Psychiatric perspective

Richard van Dyck, Anton J. L. M. van Balkom, Odile A. van den Heuvel, Christel M. Middeldorp

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review


This chapter argues that real progress in the management of anxiety disorders will depend on a further understanding of etiological processes. It focuses mainly on biological and psychopharmacological aspects of anxiety research. In order to make further advances, a major effort to clarify etiology of anxiety disorders is needed. Since 2006 it has been possible to perform genome-wide association (GWA) studies, in which single nucleotide polymorphisms (SNPs) are genotyped across the whole genome of an individual and subsequently associated to a disorder. GWA studies have changed the view on how genetic factors influence complex traits, such as psychiatric disorders. The field of anxiety disorders research will gain from better translation from clinical phenotype (early signs, symptom differentiation, comorbidity, and end-stage profiles) and treatment response profiles to biomarkers derived from genetic and brain imaging research, and vice versa. A multidisciplinary approach will be the most fruitful.
Original languageEnglish
Title of host publicationThe Wiley Handbook of Anxiety Disorders
ISBN (Electronic)9781118775349
ISBN (Print)9781118775356
Publication statusPublished - 1 Jan 2014

Publication series

NameThe Wiley Handbook of Anxiety Disorders

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