TY - JOUR
T1 - Psychosocial factors and cancer incidence (PSY-CA): Protocol for individual participant data meta-analyses
AU - van Tuijl, Lonneke A.
AU - Voogd, Adri C.
AU - de Graeff, Alexander
AU - Hoogendoorn, Adriaan W.
AU - Ranchor, Adelita V.
AU - Pan, Kuan-Yu
AU - Basten, Maartje
AU - Lamers, Femke
AU - Geerlings, Mirjam I.
AU - Abell, Jessica G.
AU - Awadalla, Philip
AU - Bakker, Marije F.
AU - Beekman, Aartjan T. F.
AU - Bjerkeset, Ottar
AU - Boyd, Andy
AU - Cui, Yunsong
AU - Galenkamp, Henrike
AU - Garssen, Bert
AU - Hellingman, Sean
AU - Huisman, Martijn
AU - Huss, Anke
AU - Keats, Melanie R.
AU - Kok, Almar A. L.
AU - Luik, Annemarie I.
AU - Noisel, Nolwenn
AU - Onland-Moret, N. Charlotte
AU - Payette, Yves
AU - Penninx, Brenda W. J. H.
AU - Portengen, L. tzen
AU - Rissanen, Ina
AU - Roest, Annelieke M.
AU - Rosmalen, Judith G. M.
AU - Ruiter, Rikje
AU - Schoevers, Robert A.
AU - Soave, David M.
AU - Spaan, Mandy
AU - Steptoe, Andrew
AU - Stronks, Karien
AU - Sund, Erik R.
AU - Sweeney, Ellen
AU - Teyhan, Alison
AU - Vaartjes, Ilonca
AU - van der Willik, Kimberly D.
AU - van Leeuwen, Flora E.
AU - van Petersen, Rutger
AU - Verschuren, W. M. Monique
AU - Visseren, Frank
AU - Vermeulen, Roel
AU - Dekker, Joost
N1 - Funding Information:
The PSY‐CA consortium is supported by funding from the Dutch Cancer Society(VU2017‐8288).
Publisher Copyright:
© 2021 The Authors. Brain and Behavior published by Wiley Periodicals LLC
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/10
Y1 - 2021/10
N2 - Objectives: Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer. Methods: The psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology. Using data collected in 18 cohorts (N = 617,355), a preplanned two-stage individual participant data (IPD) meta-analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta-analyses will be performed on the risk estimates (stage 2). Conclusion: PSY-CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta-analyses.
AB - Objectives: Psychosocial factors have been hypothesized to increase the risk of cancer. This study aims (1) to test whether psychosocial factors (depression, anxiety, recent loss events, subjective social support, relationship status, general distress, and neuroticism) are associated with the incidence of any cancer (any, breast, lung, prostate, colorectal, smoking-related, and alcohol-related); (2) to test the interaction between psychosocial factors and factors related to cancer risk (smoking, alcohol use, weight, physical activity, sedentary behavior, sleep, age, sex, education, hormone replacement therapy, and menopausal status) with regard to the incidence of cancer; and (3) to test the mediating role of health behaviors (smoking, alcohol use, weight, physical activity, sedentary behavior, and sleep) in the relationship between psychosocial factors and the incidence of cancer. Methods: The psychosocial factors and cancer incidence (PSY-CA) consortium was established involving experts in the field of (psycho-)oncology, methodology, and epidemiology. Using data collected in 18 cohorts (N = 617,355), a preplanned two-stage individual participant data (IPD) meta-analysis is proposed. Standardized analyses will be conducted on harmonized datasets for each cohort (stage 1), and meta-analyses will be performed on the risk estimates (stage 2). Conclusion: PSY-CA aims to elucidate the relationship between psychosocial factors and cancer risk by addressing several shortcomings of prior meta-analyses.
KW - cancer risk
KW - depression
KW - health behaviors
KW - meta-analysis
KW - psycho-oncology
UR - http://www.scopus.com/inward/record.url?scp=85114316211&partnerID=8YFLogxK
U2 - 10.1002/brb3.2340
DO - 10.1002/brb3.2340
M3 - Article
C2 - 34473425
VL - 11
JO - Brain and Behavior
JF - Brain and Behavior
SN - 2162-3279
IS - 10
M1 - e2340
ER -