Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension

Serge A van Wolferen; Johannes T Marcus; Anco Boonstra; Koen M J Marques; Jean G F Bronzwaer; Marieke D Spreeuwenberg; Pieter E Postmus; Anton Vonk-Noordegraaf

doi:10.1093/eurheartj/ehl477

Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension

Serge A van Wolferen, Johannes T Marcus, Anco Boonstra, Koen M J Marques, Jean G F Bronzwaer, Marieke D Spreeuwenberg, Pieter E Postmus, Anton Vonk-Noordegraaf

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

AIMS: This study investigated the relationship between right ventricular (RV) structure and function and survival in idiopathic pulmonary arterial hypertension (IPAH).

METHODS AND RESULTS: In 64 patients, cardiac magnetic resonance, right heart catheterization, and the six-minute walk test (6MWT) were performed at baseline and after 1-year follow-up. RV structure and function were analysed as predictors of mortality. During a mean follow-up of 32 months, 19 patients died. A low stroke volume (SV), RV dilatation, and impaired left ventricular (LV) filling independently predicted mortality. In addition, a further decrease in SV, progressive RV dilatation, and further decrease in LV end-diastolic volume (LVEDV) at 1-year follow-up were the strongest predictors of mortality. According to Kaplan-Meier survival curves, survival was lower in patients with an inframedian SV index <or= 25 mL/m(2), a supramedian RV end-diastolic volume index >or= 84 mL/m(2), and an inframedian LVEDV<or=40 mL/m(2).

CONCLUSIONS: The RV contains prognostic information in IPAH. A large RV volume, low SV, and a reduced LV volume are strong independent predictors of mortality and treatment failure.

Original language	English
Pages (from-to)	1250-7
Number of pages	8
Journal	European Heart Journal
Volume	28
Issue number	10
DOIs	https://doi.org/10.1093/eurheartj/ehl477
Publication status	Published - May 2007

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10.1093/eurheartj/ehl477

Cite this

@article{f6d404d8d9f64490aa59506377970884,

title = "Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension",

abstract = "AIMS: This study investigated the relationship between right ventricular (RV) structure and function and survival in idiopathic pulmonary arterial hypertension (IPAH).METHODS AND RESULTS: In 64 patients, cardiac magnetic resonance, right heart catheterization, and the six-minute walk test (6MWT) were performed at baseline and after 1-year follow-up. RV structure and function were analysed as predictors of mortality. During a mean follow-up of 32 months, 19 patients died. A low stroke volume (SV), RV dilatation, and impaired left ventricular (LV) filling independently predicted mortality. In addition, a further decrease in SV, progressive RV dilatation, and further decrease in LV end-diastolic volume (LVEDV) at 1-year follow-up were the strongest predictors of mortality. According to Kaplan-Meier survival curves, survival was lower in patients with an inframedian SV index or= 84 mL/m(2), and an inframedian LVEDVCONCLUSIONS: The RV contains prognostic information in IPAH. A large RV volume, low SV, and a reduced LV volume are strong independent predictors of mortality and treatment failure.",

keywords = "Adult, Cardiac Catheterization, Exercise Test, Female, Follow-Up Studies, Heart Ventricles/physiopathology, Humans, Hypertension, Pulmonary/diagnosis, Magnetic Resonance Imaging, Cine, Male, Prognosis, Pulmonary Artery/physiopathology, Risk Factors, Stroke Volume, Survival Analysis, Ventricular Dysfunction, Left/diagnosis, Ventricular Dysfunction, Right/diagnosis",

author = "{van Wolferen}, {Serge A} and Marcus, {Johannes T} and Anco Boonstra and Marques, {Koen M J} and Bronzwaer, {Jean G F} and Spreeuwenberg, {Marieke D} and Postmus, {Pieter E} and Anton Vonk-Noordegraaf",

year = "2007",

month = may,

doi = "10.1093/eurheartj/ehl477",

language = "English",

volume = "28",

pages = "1250--7",

journal = "European Heart Journal",

issn = "0195-668X",

publisher = "Oxford University Press",

number = "10",

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Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension. / van Wolferen, Serge A; Marcus, Johannes T ; Boonstra, Anco ; Marques, Koen M J; Bronzwaer, Jean G F; Spreeuwenberg, Marieke D; Postmus, Pieter E; Vonk-Noordegraaf, Anton.

In: European Heart Journal, Vol. 28, No. 10, 05.2007, p. 1250-7.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension

AU - van Wolferen, Serge A

AU - Marcus, Johannes T

AU - Boonstra, Anco

AU - Marques, Koen M J

AU - Bronzwaer, Jean G F

AU - Spreeuwenberg, Marieke D

AU - Postmus, Pieter E

AU - Vonk-Noordegraaf, Anton

PY - 2007/5

Y1 - 2007/5

N2 - AIMS: This study investigated the relationship between right ventricular (RV) structure and function and survival in idiopathic pulmonary arterial hypertension (IPAH).METHODS AND RESULTS: In 64 patients, cardiac magnetic resonance, right heart catheterization, and the six-minute walk test (6MWT) were performed at baseline and after 1-year follow-up. RV structure and function were analysed as predictors of mortality. During a mean follow-up of 32 months, 19 patients died. A low stroke volume (SV), RV dilatation, and impaired left ventricular (LV) filling independently predicted mortality. In addition, a further decrease in SV, progressive RV dilatation, and further decrease in LV end-diastolic volume (LVEDV) at 1-year follow-up were the strongest predictors of mortality. According to Kaplan-Meier survival curves, survival was lower in patients with an inframedian SV index or= 84 mL/m(2), and an inframedian LVEDVCONCLUSIONS: The RV contains prognostic information in IPAH. A large RV volume, low SV, and a reduced LV volume are strong independent predictors of mortality and treatment failure.

AB - AIMS: This study investigated the relationship between right ventricular (RV) structure and function and survival in idiopathic pulmonary arterial hypertension (IPAH).METHODS AND RESULTS: In 64 patients, cardiac magnetic resonance, right heart catheterization, and the six-minute walk test (6MWT) were performed at baseline and after 1-year follow-up. RV structure and function were analysed as predictors of mortality. During a mean follow-up of 32 months, 19 patients died. A low stroke volume (SV), RV dilatation, and impaired left ventricular (LV) filling independently predicted mortality. In addition, a further decrease in SV, progressive RV dilatation, and further decrease in LV end-diastolic volume (LVEDV) at 1-year follow-up were the strongest predictors of mortality. According to Kaplan-Meier survival curves, survival was lower in patients with an inframedian SV index or= 84 mL/m(2), and an inframedian LVEDVCONCLUSIONS: The RV contains prognostic information in IPAH. A large RV volume, low SV, and a reduced LV volume are strong independent predictors of mortality and treatment failure.

KW - Adult

KW - Cardiac Catheterization

KW - Exercise Test

KW - Female

KW - Follow-Up Studies

KW - Heart Ventricles/physiopathology

KW - Humans

KW - Hypertension, Pulmonary/diagnosis

KW - Magnetic Resonance Imaging, Cine

KW - Male

KW - Prognosis

KW - Pulmonary Artery/physiopathology

KW - Risk Factors

KW - Stroke Volume

KW - Survival Analysis

KW - Ventricular Dysfunction, Left/diagnosis

KW - Ventricular Dysfunction, Right/diagnosis

U2 - 10.1093/eurheartj/ehl477

DO - 10.1093/eurheartj/ehl477

M3 - Article

C2 - 17242010

VL - 28

SP - 1250

EP - 1257

JO - European Heart Journal

JF - European Heart Journal

SN - 0195-668X

IS - 10

ER -