Abstract

Background: Colorectal cancer is diagnosed progressively in employed patients due to screening programs and increasing retirement age. The objective of this study was to identify prognostic factors for return to work and work disability in patients with colorectal cancer. Methods: The research protocol was published at PROSPERO with registration number CRD42017049757. A systematic review of cohort and case-control studies in colorectal cancer patients above 18 years, who were employed when diagnosed, and who had a surgical resection with curative intent were included. The primary outcome was return to work or work disability. Potentially prognostic factors were included in the analysis if they were measured in at least three studies. Risk of bias was assessed according to the QUality In Prognosis Studies tool. A qualitative synthesis analysis was performed due to heterogeneity between studies. Quality of evidence was evaluated according to Grading of Recommendation Assessment, Development and Evaluation. Results: Eight studies were included with a follow-up period of 26 up to 520 weeks. (Neo)adjuvant therapy, higher age, and more comorbidities had a significant negative influence on return to work. A previous period of unemployment, extensive surgical resection and postoperative complications significantly increased the risk of work disability. The quality of evidence for these prognostic factors was considered very low to moderate. Conclusion: Health care professionals need to be aware of these prognostic factors to select patients eligible for timely intensified rehabilitation in order to optimize the return to work process and prevent work disability.
Original languageEnglish
Article numbere0200720
JournalPLoS ONE
Volume13
Issue number8
DOIs
Publication statusPublished - 2018

Cite this

@article{3d77f897a4e54c8f88c2c172cd529437,
title = "Prognostic factors for return to work and work disability among colorectal cancer survivors; A systematic review",
abstract = "Background: Colorectal cancer is diagnosed progressively in employed patients due to screening programs and increasing retirement age. The objective of this study was to identify prognostic factors for return to work and work disability in patients with colorectal cancer. Methods: The research protocol was published at PROSPERO with registration number CRD42017049757. A systematic review of cohort and case-control studies in colorectal cancer patients above 18 years, who were employed when diagnosed, and who had a surgical resection with curative intent were included. The primary outcome was return to work or work disability. Potentially prognostic factors were included in the analysis if they were measured in at least three studies. Risk of bias was assessed according to the QUality In Prognosis Studies tool. A qualitative synthesis analysis was performed due to heterogeneity between studies. Quality of evidence was evaluated according to Grading of Recommendation Assessment, Development and Evaluation. Results: Eight studies were included with a follow-up period of 26 up to 520 weeks. (Neo)adjuvant therapy, higher age, and more comorbidities had a significant negative influence on return to work. A previous period of unemployment, extensive surgical resection and postoperative complications significantly increased the risk of work disability. The quality of evidence for these prognostic factors was considered very low to moderate. Conclusion: Health care professionals need to be aware of these prognostic factors to select patients eligible for timely intensified rehabilitation in order to optimize the return to work process and prevent work disability.",
author = "{den Bakker}, {Chantal M.} and Anema, {Johannes R.} and Zaman, {AnneClaire G. N. M.} and {de Vet}, {Henrika C. W.} and Linda Sharp and Eva Angenete and Allaix, {Marco E.} and Otten, {Rene H. J.} and Huirne, {Judith A. F.} and Bonjer, {Hendrik J.} and {de Boer}, {Angela G. E. M.} and Schaafsma, {Frederieke G.}",
year = "2018",
doi = "10.1371/journal.pone.0200720",
language = "English",
volume = "13",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "8",

}

Prognostic factors for return to work and work disability among colorectal cancer survivors; A systematic review. / den Bakker, Chantal M.; Anema, Johannes R.; Zaman, AnneClaire G. N. M.; de Vet, Henrika C. W.; Sharp, Linda; Angenete, Eva; Allaix, Marco E.; Otten, Rene H. J.; Huirne, Judith A. F.; Bonjer, Hendrik J.; de Boer, Angela G. E. M.; Schaafsma, Frederieke G.

In: PLoS ONE, Vol. 13, No. 8, e0200720, 2018.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Prognostic factors for return to work and work disability among colorectal cancer survivors; A systematic review

AU - den Bakker, Chantal M.

AU - Anema, Johannes R.

AU - Zaman, AnneClaire G. N. M.

AU - de Vet, Henrika C. W.

AU - Sharp, Linda

AU - Angenete, Eva

AU - Allaix, Marco E.

AU - Otten, Rene H. J.

AU - Huirne, Judith A. F.

AU - Bonjer, Hendrik J.

AU - de Boer, Angela G. E. M.

AU - Schaafsma, Frederieke G.

PY - 2018

Y1 - 2018

N2 - Background: Colorectal cancer is diagnosed progressively in employed patients due to screening programs and increasing retirement age. The objective of this study was to identify prognostic factors for return to work and work disability in patients with colorectal cancer. Methods: The research protocol was published at PROSPERO with registration number CRD42017049757. A systematic review of cohort and case-control studies in colorectal cancer patients above 18 years, who were employed when diagnosed, and who had a surgical resection with curative intent were included. The primary outcome was return to work or work disability. Potentially prognostic factors were included in the analysis if they were measured in at least three studies. Risk of bias was assessed according to the QUality In Prognosis Studies tool. A qualitative synthesis analysis was performed due to heterogeneity between studies. Quality of evidence was evaluated according to Grading of Recommendation Assessment, Development and Evaluation. Results: Eight studies were included with a follow-up period of 26 up to 520 weeks. (Neo)adjuvant therapy, higher age, and more comorbidities had a significant negative influence on return to work. A previous period of unemployment, extensive surgical resection and postoperative complications significantly increased the risk of work disability. The quality of evidence for these prognostic factors was considered very low to moderate. Conclusion: Health care professionals need to be aware of these prognostic factors to select patients eligible for timely intensified rehabilitation in order to optimize the return to work process and prevent work disability.

AB - Background: Colorectal cancer is diagnosed progressively in employed patients due to screening programs and increasing retirement age. The objective of this study was to identify prognostic factors for return to work and work disability in patients with colorectal cancer. Methods: The research protocol was published at PROSPERO with registration number CRD42017049757. A systematic review of cohort and case-control studies in colorectal cancer patients above 18 years, who were employed when diagnosed, and who had a surgical resection with curative intent were included. The primary outcome was return to work or work disability. Potentially prognostic factors were included in the analysis if they were measured in at least three studies. Risk of bias was assessed according to the QUality In Prognosis Studies tool. A qualitative synthesis analysis was performed due to heterogeneity between studies. Quality of evidence was evaluated according to Grading of Recommendation Assessment, Development and Evaluation. Results: Eight studies were included with a follow-up period of 26 up to 520 weeks. (Neo)adjuvant therapy, higher age, and more comorbidities had a significant negative influence on return to work. A previous period of unemployment, extensive surgical resection and postoperative complications significantly increased the risk of work disability. The quality of evidence for these prognostic factors was considered very low to moderate. Conclusion: Health care professionals need to be aware of these prognostic factors to select patients eligible for timely intensified rehabilitation in order to optimize the return to work process and prevent work disability.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85053681682&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/30110333

U2 - 10.1371/journal.pone.0200720

DO - 10.1371/journal.pone.0200720

M3 - Review article

VL - 13

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 8

M1 - e0200720

ER -