Priming of 6-hydroxydopamine-lesioned rats with L-DOPA or quinpirole results in an increase in dopamine D1 receptor-dependent cyclic AMP production in striatal tissue

A Pinna, M Morelli, B Drukarch, J C Stoof

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Priming with a dopamine agonist greatly enhances the behavioral effectiveness of dopamine D1 receptor agonists in rats with 6-hydroxydopamine lesions of the nigrostriatal pathway. The present study investigated the influence of priming on cyclic AMP production in striatal slices. Stimulation of dopamine D1 receptors with dopamine or the dopamine D1 receptor agonist, 1-phenyl-6-Cl-7,8-diol-2,3,4,5-tetrahydro-(1H)-3-benzazepine (SKF 81297), increased cyclic AMP production in the lesioned striatum of rats primed with L-3,4-dihydroxyphenylalanine (L-DOPA) by 329% and 405%, respectively, whereas in drug-naive rats the increase was 183% and 187%, respectively. Priming with quinpirole produced similar results. It is suggested that priming with either L-DOPA or a dopamine D2 receptor agonist results in increased effectiveness of dopamine D1 signal transduction, apparently not only related to previous stimulation of D1 receptors.

Original languageEnglish
Pages (from-to)23-6
Number of pages4
JournalEuropean Journal of Pharmacology
Volume331
Issue number1
Publication statusPublished - 16 Jul 1997

Cite this

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title = "Priming of 6-hydroxydopamine-lesioned rats with L-DOPA or quinpirole results in an increase in dopamine D1 receptor-dependent cyclic AMP production in striatal tissue",
abstract = "Priming with a dopamine agonist greatly enhances the behavioral effectiveness of dopamine D1 receptor agonists in rats with 6-hydroxydopamine lesions of the nigrostriatal pathway. The present study investigated the influence of priming on cyclic AMP production in striatal slices. Stimulation of dopamine D1 receptors with dopamine or the dopamine D1 receptor agonist, 1-phenyl-6-Cl-7,8-diol-2,3,4,5-tetrahydro-(1H)-3-benzazepine (SKF 81297), increased cyclic AMP production in the lesioned striatum of rats primed with L-3,4-dihydroxyphenylalanine (L-DOPA) by 329{\%} and 405{\%}, respectively, whereas in drug-naive rats the increase was 183{\%} and 187{\%}, respectively. Priming with quinpirole produced similar results. It is suggested that priming with either L-DOPA or a dopamine D2 receptor agonist results in increased effectiveness of dopamine D1 signal transduction, apparently not only related to previous stimulation of D1 receptors.",
keywords = "Animals, Benzazepines, Corpus Striatum, Cyclic AMP, Dopamine, Dopamine Agonists, In Vitro Techniques, Levodopa, Male, Oxidopamine, Quinpirole, Rats, Rats, Wistar, Receptors, Dopamine D1, Journal Article, Research Support, Non-U.S. Gov't",
author = "A Pinna and M Morelli and B Drukarch and Stoof, {J C}",
year = "1997",
month = "7",
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language = "English",
volume = "331",
pages = "23--6",
journal = "European Journal of Pharmacology",
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Priming of 6-hydroxydopamine-lesioned rats with L-DOPA or quinpirole results in an increase in dopamine D1 receptor-dependent cyclic AMP production in striatal tissue. / Pinna, A; Morelli, M; Drukarch, B; Stoof, J C.

In: European Journal of Pharmacology, Vol. 331, No. 1, 16.07.1997, p. 23-6.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Priming of 6-hydroxydopamine-lesioned rats with L-DOPA or quinpirole results in an increase in dopamine D1 receptor-dependent cyclic AMP production in striatal tissue

AU - Pinna, A

AU - Morelli, M

AU - Drukarch, B

AU - Stoof, J C

PY - 1997/7/16

Y1 - 1997/7/16

N2 - Priming with a dopamine agonist greatly enhances the behavioral effectiveness of dopamine D1 receptor agonists in rats with 6-hydroxydopamine lesions of the nigrostriatal pathway. The present study investigated the influence of priming on cyclic AMP production in striatal slices. Stimulation of dopamine D1 receptors with dopamine or the dopamine D1 receptor agonist, 1-phenyl-6-Cl-7,8-diol-2,3,4,5-tetrahydro-(1H)-3-benzazepine (SKF 81297), increased cyclic AMP production in the lesioned striatum of rats primed with L-3,4-dihydroxyphenylalanine (L-DOPA) by 329% and 405%, respectively, whereas in drug-naive rats the increase was 183% and 187%, respectively. Priming with quinpirole produced similar results. It is suggested that priming with either L-DOPA or a dopamine D2 receptor agonist results in increased effectiveness of dopamine D1 signal transduction, apparently not only related to previous stimulation of D1 receptors.

AB - Priming with a dopamine agonist greatly enhances the behavioral effectiveness of dopamine D1 receptor agonists in rats with 6-hydroxydopamine lesions of the nigrostriatal pathway. The present study investigated the influence of priming on cyclic AMP production in striatal slices. Stimulation of dopamine D1 receptors with dopamine or the dopamine D1 receptor agonist, 1-phenyl-6-Cl-7,8-diol-2,3,4,5-tetrahydro-(1H)-3-benzazepine (SKF 81297), increased cyclic AMP production in the lesioned striatum of rats primed with L-3,4-dihydroxyphenylalanine (L-DOPA) by 329% and 405%, respectively, whereas in drug-naive rats the increase was 183% and 187%, respectively. Priming with quinpirole produced similar results. It is suggested that priming with either L-DOPA or a dopamine D2 receptor agonist results in increased effectiveness of dopamine D1 signal transduction, apparently not only related to previous stimulation of D1 receptors.

KW - Animals

KW - Benzazepines

KW - Corpus Striatum

KW - Cyclic AMP

KW - Dopamine

KW - Dopamine Agonists

KW - In Vitro Techniques

KW - Levodopa

KW - Male

KW - Oxidopamine

KW - Quinpirole

KW - Rats

KW - Rats, Wistar

KW - Receptors, Dopamine D1

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - Article

VL - 331

SP - 23

EP - 26

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 1

ER -