TY - JOUR
T1 - Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension
AU - van Wolferen, Serge A
AU - Marcus, Johannes T
AU - Boonstra, Anco
AU - Marques, Koen M J
AU - Bronzwaer, Jean G F
AU - Spreeuwenberg, Marieke D
AU - Postmus, Pieter E
AU - Vonk-Noordegraaf, Anton
PY - 2007/5
Y1 - 2007/5
N2 - AIMS: This study investigated the relationship between right ventricular (RV) structure and function and survival in idiopathic pulmonary arterial hypertension (IPAH).METHODS AND RESULTS: In 64 patients, cardiac magnetic resonance, right heart catheterization, and the six-minute walk test (6MWT) were performed at baseline and after 1-year follow-up. RV structure and function were analysed as predictors of mortality. During a mean follow-up of 32 months, 19 patients died. A low stroke volume (SV), RV dilatation, and impaired left ventricular (LV) filling independently predicted mortality. In addition, a further decrease in SV, progressive RV dilatation, and further decrease in LV end-diastolic volume (LVEDV) at 1-year follow-up were the strongest predictors of mortality. According to Kaplan-Meier survival curves, survival was lower in patients with an inframedian SV index or= 84 mL/m(2), and an inframedian LVEDVCONCLUSIONS: The RV contains prognostic information in IPAH. A large RV volume, low SV, and a reduced LV volume are strong independent predictors of mortality and treatment failure.
AB - AIMS: This study investigated the relationship between right ventricular (RV) structure and function and survival in idiopathic pulmonary arterial hypertension (IPAH).METHODS AND RESULTS: In 64 patients, cardiac magnetic resonance, right heart catheterization, and the six-minute walk test (6MWT) were performed at baseline and after 1-year follow-up. RV structure and function were analysed as predictors of mortality. During a mean follow-up of 32 months, 19 patients died. A low stroke volume (SV), RV dilatation, and impaired left ventricular (LV) filling independently predicted mortality. In addition, a further decrease in SV, progressive RV dilatation, and further decrease in LV end-diastolic volume (LVEDV) at 1-year follow-up were the strongest predictors of mortality. According to Kaplan-Meier survival curves, survival was lower in patients with an inframedian SV index or= 84 mL/m(2), and an inframedian LVEDVCONCLUSIONS: The RV contains prognostic information in IPAH. A large RV volume, low SV, and a reduced LV volume are strong independent predictors of mortality and treatment failure.
KW - Adult
KW - Cardiac Catheterization
KW - Exercise Test
KW - Female
KW - Follow-Up Studies
KW - Heart Ventricles/physiopathology
KW - Humans
KW - Hypertension, Pulmonary/diagnosis
KW - Magnetic Resonance Imaging, Cine
KW - Male
KW - Prognosis
KW - Pulmonary Artery/physiopathology
KW - Risk Factors
KW - Stroke Volume
KW - Survival Analysis
KW - Ventricular Dysfunction, Left/diagnosis
KW - Ventricular Dysfunction, Right/diagnosis
U2 - 10.1093/eurheartj/ehl477
DO - 10.1093/eurheartj/ehl477
M3 - Article
C2 - 17242010
VL - 28
SP - 1250
EP - 1257
JO - European Heart Journal
JF - European Heart Journal
SN - 0195-668X
IS - 10
ER -