Quadriceps muscle endurance in patients with chronic obstructive pulmonary disease

Alex Van't Hul*, Jaap Harlaar, Rik Gosselink, Peter Hollander, Piet Postmus, Gert Kwakkel

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


The purpose of this study was to compare quadriceps muscle strength (maximal voluntary contraction, MVC), endurance (TLIM), and dynamic work capacity (WLIM) in 89 patients (57 men and 32 women) with chronic obstructive pulmonary disease (COPD) to 31 healthy controls (20 men and 11 women). Compared with the healthy subjects, COPD patients demonstrated statistically significant (P < 0.05) lower values for MVC, TLIM and WLIM. The MVC was 20-30% lower, whereas TLIM and WLIM were 70-80% lower in the patients. Stepwise multiple regression analysis revealed that pulmonary function variables contributed only partially to the explanation of variance in MVC, TLIM, and WLIM. Our results indicate that in patients with COPD, quadriceps muscle endurance and dynamic work capacity are impaired to a greater extent than is quadriceps muscle strength. For rehabilitation purposes, the findings may lead to more specific exercise programs, further enhancing rehabilitation outcomes in terms of functional abilities and social participation.

Original languageEnglish
Pages (from-to)267-274
Number of pages8
JournalMuscle and Nerve
Issue number2
Publication statusPublished - 1 Feb 2004

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