Progression delay of prostate tumor skeletal metastasis effects by bisphosphonates

S. Yu-Cheng, A. A. Geldof, D. W.W. Newling, B. R. Rao*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Prostate tumor cell metastasis to the axial skeleton was induced in male Copenhagen rats using the intravenous injection of syngeneic metastatic R3327-MATLyLu tumor cells and concomitant caval vein clamping. The proliferation of tumor cells in the lumbar region was monitored by the progression, within 19 days post tumor cell injection, of hindleg paralysis which appeared in these animals. Histology confirmed the presence of tumor cells within the lumbar spine in 100% of cases displaying hindleg paralysis. Treatment with either of the bisphosphonate drugs, Cl2MDP or APD, suppressed and delayed the development of hind leg paralysis. Bisphosphonate treatment may be expected to delay the onset of axial skeletal metastasis effects in prostate cancer patients.

Original languageEnglish
Pages (from-to)1270-1273
Number of pages4
JournalJournal of Urology
Issue number4
Publication statusPublished - 1 Jan 1992

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