Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort

Min Kim, Stuart Snowden, Tommi Suvitaival, Ashfaq Ali, David J. Merkler, Tahmina Ahmad, Sarah Westwood, Alison Baird, Petroula Proitsi, Alejo Nevado-Holgado, Abdul Hye, Isabelle Bos, Stephanie Vos, Rik Vandenberghe, Charlotte Teunissen, Mara ten Kate, Philip Scheltens, Silvy Gabel, Karen Meersmans, Olivier Blin & 31 others Jill Richardson, Ellen de Roeck, Kristel Sleegers, R. gis Bordet, Lorena Rami, Petronella Kettunen, Magda Tsolaki, Frans Verhey, Isabel Sala, Alberto Lléo, Gwendoline Peyratout, Mikel Tainta, Peter Johannsen, Yvonne Freund-Levi, Lutz Frölich, Valerija Dobricic, Sebastiaan Engelborghs, Giovanni B. Frisoni, José L. Molinuevo, Anders Wallin, Julius Popp, Pablo Martinez-Lage, Lars Bertram, Frederik Barkhof, Nicholas Ashton, Kaj Blennow, Henrik Zetterberg, Johannes Streffer, Pieter J. Visser, Simon Lovestone, Cristina Legido-Quigley

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Introduction: A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers. Methods: This study analyzed 593 plasma samples selected from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery study, of individuals who were cognitively healthy (n = 242), had mild cognitive impairment (n = 236), or had AD-type dementia (n = 115). Logistic regressions were carried out between plasma metabolites (n = 883) and CSF markers, magnetic resonance imaging, cognition, and clinical diagnosis. Results: Eight metabolites were associated with amyloid β and one with t-tau in CSF, these were primary fatty acid amides (PFAMs), lipokines, and amino acids. From these, PFAMs, glutamate, and aspartate also associated with hippocampal volume and memory. Discussion: PFAMs have been found increased and associated with amyloid β burden in CSF and clinical measures.
Original languageEnglish
Pages (from-to)817-827
JournalAlzheimer's and Dementia
Volume15
Issue number6
DOIs
Publication statusPublished - 2019

Cite this

Kim, Min ; Snowden, Stuart ; Suvitaival, Tommi ; Ali, Ashfaq ; Merkler, David J. ; Ahmad, Tahmina ; Westwood, Sarah ; Baird, Alison ; Proitsi, Petroula ; Nevado-Holgado, Alejo ; Hye, Abdul ; Bos, Isabelle ; Vos, Stephanie ; Vandenberghe, Rik ; Teunissen, Charlotte ; ten Kate, Mara ; Scheltens, Philip ; Gabel, Silvy ; Meersmans, Karen ; Blin, Olivier ; Richardson, Jill ; de Roeck, Ellen ; Sleegers, Kristel ; Bordet, R. gis ; Rami, Lorena ; Kettunen, Petronella ; Tsolaki, Magda ; Verhey, Frans ; Sala, Isabel ; Lléo, Alberto ; Peyratout, Gwendoline ; Tainta, Mikel ; Johannsen, Peter ; Freund-Levi, Yvonne ; Frölich, Lutz ; Dobricic, Valerija ; Engelborghs, Sebastiaan ; Frisoni, Giovanni B. ; Molinuevo, José L. ; Wallin, Anders ; Popp, Julius ; Martinez-Lage, Pablo ; Bertram, Lars ; Barkhof, Frederik ; Ashton, Nicholas ; Blennow, Kaj ; Zetterberg, Henrik ; Streffer, Johannes ; Visser, Pieter J. ; Lovestone, Simon ; Legido-Quigley, Cristina. / Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort. In: Alzheimer's and Dementia. 2019 ; Vol. 15, No. 6. pp. 817-827.
@article{8f7831616be04a6b83bb0acc76e5de63,
title = "Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort",
abstract = "Introduction: A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers. Methods: This study analyzed 593 plasma samples selected from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery study, of individuals who were cognitively healthy (n = 242), had mild cognitive impairment (n = 236), or had AD-type dementia (n = 115). Logistic regressions were carried out between plasma metabolites (n = 883) and CSF markers, magnetic resonance imaging, cognition, and clinical diagnosis. Results: Eight metabolites were associated with amyloid β and one with t-tau in CSF, these were primary fatty acid amides (PFAMs), lipokines, and amino acids. From these, PFAMs, glutamate, and aspartate also associated with hippocampal volume and memory. Discussion: PFAMs have been found increased and associated with amyloid β burden in CSF and clinical measures.",
author = "Min Kim and Stuart Snowden and Tommi Suvitaival and Ashfaq Ali and Merkler, {David J.} and Tahmina Ahmad and Sarah Westwood and Alison Baird and Petroula Proitsi and Alejo Nevado-Holgado and Abdul Hye and Isabelle Bos and Stephanie Vos and Rik Vandenberghe and Charlotte Teunissen and {ten Kate}, Mara and Philip Scheltens and Silvy Gabel and Karen Meersmans and Olivier Blin and Jill Richardson and {de Roeck}, Ellen and Kristel Sleegers and Bordet, {R. gis} and Lorena Rami and Petronella Kettunen and Magda Tsolaki and Frans Verhey and Isabel Sala and Alberto Ll{\'e}o and Gwendoline Peyratout and Mikel Tainta and Peter Johannsen and Yvonne Freund-Levi and Lutz Fr{\"o}lich and Valerija Dobricic and Sebastiaan Engelborghs and Frisoni, {Giovanni B.} and Molinuevo, {Jos{\'e} L.} and Anders Wallin and Julius Popp and Pablo Martinez-Lage and Lars Bertram and Frederik Barkhof and Nicholas Ashton and Kaj Blennow and Henrik Zetterberg and Johannes Streffer and Visser, {Pieter J.} and Simon Lovestone and Cristina Legido-Quigley",
year = "2019",
doi = "10.1016/j.jalz.2019.03.004",
language = "English",
volume = "15",
pages = "817--827",
journal = "Alzheimers & Dementia",
issn = "1552-5260",
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Kim, M, Snowden, S, Suvitaival, T, Ali, A, Merkler, DJ, Ahmad, T, Westwood, S, Baird, A, Proitsi, P, Nevado-Holgado, A, Hye, A, Bos, I, Vos, S, Vandenberghe, R, Teunissen, C, ten Kate, M, Scheltens, P, Gabel, S, Meersmans, K, Blin, O, Richardson, J, de Roeck, E, Sleegers, K, Bordet, RG, Rami, L, Kettunen, P, Tsolaki, M, Verhey, F, Sala, I, Lléo, A, Peyratout, G, Tainta, M, Johannsen, P, Freund-Levi, Y, Frölich, L, Dobricic, V, Engelborghs, S, Frisoni, GB, Molinuevo, JL, Wallin, A, Popp, J, Martinez-Lage, P, Bertram, L, Barkhof, F, Ashton, N, Blennow, K, Zetterberg, H, Streffer, J, Visser, PJ, Lovestone, S & Legido-Quigley, C 2019, 'Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort' Alzheimer's and Dementia, vol. 15, no. 6, pp. 817-827. https://doi.org/10.1016/j.jalz.2019.03.004

Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort. / Kim, Min; Snowden, Stuart; Suvitaival, Tommi; Ali, Ashfaq; Merkler, David J.; Ahmad, Tahmina; Westwood, Sarah; Baird, Alison; Proitsi, Petroula; Nevado-Holgado, Alejo; Hye, Abdul; Bos, Isabelle; Vos, Stephanie; Vandenberghe, Rik; Teunissen, Charlotte; ten Kate, Mara; Scheltens, Philip; Gabel, Silvy; Meersmans, Karen; Blin, Olivier; Richardson, Jill; de Roeck, Ellen; Sleegers, Kristel; Bordet, R. gis; Rami, Lorena; Kettunen, Petronella; Tsolaki, Magda; Verhey, Frans; Sala, Isabel; Lléo, Alberto; Peyratout, Gwendoline; Tainta, Mikel; Johannsen, Peter; Freund-Levi, Yvonne; Frölich, Lutz; Dobricic, Valerija; Engelborghs, Sebastiaan; Frisoni, Giovanni B.; Molinuevo, José L.; Wallin, Anders; Popp, Julius; Martinez-Lage, Pablo; Bertram, Lars; Barkhof, Frederik; Ashton, Nicholas; Blennow, Kaj; Zetterberg, Henrik; Streffer, Johannes; Visser, Pieter J.; Lovestone, Simon; Legido-Quigley, Cristina.

In: Alzheimer's and Dementia, Vol. 15, No. 6, 2019, p. 817-827.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Primary fatty amides in plasma associated with brain amyloid burden, hippocampal volume, and memory in the European Medical Information Framework for Alzheimer's Disease biomarker discovery cohort

AU - Kim, Min

AU - Snowden, Stuart

AU - Suvitaival, Tommi

AU - Ali, Ashfaq

AU - Merkler, David J.

AU - Ahmad, Tahmina

AU - Westwood, Sarah

AU - Baird, Alison

AU - Proitsi, Petroula

AU - Nevado-Holgado, Alejo

AU - Hye, Abdul

AU - Bos, Isabelle

AU - Vos, Stephanie

AU - Vandenberghe, Rik

AU - Teunissen, Charlotte

AU - ten Kate, Mara

AU - Scheltens, Philip

AU - Gabel, Silvy

AU - Meersmans, Karen

AU - Blin, Olivier

AU - Richardson, Jill

AU - de Roeck, Ellen

AU - Sleegers, Kristel

AU - Bordet, R. gis

AU - Rami, Lorena

AU - Kettunen, Petronella

AU - Tsolaki, Magda

AU - Verhey, Frans

AU - Sala, Isabel

AU - Lléo, Alberto

AU - Peyratout, Gwendoline

AU - Tainta, Mikel

AU - Johannsen, Peter

AU - Freund-Levi, Yvonne

AU - Frölich, Lutz

AU - Dobricic, Valerija

AU - Engelborghs, Sebastiaan

AU - Frisoni, Giovanni B.

AU - Molinuevo, José L.

AU - Wallin, Anders

AU - Popp, Julius

AU - Martinez-Lage, Pablo

AU - Bertram, Lars

AU - Barkhof, Frederik

AU - Ashton, Nicholas

AU - Blennow, Kaj

AU - Zetterberg, Henrik

AU - Streffer, Johannes

AU - Visser, Pieter J.

AU - Lovestone, Simon

AU - Legido-Quigley, Cristina

PY - 2019

Y1 - 2019

N2 - Introduction: A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers. Methods: This study analyzed 593 plasma samples selected from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery study, of individuals who were cognitively healthy (n = 242), had mild cognitive impairment (n = 236), or had AD-type dementia (n = 115). Logistic regressions were carried out between plasma metabolites (n = 883) and CSF markers, magnetic resonance imaging, cognition, and clinical diagnosis. Results: Eight metabolites were associated with amyloid β and one with t-tau in CSF, these were primary fatty acid amides (PFAMs), lipokines, and amino acids. From these, PFAMs, glutamate, and aspartate also associated with hippocampal volume and memory. Discussion: PFAMs have been found increased and associated with amyloid β burden in CSF and clinical measures.

AB - Introduction: A critical and as-yet unmet need in Alzheimer's disease (AD) is the discovery of peripheral small molecule biomarkers. Given that brain pathology precedes clinical symptom onset, we set out to test whether metabolites in blood associated with pathology as indexed by cerebrospinal fluid (CSF) AD biomarkers. Methods: This study analyzed 593 plasma samples selected from the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery study, of individuals who were cognitively healthy (n = 242), had mild cognitive impairment (n = 236), or had AD-type dementia (n = 115). Logistic regressions were carried out between plasma metabolites (n = 883) and CSF markers, magnetic resonance imaging, cognition, and clinical diagnosis. Results: Eight metabolites were associated with amyloid β and one with t-tau in CSF, these were primary fatty acid amides (PFAMs), lipokines, and amino acids. From these, PFAMs, glutamate, and aspartate also associated with hippocampal volume and memory. Discussion: PFAMs have been found increased and associated with amyloid β burden in CSF and clinical measures.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/31078433

U2 - 10.1016/j.jalz.2019.03.004

DO - 10.1016/j.jalz.2019.03.004

M3 - Article

VL - 15

SP - 817

EP - 827

JO - Alzheimers & Dementia

JF - Alzheimers & Dementia

SN - 1552-5260

IS - 6

ER -