@article{b4f64c0db1bb45cdadc64838f1353fb3,
title = "Priming with L-DOPA differently affects dynorphin and substance P mRNA levels in the striatum of 6-hydroxydopamine-lesioned rats after challenge with dopamine D1-receptor agonist",
abstract = "In unilaterally 6-hydroxydopamine-lesioned rats, potentiation of D1-agonist-induced turning behavior by priming with l-DOPA was correlated with changes in striatal neuropeptide mRNA levels. In non-primed rats, administration of the D1-agonist SKF-38393 markedly increased dynorphin and substance P mRNA levels in the lesioned striatum. Priming with l-DOPA dissociated the response of the two neuropeptides to the D1-agonist, with higher dynorphin and reduced substance P mRNA levels.",
keywords = "2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, Animals, Brain, Corpus Striatum, Dynorphins, Injections, Intraperitoneal, Injections, Subcutaneous, Levodopa, Male, Oxidopamine, RNA, Messenger, Rats, Rats, Wistar, Receptors, Dopamine D1, Stereotaxic Techniques, Substance P, Journal Article, Research Support, Non-U.S. Gov't",
author = "{van de Witte}, {S V} and B Drukarch and Stoof, {J C} and P Voorn",
note = "Copyright 1998 Elsevier Science B.V.",
year = "1998",
month = oct,
day = "30",
language = "English",
volume = "61",
pages = "219--23",
journal = "Experimental Brain Research",
issn = "0014-4819",
publisher = "Springer Verlag",
number = "1-2",
}