Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition

Christos Mikropoulos, Christina G. Hutten Selkirk, Sibel Saya, Elizabeth Bancroft, Emily Vertosick, Tokhir Dadaev, Charles Brendler, Elizabeth Page, Alexander Dias, D. Gareth Evans, Jeanette Rothwell, Lovise Maehle, Karol Axcrona, Kate Richardson, Diana Eccles, Thomas Jensen, Palle J. Osther, Christi J. van Asperen, Hans Vasen, Lambertus A. Kiemeney & 100 others Janneke Ringelberg, Cezary Cybulski, Dominika Wokolorczyk, Rachel Hart, Wayne Glover, Jimmy Lam, Louise Taylor, Monica Salinas, Lidia Feliubadaló, Rogier Oldenburg, Ruben Cremers, Gerald Verhaegh, Wendy A. van Zelst-Stams, Jan C. Oosterwijk, Jackie Cook, Derek J. Rosario, Saundra S. Buys, Tom Conner, Susan Domchek, Jacquelyn Powers, Margreet Gem Ausems, Manuel R. Teixeira, Sofia Maia, Louise Izatt, Rita Schmutzler, Kerstin Rhiem, William D. Foulkes, Talia Boshari, Rosemarie Davidson, Marielle Ruijs, Apollonia Tjm Helderman-van den Enden, Lesley Andrews, Lisa Walker, Katie Snape, Alex Henderson, Irene Jobson, Geoffrey J. Lindeman, Annelie Liljegren, Marion Harris, Muriel A. Adank, Judy Kirk, Amy Taylor, Rachel Susman, Rakefet Chen-Shtoyerman, Nicholas Pachter, Allan Spigelman, Lucy Side, Janez Zgajnar, Josefina Mora, Carole Brewer, Neus Gadea, Angela F. Brady, David Gallagher, Theo van Os, Alan Donaldson, Vigdis Stefansdottir, Julian Barwell, Paul A. James, Declan Murphy, Eitan Friedman, Nicola Nicolai, Lynn Greenhalgh, Elias Obeid, Vedang Murthy, Lucia Copakova, John McGrath, Soo-Hwang Teo, Sara Strom, Karin Kast, Daniel A. Leongamornlert, Anthony Chamberlain, Jenny Pope, Anna C. Newlin, Neil Aaronson, Audrey Ardern-Jones, Chris Bangma, Elena Castro, David Dearnaley, Jorunn Eyfjord, Alison Falconer, Christopher S. Foster, Henrik Gronberg, Freddie C. Hamdy, Oskar Johannsson, Vincent Khoo, Jan Lubinski, Eli Marie Grindedal, Joanne McKinley, Kylie Shackleton, Anita V. Mitra, Clare Moynihan, Gad Rennert, Mohnish Suri, Karen Tricker, Sue Moss, Zsofia Kote-Jarai, Andrew Vickers, Hans Lilja, Brian T. Helfand, Rosalind A. Eeles

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Background:Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition to PrCa due to BRCA1/2 mutations. This analysis evaluates the utility of PSA and PSAV for identifying PrCa and high-grade disease in this cohort.Methods:PSAV was calculated using logistic regression to determine if PSA or PSAV predicted the result of prostate biopsy (PB) in men with elevated PSA values. Cox regression was used to determine whether PSA or PSAV predicted PSA elevation in men with low PSAs. Interaction terms were included in the models to determine whether BRCA status influenced the predictiveness of PSA or PSAV.Results:1634 participants had 3/43 PSA readings of whom 174 underwent PB and 45 PrCas diagnosed. In men with PSA >3.0 ng ml -l, PSAV was not significantly associated with presence of cancer or high-grade disease. PSAV did not add to PSA for predicting time to an elevated PSA. When comparing BRCA1/2 carriers to non-carriers, we found a significant interaction between BRCA status and last PSA before biopsy (P=0.031) and BRCA2 status and PSAV (P=0.024). However, PSAV was not predictive of biopsy outcome in BRCA2 carriers.Conclusions:PSA is more strongly predictive of PrCa in BRCA carriers than non-carriers. We did not find evidence that PSAV aids decision-making for BRCA carriers over absolute PSA value alone.
Original languageEnglish
Pages (from-to)266-276
JournalBritish Journal of Cancer
Volume118
Issue number2
DOIs
Publication statusPublished - 2018

Cite this

Mikropoulos, C., Selkirk, C. G. H., Saya, S., Bancroft, E., Vertosick, E., Dadaev, T., ... Eeles, R. A. (2018). Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition. British Journal of Cancer, 118(2), 266-276. https://doi.org/10.1038/bjc.2017.429
Mikropoulos, Christos ; Selkirk, Christina G. Hutten ; Saya, Sibel ; Bancroft, Elizabeth ; Vertosick, Emily ; Dadaev, Tokhir ; Brendler, Charles ; Page, Elizabeth ; Dias, Alexander ; Evans, D. Gareth ; Rothwell, Jeanette ; Maehle, Lovise ; Axcrona, Karol ; Richardson, Kate ; Eccles, Diana ; Jensen, Thomas ; Osther, Palle J. ; van Asperen, Christi J. ; Vasen, Hans ; Kiemeney, Lambertus A. ; Ringelberg, Janneke ; Cybulski, Cezary ; Wokolorczyk, Dominika ; Hart, Rachel ; Glover, Wayne ; Lam, Jimmy ; Taylor, Louise ; Salinas, Monica ; Feliubadaló, Lidia ; Oldenburg, Rogier ; Cremers, Ruben ; Verhaegh, Gerald ; van Zelst-Stams, Wendy A. ; Oosterwijk, Jan C. ; Cook, Jackie ; Rosario, Derek J. ; Buys, Saundra S. ; Conner, Tom ; Domchek, Susan ; Powers, Jacquelyn ; Ausems, Margreet Gem ; Teixeira, Manuel R. ; Maia, Sofia ; Izatt, Louise ; Schmutzler, Rita ; Rhiem, Kerstin ; Foulkes, William D. ; Boshari, Talia ; Davidson, Rosemarie ; Ruijs, Marielle ; Helderman-van den Enden, Apollonia Tjm ; Andrews, Lesley ; Walker, Lisa ; Snape, Katie ; Henderson, Alex ; Jobson, Irene ; Lindeman, Geoffrey J. ; Liljegren, Annelie ; Harris, Marion ; Adank, Muriel A. ; Kirk, Judy ; Taylor, Amy ; Susman, Rachel ; Chen-Shtoyerman, Rakefet ; Pachter, Nicholas ; Spigelman, Allan ; Side, Lucy ; Zgajnar, Janez ; Mora, Josefina ; Brewer, Carole ; Gadea, Neus ; Brady, Angela F. ; Gallagher, David ; van Os, Theo ; Donaldson, Alan ; Stefansdottir, Vigdis ; Barwell, Julian ; James, Paul A. ; Murphy, Declan ; Friedman, Eitan ; Nicolai, Nicola ; Greenhalgh, Lynn ; Obeid, Elias ; Murthy, Vedang ; Copakova, Lucia ; McGrath, John ; Teo, Soo-Hwang ; Strom, Sara ; Kast, Karin ; Leongamornlert, Daniel A. ; Chamberlain, Anthony ; Pope, Jenny ; Newlin, Anna C. ; Aaronson, Neil ; Ardern-Jones, Audrey ; Bangma, Chris ; Castro, Elena ; Dearnaley, David ; Eyfjord, Jorunn ; Falconer, Alison ; Foster, Christopher S. ; Gronberg, Henrik ; Hamdy, Freddie C. ; Johannsson, Oskar ; Khoo, Vincent ; Lubinski, Jan ; Grindedal, Eli Marie ; McKinley, Joanne ; Shackleton, Kylie ; Mitra, Anita V. ; Moynihan, Clare ; Rennert, Gad ; Suri, Mohnish ; Tricker, Karen ; Moss, Sue ; Kote-Jarai, Zsofia ; Vickers, Andrew ; Lilja, Hans ; Helfand, Brian T. ; Eeles, Rosalind A. / Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition. In: British Journal of Cancer. 2018 ; Vol. 118, No. 2. pp. 266-276.
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title = "Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition",
abstract = "Background:Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition to PrCa due to BRCA1/2 mutations. This analysis evaluates the utility of PSA and PSAV for identifying PrCa and high-grade disease in this cohort.Methods:PSAV was calculated using logistic regression to determine if PSA or PSAV predicted the result of prostate biopsy (PB) in men with elevated PSA values. Cox regression was used to determine whether PSA or PSAV predicted PSA elevation in men with low PSAs. Interaction terms were included in the models to determine whether BRCA status influenced the predictiveness of PSA or PSAV.Results:1634 participants had 3/43 PSA readings of whom 174 underwent PB and 45 PrCas diagnosed. In men with PSA >3.0 ng ml -l, PSAV was not significantly associated with presence of cancer or high-grade disease. PSAV did not add to PSA for predicting time to an elevated PSA. When comparing BRCA1/2 carriers to non-carriers, we found a significant interaction between BRCA status and last PSA before biopsy (P=0.031) and BRCA2 status and PSAV (P=0.024). However, PSAV was not predictive of biopsy outcome in BRCA2 carriers.Conclusions:PSA is more strongly predictive of PrCa in BRCA carriers than non-carriers. We did not find evidence that PSAV aids decision-making for BRCA carriers over absolute PSA value alone.",
author = "Christos Mikropoulos and Selkirk, {Christina G. Hutten} and Sibel Saya and Elizabeth Bancroft and Emily Vertosick and Tokhir Dadaev and Charles Brendler and Elizabeth Page and Alexander Dias and Evans, {D. Gareth} and Jeanette Rothwell and Lovise Maehle and Karol Axcrona and Kate Richardson and Diana Eccles and Thomas Jensen and Osther, {Palle J.} and {van Asperen}, {Christi J.} and Hans Vasen and Kiemeney, {Lambertus A.} and Janneke Ringelberg and Cezary Cybulski and Dominika Wokolorczyk and Rachel Hart and Wayne Glover and Jimmy Lam and Louise Taylor and Monica Salinas and Lidia Feliubadal{\'o} and Rogier Oldenburg and Ruben Cremers and Gerald Verhaegh and {van Zelst-Stams}, {Wendy A.} and Oosterwijk, {Jan C.} and Jackie Cook and Rosario, {Derek J.} and Buys, {Saundra S.} and Tom Conner and Susan Domchek and Jacquelyn Powers and Ausems, {Margreet Gem} and Teixeira, {Manuel R.} and Sofia Maia and Louise Izatt and Rita Schmutzler and Kerstin Rhiem and Foulkes, {William D.} and Talia Boshari and Rosemarie Davidson and Marielle Ruijs and {Helderman-van den Enden}, {Apollonia Tjm} and Lesley Andrews and Lisa Walker and Katie Snape and Alex Henderson and Irene Jobson and Lindeman, {Geoffrey J.} and Annelie Liljegren and Marion Harris and Adank, {Muriel A.} and Judy Kirk and Amy Taylor and Rachel Susman and Rakefet Chen-Shtoyerman and Nicholas Pachter and Allan Spigelman and Lucy Side and Janez Zgajnar and Josefina Mora and Carole Brewer and Neus Gadea and Brady, {Angela F.} and David Gallagher and {van Os}, Theo and Alan Donaldson and Vigdis Stefansdottir and Julian Barwell and James, {Paul A.} and Declan Murphy and Eitan Friedman and Nicola Nicolai and Lynn Greenhalgh and Elias Obeid and Vedang Murthy and Lucia Copakova and John McGrath and Soo-Hwang Teo and Sara Strom and Karin Kast and Leongamornlert, {Daniel A.} and Anthony Chamberlain and Jenny Pope and Newlin, {Anna C.} and Neil Aaronson and Audrey Ardern-Jones and Chris Bangma and Elena Castro and David Dearnaley and Jorunn Eyfjord and Alison Falconer and Foster, {Christopher S.} and Henrik Gronberg and Hamdy, {Freddie C.} and Oskar Johannsson and Vincent Khoo and Jan Lubinski and Grindedal, {Eli Marie} and Joanne McKinley and Kylie Shackleton and Mitra, {Anita V.} and Clare Moynihan and Gad Rennert and Mohnish Suri and Karen Tricker and Sue Moss and Zsofia Kote-Jarai and Andrew Vickers and Hans Lilja and Helfand, {Brian T.} and Eeles, {Rosalind A.}",
year = "2018",
doi = "10.1038/bjc.2017.429",
language = "English",
volume = "118",
pages = "266--276",
journal = "British Journal of Cancer",
issn = "0007-0920",
publisher = "Nature Publishing Group",
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Mikropoulos, C, Selkirk, CGH, Saya, S, Bancroft, E, Vertosick, E, Dadaev, T, Brendler, C, Page, E, Dias, A, Evans, DG, Rothwell, J, Maehle, L, Axcrona, K, Richardson, K, Eccles, D, Jensen, T, Osther, PJ, van Asperen, CJ, Vasen, H, Kiemeney, LA, Ringelberg, J, Cybulski, C, Wokolorczyk, D, Hart, R, Glover, W, Lam, J, Taylor, L, Salinas, M, Feliubadaló, L, Oldenburg, R, Cremers, R, Verhaegh, G, van Zelst-Stams, WA, Oosterwijk, JC, Cook, J, Rosario, DJ, Buys, SS, Conner, T, Domchek, S, Powers, J, Ausems, MG, Teixeira, MR, Maia, S, Izatt, L, Schmutzler, R, Rhiem, K, Foulkes, WD, Boshari, T, Davidson, R, Ruijs, M, Helderman-van den Enden, AT, Andrews, L, Walker, L, Snape, K, Henderson, A, Jobson, I, Lindeman, GJ, Liljegren, A, Harris, M, Adank, MA, Kirk, J, Taylor, A, Susman, R, Chen-Shtoyerman, R, Pachter, N, Spigelman, A, Side, L, Zgajnar, J, Mora, J, Brewer, C, Gadea, N, Brady, AF, Gallagher, D, van Os, T, Donaldson, A, Stefansdottir, V, Barwell, J, James, PA, Murphy, D, Friedman, E, Nicolai, N, Greenhalgh, L, Obeid, E, Murthy, V, Copakova, L, McGrath, J, Teo, S-H, Strom, S, Kast, K, Leongamornlert, DA, Chamberlain, A, Pope, J, Newlin, AC, Aaronson, N, Ardern-Jones, A, Bangma, C, Castro, E, Dearnaley, D, Eyfjord, J, Falconer, A, Foster, CS, Gronberg, H, Hamdy, FC, Johannsson, O, Khoo, V, Lubinski, J, Grindedal, EM, McKinley, J, Shackleton, K, Mitra, AV, Moynihan, C, Rennert, G, Suri, M, Tricker, K, Moss, S, Kote-Jarai, Z, Vickers, A, Lilja, H, Helfand, BT & Eeles, RA 2018, 'Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition' British Journal of Cancer, vol. 118, no. 2, pp. 266-276. https://doi.org/10.1038/bjc.2017.429

Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition. / Mikropoulos, Christos; Selkirk, Christina G. Hutten; Saya, Sibel; Bancroft, Elizabeth; Vertosick, Emily; Dadaev, Tokhir; Brendler, Charles; Page, Elizabeth; Dias, Alexander; Evans, D. Gareth; Rothwell, Jeanette; Maehle, Lovise; Axcrona, Karol; Richardson, Kate; Eccles, Diana; Jensen, Thomas; Osther, Palle J.; van Asperen, Christi J.; Vasen, Hans; Kiemeney, Lambertus A.; Ringelberg, Janneke; Cybulski, Cezary; Wokolorczyk, Dominika; Hart, Rachel; Glover, Wayne; Lam, Jimmy; Taylor, Louise; Salinas, Monica; Feliubadaló, Lidia; Oldenburg, Rogier; Cremers, Ruben; Verhaegh, Gerald; van Zelst-Stams, Wendy A.; Oosterwijk, Jan C.; Cook, Jackie; Rosario, Derek J.; Buys, Saundra S.; Conner, Tom; Domchek, Susan; Powers, Jacquelyn; Ausems, Margreet Gem; Teixeira, Manuel R.; Maia, Sofia; Izatt, Louise; Schmutzler, Rita; Rhiem, Kerstin; Foulkes, William D.; Boshari, Talia; Davidson, Rosemarie; Ruijs, Marielle; Helderman-van den Enden, Apollonia Tjm; Andrews, Lesley; Walker, Lisa; Snape, Katie; Henderson, Alex; Jobson, Irene; Lindeman, Geoffrey J.; Liljegren, Annelie; Harris, Marion; Adank, Muriel A.; Kirk, Judy; Taylor, Amy; Susman, Rachel; Chen-Shtoyerman, Rakefet; Pachter, Nicholas; Spigelman, Allan; Side, Lucy; Zgajnar, Janez; Mora, Josefina; Brewer, Carole; Gadea, Neus; Brady, Angela F.; Gallagher, David; van Os, Theo; Donaldson, Alan; Stefansdottir, Vigdis; Barwell, Julian; James, Paul A.; Murphy, Declan; Friedman, Eitan; Nicolai, Nicola; Greenhalgh, Lynn; Obeid, Elias; Murthy, Vedang; Copakova, Lucia; McGrath, John; Teo, Soo-Hwang; Strom, Sara; Kast, Karin; Leongamornlert, Daniel A.; Chamberlain, Anthony; Pope, Jenny; Newlin, Anna C.; Aaronson, Neil; Ardern-Jones, Audrey; Bangma, Chris; Castro, Elena; Dearnaley, David; Eyfjord, Jorunn; Falconer, Alison; Foster, Christopher S.; Gronberg, Henrik; Hamdy, Freddie C.; Johannsson, Oskar; Khoo, Vincent; Lubinski, Jan; Grindedal, Eli Marie; McKinley, Joanne; Shackleton, Kylie; Mitra, Anita V.; Moynihan, Clare; Rennert, Gad; Suri, Mohnish; Tricker, Karen; Moss, Sue; Kote-Jarai, Zsofia; Vickers, Andrew; Lilja, Hans; Helfand, Brian T.; Eeles, Rosalind A.

In: British Journal of Cancer, Vol. 118, No. 2, 2018, p. 266-276.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition

AU - Mikropoulos, Christos

AU - Selkirk, Christina G. Hutten

AU - Saya, Sibel

AU - Bancroft, Elizabeth

AU - Vertosick, Emily

AU - Dadaev, Tokhir

AU - Brendler, Charles

AU - Page, Elizabeth

AU - Dias, Alexander

AU - Evans, D. Gareth

AU - Rothwell, Jeanette

AU - Maehle, Lovise

AU - Axcrona, Karol

AU - Richardson, Kate

AU - Eccles, Diana

AU - Jensen, Thomas

AU - Osther, Palle J.

AU - van Asperen, Christi J.

AU - Vasen, Hans

AU - Kiemeney, Lambertus A.

AU - Ringelberg, Janneke

AU - Cybulski, Cezary

AU - Wokolorczyk, Dominika

AU - Hart, Rachel

AU - Glover, Wayne

AU - Lam, Jimmy

AU - Taylor, Louise

AU - Salinas, Monica

AU - Feliubadaló, Lidia

AU - Oldenburg, Rogier

AU - Cremers, Ruben

AU - Verhaegh, Gerald

AU - van Zelst-Stams, Wendy A.

AU - Oosterwijk, Jan C.

AU - Cook, Jackie

AU - Rosario, Derek J.

AU - Buys, Saundra S.

AU - Conner, Tom

AU - Domchek, Susan

AU - Powers, Jacquelyn

AU - Ausems, Margreet Gem

AU - Teixeira, Manuel R.

AU - Maia, Sofia

AU - Izatt, Louise

AU - Schmutzler, Rita

AU - Rhiem, Kerstin

AU - Foulkes, William D.

AU - Boshari, Talia

AU - Davidson, Rosemarie

AU - Ruijs, Marielle

AU - Helderman-van den Enden, Apollonia Tjm

AU - Andrews, Lesley

AU - Walker, Lisa

AU - Snape, Katie

AU - Henderson, Alex

AU - Jobson, Irene

AU - Lindeman, Geoffrey J.

AU - Liljegren, Annelie

AU - Harris, Marion

AU - Adank, Muriel A.

AU - Kirk, Judy

AU - Taylor, Amy

AU - Susman, Rachel

AU - Chen-Shtoyerman, Rakefet

AU - Pachter, Nicholas

AU - Spigelman, Allan

AU - Side, Lucy

AU - Zgajnar, Janez

AU - Mora, Josefina

AU - Brewer, Carole

AU - Gadea, Neus

AU - Brady, Angela F.

AU - Gallagher, David

AU - van Os, Theo

AU - Donaldson, Alan

AU - Stefansdottir, Vigdis

AU - Barwell, Julian

AU - James, Paul A.

AU - Murphy, Declan

AU - Friedman, Eitan

AU - Nicolai, Nicola

AU - Greenhalgh, Lynn

AU - Obeid, Elias

AU - Murthy, Vedang

AU - Copakova, Lucia

AU - McGrath, John

AU - Teo, Soo-Hwang

AU - Strom, Sara

AU - Kast, Karin

AU - Leongamornlert, Daniel A.

AU - Chamberlain, Anthony

AU - Pope, Jenny

AU - Newlin, Anna C.

AU - Aaronson, Neil

AU - Ardern-Jones, Audrey

AU - Bangma, Chris

AU - Castro, Elena

AU - Dearnaley, David

AU - Eyfjord, Jorunn

AU - Falconer, Alison

AU - Foster, Christopher S.

AU - Gronberg, Henrik

AU - Hamdy, Freddie C.

AU - Johannsson, Oskar

AU - Khoo, Vincent

AU - Lubinski, Jan

AU - Grindedal, Eli Marie

AU - McKinley, Joanne

AU - Shackleton, Kylie

AU - Mitra, Anita V.

AU - Moynihan, Clare

AU - Rennert, Gad

AU - Suri, Mohnish

AU - Tricker, Karen

AU - Moss, Sue

AU - Kote-Jarai, Zsofia

AU - Vickers, Andrew

AU - Lilja, Hans

AU - Helfand, Brian T.

AU - Eeles, Rosalind A.

PY - 2018

Y1 - 2018

N2 - Background:Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition to PrCa due to BRCA1/2 mutations. This analysis evaluates the utility of PSA and PSAV for identifying PrCa and high-grade disease in this cohort.Methods:PSAV was calculated using logistic regression to determine if PSA or PSAV predicted the result of prostate biopsy (PB) in men with elevated PSA values. Cox regression was used to determine whether PSA or PSAV predicted PSA elevation in men with low PSAs. Interaction terms were included in the models to determine whether BRCA status influenced the predictiveness of PSA or PSAV.Results:1634 participants had 3/43 PSA readings of whom 174 underwent PB and 45 PrCas diagnosed. In men with PSA >3.0 ng ml -l, PSAV was not significantly associated with presence of cancer or high-grade disease. PSAV did not add to PSA for predicting time to an elevated PSA. When comparing BRCA1/2 carriers to non-carriers, we found a significant interaction between BRCA status and last PSA before biopsy (P=0.031) and BRCA2 status and PSAV (P=0.024). However, PSAV was not predictive of biopsy outcome in BRCA2 carriers.Conclusions:PSA is more strongly predictive of PrCa in BRCA carriers than non-carriers. We did not find evidence that PSAV aids decision-making for BRCA carriers over absolute PSA value alone.

AB - Background:Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition to PrCa due to BRCA1/2 mutations. This analysis evaluates the utility of PSA and PSAV for identifying PrCa and high-grade disease in this cohort.Methods:PSAV was calculated using logistic regression to determine if PSA or PSAV predicted the result of prostate biopsy (PB) in men with elevated PSA values. Cox regression was used to determine whether PSA or PSAV predicted PSA elevation in men with low PSAs. Interaction terms were included in the models to determine whether BRCA status influenced the predictiveness of PSA or PSAV.Results:1634 participants had 3/43 PSA readings of whom 174 underwent PB and 45 PrCas diagnosed. In men with PSA >3.0 ng ml -l, PSAV was not significantly associated with presence of cancer or high-grade disease. PSAV did not add to PSA for predicting time to an elevated PSA. When comparing BRCA1/2 carriers to non-carriers, we found a significant interaction between BRCA status and last PSA before biopsy (P=0.031) and BRCA2 status and PSAV (P=0.024). However, PSAV was not predictive of biopsy outcome in BRCA2 carriers.Conclusions:PSA is more strongly predictive of PrCa in BRCA carriers than non-carriers. We did not find evidence that PSAV aids decision-making for BRCA carriers over absolute PSA value alone.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85041064923&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/29301143

U2 - 10.1038/bjc.2017.429

DO - 10.1038/bjc.2017.429

M3 - Article

VL - 118

SP - 266

EP - 276

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 0007-0920

IS - 2

ER -