Abstract
In unilaterally 6-hydroxydopamine-lesioned rats, potentiation of D1-agonist-induced turning behavior by priming with l-DOPA was correlated with changes in striatal neuropeptide mRNA levels. In non-primed rats, administration of the D1-agonist SKF-38393 markedly increased dynorphin and substance P mRNA levels in the lesioned striatum. Priming with l-DOPA dissociated the response of the two neuropeptides to the D1-agonist, with higher dynorphin and reduced substance P mRNA levels.
| Original language | English |
|---|---|
| Pages (from-to) | 219-23 |
| Number of pages | 5 |
| Journal | Experimental Brain Research |
| Volume | 61 |
| Issue number | 1-2 |
| Publication status | Published - 30 Oct 1998 |
Cite this
van de Witte, S. V., Drukarch, B., Stoof, J. C., & Voorn, P. (1998). Priming with L-DOPA differently affects dynorphin and substance P mRNA levels in the striatum of 6-hydroxydopamine-lesioned rats after challenge with dopamine D1-receptor agonist. Experimental Brain Research, 61(1-2), 219-23.