0%-38% of study population) and overall, are present in more than 10% and in 25% on respectively a weekly and monthly basis. Of the risk factors assessed, higher BMI and the use of alcohol and tobacco were associated with higher GERD symptom prevalence.

CONCLUSIONS: This systematic review demonstrates that the reported prevalence of GERD symptoms varies considerably, depending on method of data collection and criteria used to define symptoms. Nevertheless, the high reported prevalence rates support better investment of resources and educational campaigns focused on prevention.

LanguageEnglish
JournalJournal of Pediatric Gastroenterology and Nutrition
DOIs
Publication statusE-pub ahead of print - 21 Jan 2019

Cite this

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title = "Prevalence of Gastroesophageal Reflux Disease Symptoms in Infants and Children: A Systematic Review",
abstract = "OBJECTIVES: Gastroesophageal reflux disease (GERD) is defined as GER causing troublesome symptoms or complications. In this study we reviewed the literature regarding the prevalence of GERD symptoms in infants and children.METHODS: Databases of PubMed, EMBASE and Cochrane were systematically searched from inception to June 26, 2018. English-written studies based on birth cohort, school based or general population samples of ≥50 children aged 0-21 years were included. Convenience samples were excluded.RESULTS: In total, 3581 unique studies were found, of which 25 studies (11 in infants and 14 in children) were included with data on the prevalence of GERD symptoms comprising a total population of 487969 children. In infants (0-18 months), GERD symptoms 1) are present in more than a quarter of infants on a daily basis and 2) show a steady decline in frequency with almost complete disappearance of symptoms at the age of 12 months. In children >18 months, GERD symptoms show large variation in prevalence between studies (range 0{\%}-38{\%} of study population) and overall, are present in more than 10{\%} and in 25{\%} on respectively a weekly and monthly basis. Of the risk factors assessed, higher BMI and the use of alcohol and tobacco were associated with higher GERD symptom prevalence.CONCLUSIONS: This systematic review demonstrates that the reported prevalence of GERD symptoms varies considerably, depending on method of data collection and criteria used to define symptoms. Nevertheless, the high reported prevalence rates support better investment of resources and educational campaigns focused on prevention.",
author = "Maartje Singendonk and Eline Goudswaard and Miranda Langendam and {van Wijk}, Michiel and {van Etten-Jamaludin}, Faridi and Marc Benninga and Merit Tabbers",
year = "2019",
month = "1",
day = "21",
doi = "10.1097/MPG.0000000000002280",
language = "English",
journal = "Journal of Pediatric Gastroenterology and Nutrition",
issn = "0277-2116",
publisher = "Lippincott Williams and Wilkins",

}

Prevalence of Gastroesophageal Reflux Disease Symptoms in Infants and Children : A Systematic Review. / Singendonk, Maartje; Goudswaard, Eline; Langendam, Miranda; van Wijk, Michiel; van Etten-Jamaludin, Faridi; Benninga, Marc; Tabbers, Merit.

In: Journal of Pediatric Gastroenterology and Nutrition, 21.01.2019.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Prevalence of Gastroesophageal Reflux Disease Symptoms in Infants and Children

T2 - Journal of Pediatric Gastroenterology and Nutrition

AU - Singendonk, Maartje

AU - Goudswaard, Eline

AU - Langendam, Miranda

AU - van Wijk, Michiel

AU - van Etten-Jamaludin, Faridi

AU - Benninga, Marc

AU - Tabbers, Merit

PY - 2019/1/21

Y1 - 2019/1/21

N2 - OBJECTIVES: Gastroesophageal reflux disease (GERD) is defined as GER causing troublesome symptoms or complications. In this study we reviewed the literature regarding the prevalence of GERD symptoms in infants and children.METHODS: Databases of PubMed, EMBASE and Cochrane were systematically searched from inception to June 26, 2018. English-written studies based on birth cohort, school based or general population samples of ≥50 children aged 0-21 years were included. Convenience samples were excluded.RESULTS: In total, 3581 unique studies were found, of which 25 studies (11 in infants and 14 in children) were included with data on the prevalence of GERD symptoms comprising a total population of 487969 children. In infants (0-18 months), GERD symptoms 1) are present in more than a quarter of infants on a daily basis and 2) show a steady decline in frequency with almost complete disappearance of symptoms at the age of 12 months. In children >18 months, GERD symptoms show large variation in prevalence between studies (range 0%-38% of study population) and overall, are present in more than 10% and in 25% on respectively a weekly and monthly basis. Of the risk factors assessed, higher BMI and the use of alcohol and tobacco were associated with higher GERD symptom prevalence.CONCLUSIONS: This systematic review demonstrates that the reported prevalence of GERD symptoms varies considerably, depending on method of data collection and criteria used to define symptoms. Nevertheless, the high reported prevalence rates support better investment of resources and educational campaigns focused on prevention.

AB - OBJECTIVES: Gastroesophageal reflux disease (GERD) is defined as GER causing troublesome symptoms or complications. In this study we reviewed the literature regarding the prevalence of GERD symptoms in infants and children.METHODS: Databases of PubMed, EMBASE and Cochrane were systematically searched from inception to June 26, 2018. English-written studies based on birth cohort, school based or general population samples of ≥50 children aged 0-21 years were included. Convenience samples were excluded.RESULTS: In total, 3581 unique studies were found, of which 25 studies (11 in infants and 14 in children) were included with data on the prevalence of GERD symptoms comprising a total population of 487969 children. In infants (0-18 months), GERD symptoms 1) are present in more than a quarter of infants on a daily basis and 2) show a steady decline in frequency with almost complete disappearance of symptoms at the age of 12 months. In children >18 months, GERD symptoms show large variation in prevalence between studies (range 0%-38% of study population) and overall, are present in more than 10% and in 25% on respectively a weekly and monthly basis. Of the risk factors assessed, higher BMI and the use of alcohol and tobacco were associated with higher GERD symptom prevalence.CONCLUSIONS: This systematic review demonstrates that the reported prevalence of GERD symptoms varies considerably, depending on method of data collection and criteria used to define symptoms. Nevertheless, the high reported prevalence rates support better investment of resources and educational campaigns focused on prevention.

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JO - Journal of Pediatric Gastroenterology and Nutrition

JF - Journal of Pediatric Gastroenterology and Nutrition

SN - 0277-2116

ER -