Prevalence of malnutrition and validation of bioelectrical impedance analysis for the assessment of body composition in patients with systemic sclerosis

Moon J. Spanjer, Irene E.M. Bultink, Marian A.E. de van der Schueren, Alexandre E. Voskuy

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objectives. The aims were to assess the prevalence of malnutrition and to validate bioelectrical impedance analysis (BIA) against whole-body DXA for the assessment of body composition in patients with SSc. Methods. Malnutrition was defined as BMI<18.5 kg/m2 or unintentional weight loss>10% in combination with a fat-free mass index (FFMI)<15 kg/m2 for women or<17 kg/m2 for men or BMI<20.0 kg/m2 (age<70 years) or<22 kg/m2 (age>70 years). Body composition was assessed in 72 patients with whole-body DXA (Hologic, Discovery A) and BIA (Bodystat Quadscan 400). The manufacturer's equation and the Geneva equation were used to estimate FFM and fat mass. The agreement between BIA and whole-body DXA was assessed with Bland-Altman analysis and intraclass correlation coefficient. Results. Malnutrition was found in 8.3% (n = 6) and low FFMI in 20.8% (n = 15) of patients. The mean difference in FFM between BIA and DXA applying the Geneva equation was 0.02 (S.D. 2.4) kg, intraclass correlation coefficient 0.97 (95% CI: 0.95, 0.98). Limits of agreement were ±4.6 kg. The manufacturer's equation was less adequate to predict FFM. Conclusion. This study shows a relatively low prevalence of malnutrition in comparison with other studies, but a high prevalence of low FFMI, underlining the necessity of measuring body composition in SSc patients with a standardized and validated method. A good validity of BIA in determining FFM was found at a group level, while at an individual level the FFM may vary by 4.6 kg.

Original languageEnglish
Article numberkex014
Pages (from-to)1008-1012
Number of pages5
JournalRheumatology (United Kingdom)
Volume56
Issue number6
DOIs
Publication statusPublished - 1 Jun 2017

Cite this

@article{d51cb19cf0264833b6a67ff62d9bc41d,
title = "Prevalence of malnutrition and validation of bioelectrical impedance analysis for the assessment of body composition in patients with systemic sclerosis",
abstract = "Objectives. The aims were to assess the prevalence of malnutrition and to validate bioelectrical impedance analysis (BIA) against whole-body DXA for the assessment of body composition in patients with SSc. Methods. Malnutrition was defined as BMI<18.5 kg/m2 or unintentional weight loss>10{\%} in combination with a fat-free mass index (FFMI)<15 kg/m2 for women or<17 kg/m2 for men or BMI<20.0 kg/m2 (age<70 years) or<22 kg/m2 (age>70 years). Body composition was assessed in 72 patients with whole-body DXA (Hologic, Discovery A) and BIA (Bodystat Quadscan 400). The manufacturer's equation and the Geneva equation were used to estimate FFM and fat mass. The agreement between BIA and whole-body DXA was assessed with Bland-Altman analysis and intraclass correlation coefficient. Results. Malnutrition was found in 8.3{\%} (n = 6) and low FFMI in 20.8{\%} (n = 15) of patients. The mean difference in FFM between BIA and DXA applying the Geneva equation was 0.02 (S.D. 2.4) kg, intraclass correlation coefficient 0.97 (95{\%} CI: 0.95, 0.98). Limits of agreement were ±4.6 kg. The manufacturer's equation was less adequate to predict FFM. Conclusion. This study shows a relatively low prevalence of malnutrition in comparison with other studies, but a high prevalence of low FFMI, underlining the necessity of measuring body composition in SSc patients with a standardized and validated method. A good validity of BIA in determining FFM was found at a group level, while at an individual level the FFM may vary by 4.6 kg.",
keywords = "Bioelectrical impedance analysis, Body composition, Dual-energy X-ray absorptiometry, Malnutrition, Systemic sclerosis",
author = "Spanjer, {Moon J.} and Bultink, {Irene E.M.} and {de van der Schueren}, {Marian A.E.} and Voskuy, {Alexandre E.}",
year = "2017",
month = "6",
day = "1",
doi = "10.1093/rheumatology/kex014",
language = "English",
volume = "56",
pages = "1008--1012",
journal = "Rheumatology",
issn = "1462-0324",
publisher = "Oxford University Press",
number = "6",

}

Prevalence of malnutrition and validation of bioelectrical impedance analysis for the assessment of body composition in patients with systemic sclerosis. / Spanjer, Moon J.; Bultink, Irene E.M.; de van der Schueren, Marian A.E.; Voskuy, Alexandre E.

In: Rheumatology (United Kingdom), Vol. 56, No. 6, kex014, 01.06.2017, p. 1008-1012.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Prevalence of malnutrition and validation of bioelectrical impedance analysis for the assessment of body composition in patients with systemic sclerosis

AU - Spanjer, Moon J.

AU - Bultink, Irene E.M.

AU - de van der Schueren, Marian A.E.

AU - Voskuy, Alexandre E.

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Objectives. The aims were to assess the prevalence of malnutrition and to validate bioelectrical impedance analysis (BIA) against whole-body DXA for the assessment of body composition in patients with SSc. Methods. Malnutrition was defined as BMI<18.5 kg/m2 or unintentional weight loss>10% in combination with a fat-free mass index (FFMI)<15 kg/m2 for women or<17 kg/m2 for men or BMI<20.0 kg/m2 (age<70 years) or<22 kg/m2 (age>70 years). Body composition was assessed in 72 patients with whole-body DXA (Hologic, Discovery A) and BIA (Bodystat Quadscan 400). The manufacturer's equation and the Geneva equation were used to estimate FFM and fat mass. The agreement between BIA and whole-body DXA was assessed with Bland-Altman analysis and intraclass correlation coefficient. Results. Malnutrition was found in 8.3% (n = 6) and low FFMI in 20.8% (n = 15) of patients. The mean difference in FFM between BIA and DXA applying the Geneva equation was 0.02 (S.D. 2.4) kg, intraclass correlation coefficient 0.97 (95% CI: 0.95, 0.98). Limits of agreement were ±4.6 kg. The manufacturer's equation was less adequate to predict FFM. Conclusion. This study shows a relatively low prevalence of malnutrition in comparison with other studies, but a high prevalence of low FFMI, underlining the necessity of measuring body composition in SSc patients with a standardized and validated method. A good validity of BIA in determining FFM was found at a group level, while at an individual level the FFM may vary by 4.6 kg.

AB - Objectives. The aims were to assess the prevalence of malnutrition and to validate bioelectrical impedance analysis (BIA) against whole-body DXA for the assessment of body composition in patients with SSc. Methods. Malnutrition was defined as BMI<18.5 kg/m2 or unintentional weight loss>10% in combination with a fat-free mass index (FFMI)<15 kg/m2 for women or<17 kg/m2 for men or BMI<20.0 kg/m2 (age<70 years) or<22 kg/m2 (age>70 years). Body composition was assessed in 72 patients with whole-body DXA (Hologic, Discovery A) and BIA (Bodystat Quadscan 400). The manufacturer's equation and the Geneva equation were used to estimate FFM and fat mass. The agreement between BIA and whole-body DXA was assessed with Bland-Altman analysis and intraclass correlation coefficient. Results. Malnutrition was found in 8.3% (n = 6) and low FFMI in 20.8% (n = 15) of patients. The mean difference in FFM between BIA and DXA applying the Geneva equation was 0.02 (S.D. 2.4) kg, intraclass correlation coefficient 0.97 (95% CI: 0.95, 0.98). Limits of agreement were ±4.6 kg. The manufacturer's equation was less adequate to predict FFM. Conclusion. This study shows a relatively low prevalence of malnutrition in comparison with other studies, but a high prevalence of low FFMI, underlining the necessity of measuring body composition in SSc patients with a standardized and validated method. A good validity of BIA in determining FFM was found at a group level, while at an individual level the FFM may vary by 4.6 kg.

KW - Bioelectrical impedance analysis

KW - Body composition

KW - Dual-energy X-ray absorptiometry

KW - Malnutrition

KW - Systemic sclerosis

UR - http://www.scopus.com/inward/record.url?scp=85021111442&partnerID=8YFLogxK

U2 - 10.1093/rheumatology/kex014

DO - 10.1093/rheumatology/kex014

M3 - Article

VL - 56

SP - 1008

EP - 1012

JO - Rheumatology

JF - Rheumatology

SN - 1462-0324

IS - 6

M1 - kex014

ER -