@article{b1d25109c8ea47859571ebe86b739d87,
title = "Prevalence of radiologically isolated syndrome in a pediatric population-based cohort: A longitudinal description of a rare diagnosis",
abstract = "Background: Radiologically isolated syndrome (RIS) is typified by multiple sclerosis (MS)-like lesions on imaging, without clinical MS symptoms. The prevalence of pediatric RIS is largely unknown. Objective: The objective of the study is to provide an estimated RIS prevalence in a population-based cohort of children. Methods: We used data from the Generation R study to identify the childhood RIS prevalence. Results: In 5238 participants, only one RIS case was identified (prevalence: 0.02%; 95% confidence interval (CI): 0.00–0.11). During a 62-month follow-up, imaging examinations showed accrual of new focal demyelinating lesions; however, no clinical MS symptoms occurred. Conclusions: This study shows that the occurrence of RIS in children from the general population is rare.",
keywords = "case reports, epidemiology, multiple sclerosis, pediatrics, prevalence, Radiologically isolated syndrome",
author = "{de Mol}, {C. L.} and Bruijstens, {A. L.} and Jansen, {P. R.} and Dremmen, {M. H.G.} and Wong, {Y. Y.M.} and {van der Lugt}, A. and White, {T. J.H.} and Neuteboom, {R. F.}",
note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was supported by the Dutch MS Research Foundation. The general design of the Generation R Study is supported by the Erasmus Medical Center, the Erasmus University Rotterdam, the ZonMw, the NOW, and the Ministry of Health, Welfare, and Sport. Publisher Copyright: {\textcopyright} The Author(s), 2021. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
doi = "10.1177/1352458521989220",
language = "English",
journal = "Multiple Sclerosis",
issn = "1352-4585",
publisher = "SAGE Publications Ltd",
}