Proposals for revised IWG 2018 hematological response criteria in patients with MDS included in clinical trials

U. Platzbecker, P. Fenaux, L. Adès, A. Giagounidis, V. Santini, A. A. van de Loosdrecht, D. Bowen, T. de Witte, G. Garcia-Manero, E. Hellström-Lindberg, U. Germing, R. Stauder, L. Malcovati, Mikkael A. Sekeres, David P. Steensma, S. Gloaguen

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

The heterogeneity of myelodysplastic syndromes (MDSs) has made evaluating patient response to treatment challenging. In 2006, the International Working Group (IWG) proposed a revision to previously published standardized response criteria (IWG 2000) for uniformly evaluating clinical responses in MDSs. These IWG 2006 criteria have been used prospectively in many clinical trials in MDSs, but proved challenging in several of them, especially for the evaluation of erythroid response. In this report, we provide rationale for modifications (IWG 2018) of these recommendations, mainly for "hematological improvement" criteria used for lower-risk MDSs, based on recent practical and reported experience in clinical trials. Most suggestions relate to erythroid response assessment, which are refined in an overall more stringent manner. Two major proposed changes are the differentiation between "procedures" and "criteria" for hematologic improvement-erythroid assessment and a new categorization of transfusion-burden subgroups.
Original languageEnglish
Pages (from-to)1020-1030
JournalBlood
Volume133
Issue number10
DOIs
Publication statusPublished - 2019

Cite this

Platzbecker, U. ; Fenaux, P. ; Adès, L. ; Giagounidis, A. ; Santini, V. ; van de Loosdrecht, A. A. ; Bowen, D. ; de Witte, T. ; Garcia-Manero, G. ; Hellström-Lindberg, E. ; Germing, U. ; Stauder, R. ; Malcovati, L. ; Sekeres, Mikkael A. ; Steensma, David P. ; Gloaguen, S. / Proposals for revised IWG 2018 hematological response criteria in patients with MDS included in clinical trials. In: Blood. 2019 ; Vol. 133, No. 10. pp. 1020-1030.
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title = "Proposals for revised IWG 2018 hematological response criteria in patients with MDS included in clinical trials",
abstract = "The heterogeneity of myelodysplastic syndromes (MDSs) has made evaluating patient response to treatment challenging. In 2006, the International Working Group (IWG) proposed a revision to previously published standardized response criteria (IWG 2000) for uniformly evaluating clinical responses in MDSs. These IWG 2006 criteria have been used prospectively in many clinical trials in MDSs, but proved challenging in several of them, especially for the evaluation of erythroid response. In this report, we provide rationale for modifications (IWG 2018) of these recommendations, mainly for {"}hematological improvement{"} criteria used for lower-risk MDSs, based on recent practical and reported experience in clinical trials. Most suggestions relate to erythroid response assessment, which are refined in an overall more stringent manner. Two major proposed changes are the differentiation between {"}procedures{"} and {"}criteria{"} for hematologic improvement-erythroid assessment and a new categorization of transfusion-burden subgroups.",
author = "U. Platzbecker and P. Fenaux and L. Ad{\`e}s and A. Giagounidis and V. Santini and {van de Loosdrecht}, {A. A.} and D. Bowen and {de Witte}, T. and G. Garcia-Manero and E. Hellstr{\"o}m-Lindberg and U. Germing and R. Stauder and L. Malcovati and Sekeres, {Mikkael A.} and Steensma, {David P.} and S. Gloaguen",
year = "2019",
doi = "10.1182/blood-2018-06-857102",
language = "English",
volume = "133",
pages = "1020--1030",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
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Platzbecker, U, Fenaux, P, Adès, L, Giagounidis, A, Santini, V, van de Loosdrecht, AA, Bowen, D, de Witte, T, Garcia-Manero, G, Hellström-Lindberg, E, Germing, U, Stauder, R, Malcovati, L, Sekeres, MA, Steensma, DP & Gloaguen, S 2019, 'Proposals for revised IWG 2018 hematological response criteria in patients with MDS included in clinical trials' Blood, vol. 133, no. 10, pp. 1020-1030. https://doi.org/10.1182/blood-2018-06-857102

Proposals for revised IWG 2018 hematological response criteria in patients with MDS included in clinical trials. / Platzbecker, U.; Fenaux, P.; Adès, L.; Giagounidis, A.; Santini, V.; van de Loosdrecht, A. A.; Bowen, D.; de Witte, T.; Garcia-Manero, G.; Hellström-Lindberg, E.; Germing, U.; Stauder, R.; Malcovati, L.; Sekeres, Mikkael A.; Steensma, David P.; Gloaguen, S.

In: Blood, Vol. 133, No. 10, 2019, p. 1020-1030.

Research output: Contribution to journalReview articleAcademicpeer-review

TY - JOUR

T1 - Proposals for revised IWG 2018 hematological response criteria in patients with MDS included in clinical trials

AU - Platzbecker, U.

AU - Fenaux, P.

AU - Adès, L.

AU - Giagounidis, A.

AU - Santini, V.

AU - van de Loosdrecht, A. A.

AU - Bowen, D.

AU - de Witte, T.

AU - Garcia-Manero, G.

AU - Hellström-Lindberg, E.

AU - Germing, U.

AU - Stauder, R.

AU - Malcovati, L.

AU - Sekeres, Mikkael A.

AU - Steensma, David P.

AU - Gloaguen, S.

PY - 2019

Y1 - 2019

N2 - The heterogeneity of myelodysplastic syndromes (MDSs) has made evaluating patient response to treatment challenging. In 2006, the International Working Group (IWG) proposed a revision to previously published standardized response criteria (IWG 2000) for uniformly evaluating clinical responses in MDSs. These IWG 2006 criteria have been used prospectively in many clinical trials in MDSs, but proved challenging in several of them, especially for the evaluation of erythroid response. In this report, we provide rationale for modifications (IWG 2018) of these recommendations, mainly for "hematological improvement" criteria used for lower-risk MDSs, based on recent practical and reported experience in clinical trials. Most suggestions relate to erythroid response assessment, which are refined in an overall more stringent manner. Two major proposed changes are the differentiation between "procedures" and "criteria" for hematologic improvement-erythroid assessment and a new categorization of transfusion-burden subgroups.

AB - The heterogeneity of myelodysplastic syndromes (MDSs) has made evaluating patient response to treatment challenging. In 2006, the International Working Group (IWG) proposed a revision to previously published standardized response criteria (IWG 2000) for uniformly evaluating clinical responses in MDSs. These IWG 2006 criteria have been used prospectively in many clinical trials in MDSs, but proved challenging in several of them, especially for the evaluation of erythroid response. In this report, we provide rationale for modifications (IWG 2018) of these recommendations, mainly for "hematological improvement" criteria used for lower-risk MDSs, based on recent practical and reported experience in clinical trials. Most suggestions relate to erythroid response assessment, which are refined in an overall more stringent manner. Two major proposed changes are the differentiation between "procedures" and "criteria" for hematologic improvement-erythroid assessment and a new categorization of transfusion-burden subgroups.

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UR - https://www.ncbi.nlm.nih.gov/pubmed/30404811

U2 - 10.1182/blood-2018-06-857102

DO - 10.1182/blood-2018-06-857102

M3 - Review article

VL - 133

SP - 1020

EP - 1030

JO - Blood

JF - Blood

SN - 0006-4971

IS - 10

ER -