Prolonged time between intravenous contrast administration and image acquisition results in increased synovial thickness at magnetic resonance imaging in patients with juvenile idiopathic arthritis

Anouk M. Barendregt, E. Charlotte van Gulik, Paul F. C. Groot, Koert M. Dolman, J. Merlijn van den Berg, Amara Nassar-Sheikh Rashid, Dieneke Schonenberg-Meinema, Cristina Lavini, Karen Rosendahl, Robert Hemke, Taco W. Kuijpers, Mario Maas, Charlotte M. Nusman

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background: Post-contrast synovial thickness measurement is necessary for scoring disease activity in juvenile idiopathic arthritis (JIA). However, the timing of post-contrast sequences varies widely among institutions. This variation in timing could influence thickness measurements. Objective: To measure thickness of the synovial membrane on early and late post-contrast knee magnetic resonance (MR) images of patients with JIA. Materials and methods: Dynamic contrast-enhanced T1-weighted knee MR images of 53 children with JIA with current or past knee arthritis were used to study synovial thickness at time point 1 (about 1 min) and time point 2 (about 5 min after contrast administration). Two experienced readers, who were blinded for the time point, independently measured synovial thickness at a predefined, marked location in the patellofemoral compartment on randomized images. Synovial thickness at the two time points was compared using the Wilcoxon signed rank test. Repeatibility of the synovial thickness measurements was studied using intraclass correlation coefficients and Bland-Altman plots. Results: Median synovial thickness of the 53 patients (median age: 13.5 years, 59% female) increased with prolonged post-contrast interval with a synovial thickness of 1.4 mm at time point 1 and a synovial thickness of 1.5 mm at time point 2 (P<0.001). Repeated synovial thickness measurements showed an intraclass correlation coefficient (ICC) of 0.75, P<0.05 for time point 1 and an ICC of 0.91, P<0.05 for time point 2. Conclusion: Post-contrast synovial membrane thickness measurements are time-dependent. Therefore, standardization of post-contrast image acquisition timing is important to achieve consistent grading of synovial inflammation.
Original languageEnglish
Pages (from-to)638-645
JournalPediatric Radiology
Volume49
Issue number5
DOIs
Publication statusPublished - 1 May 2019

Cite this

@article{d1ad9b514acb4b01af81e25098695d9a,
title = "Prolonged time between intravenous contrast administration and image acquisition results in increased synovial thickness at magnetic resonance imaging in patients with juvenile idiopathic arthritis",
abstract = "Background: Post-contrast synovial thickness measurement is necessary for scoring disease activity in juvenile idiopathic arthritis (JIA). However, the timing of post-contrast sequences varies widely among institutions. This variation in timing could influence thickness measurements. Objective: To measure thickness of the synovial membrane on early and late post-contrast knee magnetic resonance (MR) images of patients with JIA. Materials and methods: Dynamic contrast-enhanced T1-weighted knee MR images of 53 children with JIA with current or past knee arthritis were used to study synovial thickness at time point 1 (about 1 min) and time point 2 (about 5 min after contrast administration). Two experienced readers, who were blinded for the time point, independently measured synovial thickness at a predefined, marked location in the patellofemoral compartment on randomized images. Synovial thickness at the two time points was compared using the Wilcoxon signed rank test. Repeatibility of the synovial thickness measurements was studied using intraclass correlation coefficients and Bland-Altman plots. Results: Median synovial thickness of the 53 patients (median age: 13.5 years, 59{\%} female) increased with prolonged post-contrast interval with a synovial thickness of 1.4 mm at time point 1 and a synovial thickness of 1.5 mm at time point 2 (P<0.001). Repeated synovial thickness measurements showed an intraclass correlation coefficient (ICC) of 0.75, P<0.05 for time point 1 and an ICC of 0.91, P<0.05 for time point 2. Conclusion: Post-contrast synovial membrane thickness measurements are time-dependent. Therefore, standardization of post-contrast image acquisition timing is important to achieve consistent grading of synovial inflammation.",
author = "Barendregt, {Anouk M.} and {van Gulik}, {E. Charlotte} and Groot, {Paul F. C.} and Dolman, {Koert M.} and {van den Berg}, {J. Merlijn} and {Nassar-Sheikh Rashid}, Amara and Dieneke Schonenberg-Meinema and Cristina Lavini and Karen Rosendahl and Robert Hemke and Kuijpers, {Taco W.} and Mario Maas and Nusman, {Charlotte M.}",
year = "2019",
month = "5",
day = "1",
doi = "10.1007/s00247-018-04332-x",
language = "English",
volume = "49",
pages = "638--645",
journal = "Pediatric Radiology",
issn = "0301-0449",
publisher = "Springer Verlag",
number = "5",

}

Prolonged time between intravenous contrast administration and image acquisition results in increased synovial thickness at magnetic resonance imaging in patients with juvenile idiopathic arthritis. / Barendregt, Anouk M.; van Gulik, E. Charlotte; Groot, Paul F. C.; Dolman, Koert M.; van den Berg, J. Merlijn; Nassar-Sheikh Rashid, Amara; Schonenberg-Meinema, Dieneke; Lavini, Cristina; Rosendahl, Karen; Hemke, Robert; Kuijpers, Taco W.; Maas, Mario; Nusman, Charlotte M.

In: Pediatric Radiology, Vol. 49, No. 5, 01.05.2019, p. 638-645.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Prolonged time between intravenous contrast administration and image acquisition results in increased synovial thickness at magnetic resonance imaging in patients with juvenile idiopathic arthritis

AU - Barendregt, Anouk M.

AU - van Gulik, E. Charlotte

AU - Groot, Paul F. C.

AU - Dolman, Koert M.

AU - van den Berg, J. Merlijn

AU - Nassar-Sheikh Rashid, Amara

AU - Schonenberg-Meinema, Dieneke

AU - Lavini, Cristina

AU - Rosendahl, Karen

AU - Hemke, Robert

AU - Kuijpers, Taco W.

AU - Maas, Mario

AU - Nusman, Charlotte M.

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Background: Post-contrast synovial thickness measurement is necessary for scoring disease activity in juvenile idiopathic arthritis (JIA). However, the timing of post-contrast sequences varies widely among institutions. This variation in timing could influence thickness measurements. Objective: To measure thickness of the synovial membrane on early and late post-contrast knee magnetic resonance (MR) images of patients with JIA. Materials and methods: Dynamic contrast-enhanced T1-weighted knee MR images of 53 children with JIA with current or past knee arthritis were used to study synovial thickness at time point 1 (about 1 min) and time point 2 (about 5 min after contrast administration). Two experienced readers, who were blinded for the time point, independently measured synovial thickness at a predefined, marked location in the patellofemoral compartment on randomized images. Synovial thickness at the two time points was compared using the Wilcoxon signed rank test. Repeatibility of the synovial thickness measurements was studied using intraclass correlation coefficients and Bland-Altman plots. Results: Median synovial thickness of the 53 patients (median age: 13.5 years, 59% female) increased with prolonged post-contrast interval with a synovial thickness of 1.4 mm at time point 1 and a synovial thickness of 1.5 mm at time point 2 (P<0.001). Repeated synovial thickness measurements showed an intraclass correlation coefficient (ICC) of 0.75, P<0.05 for time point 1 and an ICC of 0.91, P<0.05 for time point 2. Conclusion: Post-contrast synovial membrane thickness measurements are time-dependent. Therefore, standardization of post-contrast image acquisition timing is important to achieve consistent grading of synovial inflammation.

AB - Background: Post-contrast synovial thickness measurement is necessary for scoring disease activity in juvenile idiopathic arthritis (JIA). However, the timing of post-contrast sequences varies widely among institutions. This variation in timing could influence thickness measurements. Objective: To measure thickness of the synovial membrane on early and late post-contrast knee magnetic resonance (MR) images of patients with JIA. Materials and methods: Dynamic contrast-enhanced T1-weighted knee MR images of 53 children with JIA with current or past knee arthritis were used to study synovial thickness at time point 1 (about 1 min) and time point 2 (about 5 min after contrast administration). Two experienced readers, who were blinded for the time point, independently measured synovial thickness at a predefined, marked location in the patellofemoral compartment on randomized images. Synovial thickness at the two time points was compared using the Wilcoxon signed rank test. Repeatibility of the synovial thickness measurements was studied using intraclass correlation coefficients and Bland-Altman plots. Results: Median synovial thickness of the 53 patients (median age: 13.5 years, 59% female) increased with prolonged post-contrast interval with a synovial thickness of 1.4 mm at time point 1 and a synovial thickness of 1.5 mm at time point 2 (P<0.001). Repeated synovial thickness measurements showed an intraclass correlation coefficient (ICC) of 0.75, P<0.05 for time point 1 and an ICC of 0.91, P<0.05 for time point 2. Conclusion: Post-contrast synovial membrane thickness measurements are time-dependent. Therefore, standardization of post-contrast image acquisition timing is important to achieve consistent grading of synovial inflammation.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/30707259

U2 - 10.1007/s00247-018-04332-x

DO - 10.1007/s00247-018-04332-x

M3 - Article

VL - 49

SP - 638

EP - 645

JO - Pediatric Radiology

JF - Pediatric Radiology

SN - 0301-0449

IS - 5

ER -