Progressive multifokale Leukenzephalopathie

C. Warnke; M. P. Wattjes; O. Adams; H. P. Hartung; R. Martin; T. Weber; M. Stangel

doi:10.1007/s00115-016-0225-7

Progressive multifokale Leukenzephalopathie

Translated title of the contribution: Progressive multifocal leukoencephalopathy

C. Warnke^*, M. P. Wattjes, O. Adams, H. P. Hartung, R. Martin, T. Weber, M. Stangel

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Progressive multifocal leukoencephalopathy (PML) is a disease of immunosuppressed patients caused by the JC polyomavirus (JCPyV). Due to the elevated risk in patients treated with natalizumab for multiple sclerosis (MS) and also treatment with other biologicals for different indications, the relevance of PML has increased in recent years. This article summarizes the published knowledge on the biology and pathogenesis of PML with a focus on the role of cerebrospinal fluid diagnostics in the work-up for PML and the current PML case definition. Current recommendations regarding risk management are discussed, as are possible therapies and prevention.

Translated title of the contribution	Progressive multifocal leukoencephalopathy
Original language	German
Pages (from-to)	1300-1304
Number of pages	5
Journal	Nervenarzt
Volume	87
Issue number	12
DOIs	https://doi.org/10.1007/s00115-016-0225-7
Publication status	Published - 1 Dec 2016

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title = "Progressive multifokale Leukenzephalopathie",

abstract = "Progressive multifocal leukoencephalopathy (PML) is a disease of immunosuppressed patients caused by the JC polyomavirus (JCPyV). Due to the elevated risk in patients treated with natalizumab for multiple sclerosis (MS) and also treatment with other biologicals for different indications, the relevance of PML has increased in recent years. This article summarizes the published knowledge on the biology and pathogenesis of PML with a focus on the role of cerebrospinal fluid diagnostics in the work-up for PML and the current PML case definition. Current recommendations regarding risk management are discussed, as are possible therapies and prevention.",

keywords = "Cerebrospinal fluid, JC polyomavirus, Multiple sclerosis, Natalizumab, PML",

author = "C. Warnke and Wattjes, {M. P.} and O. Adams and Hartung, {H. P.} and R. Martin and T. Weber and M. Stangel",

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doi = "10.1007/s00115-016-0225-7",

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AU - Warnke, C.

AU - Wattjes, M. P.

AU - Adams, O.

AU - Hartung, H. P.

AU - Martin, R.

AU - Weber, T.

AU - Stangel, M.

PY - 2016/12/1

Y1 - 2016/12/1

N2 - Progressive multifocal leukoencephalopathy (PML) is a disease of immunosuppressed patients caused by the JC polyomavirus (JCPyV). Due to the elevated risk in patients treated with natalizumab for multiple sclerosis (MS) and also treatment with other biologicals for different indications, the relevance of PML has increased in recent years. This article summarizes the published knowledge on the biology and pathogenesis of PML with a focus on the role of cerebrospinal fluid diagnostics in the work-up for PML and the current PML case definition. Current recommendations regarding risk management are discussed, as are possible therapies and prevention.

AB - Progressive multifocal leukoencephalopathy (PML) is a disease of immunosuppressed patients caused by the JC polyomavirus (JCPyV). Due to the elevated risk in patients treated with natalizumab for multiple sclerosis (MS) and also treatment with other biologicals for different indications, the relevance of PML has increased in recent years. This article summarizes the published knowledge on the biology and pathogenesis of PML with a focus on the role of cerebrospinal fluid diagnostics in the work-up for PML and the current PML case definition. Current recommendations regarding risk management are discussed, as are possible therapies and prevention.

KW - Cerebrospinal fluid

KW - JC polyomavirus

KW - Multiple sclerosis

KW - Natalizumab

KW - PML

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EP - 1304

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JF - Nervenarzt

SN - 0028-2804

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ER -

Progressive multifokale Leukenzephalopathie

Abstract

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