Psychiatrische beelden bij afwijkende cortisolproductie: Een vaak laat gestelde diagnose

Translated title of the contribution: Psychiatric manifestations due to abnormal glucocorticoid levels

Kinke M. Lommerse*, Francis M. Dijkstra, A. J.P. Boeke, E. M.W. Eekhoff, Gabriel E. Jacobs

*Corresponding author for this work

Research output: Contribution to journalArticleProfessional


This clinical case presentation describes the disease trajectory in two patients who presented with psychiatric symptoms as a result of abnormal serum glucocorticoid levels. One case involves a 58-year-old man with hypercortisolism, the other case concerns a 55-year-old woman with hypocortisolism. In both cases there was a considerable diagnostic delay in recognizing the underlying adrenal gland pathology. Abnormal glucocorticoid levels, caused by endocrine disorders, often results in psychiatric symptoms. Delay in diagnosis may have adverse consequences. Hyper- or hypocortisolism should be considered in patients who present with an atypical presentation of psychiatric symptoms. Moreover, the absence of specific physical signs or symptoms at first presentation in such patients does not exclude an underlying endocrinological cause. Therefore, physical and psychiatric reassessment of such patients should be considered at regular intervals.

Translated title of the contributionPsychiatric manifestations due to abnormal glucocorticoid levels
Original languageDutch
Article numberD89p
JournalNederlands Tijdschrift voor Geneeskunde
Issue number40
Publication statusPublished - 2016

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