TY - JOUR
T1 - Prognostic and therapeutic role of CLEC12A in acute myeloid leukemia
AU - Morsink, Linde M.
AU - Walter, Roland B.
AU - Ossenkoppele, Gert J.
PY - 2019/3
Y1 - 2019/3
N2 - CLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout diagnosis, treatment and relapse on leukemic blasts and leukemic stem cells, CLEC12A can be considered a highly potent and reliable marker for the detection of measurable residual disease and therefore applicable for risk stratification and prognostication in AML. Low CLEC12A expression on leukemic blasts seems to be independently associated with lower likelihood of achieving complete remission after 1 cycle of induction chemotherapy, shorter event free survival, as well as overall survival, indicating potential prognostic properties of CLEC12A expression itself. Lack of expression on the normal hematopoietic stem and progenitor cells, in contrast to CD123 and CD33, might result in less toxicity regarding cytopenias, making CLEC12A an interesting target for innovating immunotherapies, including monoclonal and bispecific antibodies, antibody-drug conjugates and CAR-T cells therapy.
AB - CLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout diagnosis, treatment and relapse on leukemic blasts and leukemic stem cells, CLEC12A can be considered a highly potent and reliable marker for the detection of measurable residual disease and therefore applicable for risk stratification and prognostication in AML. Low CLEC12A expression on leukemic blasts seems to be independently associated with lower likelihood of achieving complete remission after 1 cycle of induction chemotherapy, shorter event free survival, as well as overall survival, indicating potential prognostic properties of CLEC12A expression itself. Lack of expression on the normal hematopoietic stem and progenitor cells, in contrast to CD123 and CD33, might result in less toxicity regarding cytopenias, making CLEC12A an interesting target for innovating immunotherapies, including monoclonal and bispecific antibodies, antibody-drug conjugates and CAR-T cells therapy.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85055904368&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/30401586
U2 - 10.1016/j.blre.2018.10.003
DO - 10.1016/j.blre.2018.10.003
M3 - Review article
C2 - 30401586
VL - 34
SP - 26
EP - 33
JO - Blood Reviews
JF - Blood Reviews
SN - 0268-960X
ER -