Production of a monoclonal antibody (K 931) to a squamous cell carcinoma associated antigen identified as the 17-1A antigen

J. J. Quak, G. Van Dongen, J. G.P. Brakkee, D. J. Hayashida, A. J.M. Balm, G. B. Snow, C. J.L.M. Meijer

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

During our efforts to develop monoclonal antibodies (MAbs) to tumor associated surface antigens of squamous cell carcinomas of the head and neck, monoclonal antibody K 931 was produced. The high affinity antibody (K(a) 5.0 x 1010 M-1) showed reactivity with 58 out of 62 squamous carcinomas of the head and neck. In contrast normal squamous epithelium as found in epidermis, oral cavity, epiglottis, pharynx, larynx and esophagus did not express the antigen. All other tested epithelial (simple and transitional) tissues did express the antigen, but non-epithelial tissues were negative. Further characterization revealed that the antigen represents the 17-1A antigen. A not earlier reported, enhanced expression of the 17-1A antigen was observed among some primary and all metastatic SCC.

Original languageEnglish
Pages (from-to)377-387
Number of pages11
JournalHybridoma
Volume9
Issue number4
DOIs
Publication statusPublished - 1 Jan 1990

Cite this

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title = "Production of a monoclonal antibody (K 931) to a squamous cell carcinoma associated antigen identified as the 17-1A antigen",
abstract = "During our efforts to develop monoclonal antibodies (MAbs) to tumor associated surface antigens of squamous cell carcinomas of the head and neck, monoclonal antibody K 931 was produced. The high affinity antibody (K(a) 5.0 x 1010 M-1) showed reactivity with 58 out of 62 squamous carcinomas of the head and neck. In contrast normal squamous epithelium as found in epidermis, oral cavity, epiglottis, pharynx, larynx and esophagus did not express the antigen. All other tested epithelial (simple and transitional) tissues did express the antigen, but non-epithelial tissues were negative. Further characterization revealed that the antigen represents the 17-1A antigen. A not earlier reported, enhanced expression of the 17-1A antigen was observed among some primary and all metastatic SCC.",
author = "Quak, {J. J.} and {Van Dongen}, G. and Brakkee, {J. G.P.} and Hayashida, {D. J.} and Balm, {A. J.M.} and Snow, {G. B.} and Meijer, {C. J.L.M.}",
year = "1990",
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day = "1",
doi = "10.1089/hyb.1990.9.377",
language = "English",
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pages = "377--387",
journal = "Hybridoma",
issn = "0272-457X",
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Production of a monoclonal antibody (K 931) to a squamous cell carcinoma associated antigen identified as the 17-1A antigen. / Quak, J. J.; Van Dongen, G.; Brakkee, J. G.P.; Hayashida, D. J.; Balm, A. J.M.; Snow, G. B.; Meijer, C. J.L.M.

In: Hybridoma, Vol. 9, No. 4, 01.01.1990, p. 377-387.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Production of a monoclonal antibody (K 931) to a squamous cell carcinoma associated antigen identified as the 17-1A antigen

AU - Quak, J. J.

AU - Van Dongen, G.

AU - Brakkee, J. G.P.

AU - Hayashida, D. J.

AU - Balm, A. J.M.

AU - Snow, G. B.

AU - Meijer, C. J.L.M.

PY - 1990/1/1

Y1 - 1990/1/1

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AB - During our efforts to develop monoclonal antibodies (MAbs) to tumor associated surface antigens of squamous cell carcinomas of the head and neck, monoclonal antibody K 931 was produced. The high affinity antibody (K(a) 5.0 x 1010 M-1) showed reactivity with 58 out of 62 squamous carcinomas of the head and neck. In contrast normal squamous epithelium as found in epidermis, oral cavity, epiglottis, pharynx, larynx and esophagus did not express the antigen. All other tested epithelial (simple and transitional) tissues did express the antigen, but non-epithelial tissues were negative. Further characterization revealed that the antigen represents the 17-1A antigen. A not earlier reported, enhanced expression of the 17-1A antigen was observed among some primary and all metastatic SCC.

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