Objective: This article describes the process evaluation of the Depression in Elderly with Long-Term Afflictions (DELTA) intervention, a nurse-led minimal psychological intervention to reduce depression in chronically ill elderly persons. The aim was to assess whether the DELTA intervention was implemented and received as planned, which barriers were encountered and whether nurses and patients were satisfied with the intervention. Methods: Quantitative and qualitative data were gathered from all 183 patients who participated in the intervention and from four nurses who administered the intervention. Data were assessed by means of self-administered questionnaires, checklists, and a group interview with the nurses. Results: Although several barriers were encountered, the intervention was well performed by nurses and well received by patients. However, a small proportion of the patients found the intervention not useful and thought they would not benefit. Conclusion: The implementation of the minimal psychological intervention aimed at reducing depression in chronically ill elderly persons was successful and therefore feasible. Practice implications: By making the intervention part of regular care for patients with a chronic condition, patients can be monitored and, if necessary, support can be provided to implement the intervention in their daily life.