Quantification of bone involvement in Gaucher disease: MR imaging bone marrow burden score as an alternative to Dixon quantitative chemical shift MR imaging--initial experience

Mario Maas, Cornelis van Kuijk, Jaap Stoker, Carla E. M. Hollak, Erik M Akkerman, Johannes F M G Aerts, Gerard J den Heeten

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

PURPOSE: To develop a semiquantitative magnetic resonance (MR) imaging bone marrow burden (BMB) score with inclusion of both axial and peripheral bone marrow in Gaucher disease as an alternative to MR imaging with the Dixon quantitative chemical shift imaging (QCSI) technique.

MATERIALS AND METHODS: Two experienced musculoskeletal radiologists with no experience in evaluating Gaucher disease blindly analyzed MR images of lumbar spines and femora. Interobserver and intraobserver variability were tested. In addition, the BMB score was determined as a parameter to evaluate bone marrow response to enzyme supplementation therapy. Finally, the BMB score was compared with fat fraction measurements obtained with Dixon QCSI. Differences between groups were analyzed by using the nonparametric Mann-Whitney test. A P value of less than.05 was considered to represent significance. Correlation was calculated by using two-tailed nonparametric rank correlation (Spearman rho).

RESULTS: In 30 patients (mean age, 39.3 years; age range, 12-71 years) the mean fat fraction was 0.20 (range, 0.08-0.40). The BMB score range was 3-13 points. A significant correlation was found between the two observers when using BMB (rho = 0.91, P <.001). The intraobserver variation showed a significant correlation (rho = 0.99, P <.001). There was a significant correlation between BMB and QCSI (rho = -0.78, P <.001). Although BMB was less sensitive than Dixon QCSI, it showed enough sensitivity to allow detection of bone marrow response to enzyme supplementation therapy.

CONCLUSION: BMB is a reproducible semiquantitative scoring system that is easy to use. It combines MR imaging of both axial and peripheral bone marrow and shows a significant correlation with QCSI.

Original languageEnglish
Pages (from-to)554-61
Number of pages8
JournalRadiology
Volume229
Issue number2
DOIs
Publication statusPublished - Nov 2003

Cite this

Maas, Mario ; van Kuijk, Cornelis ; Stoker, Jaap ; Hollak, Carla E. M. ; Akkerman, Erik M ; Aerts, Johannes F M G ; den Heeten, Gerard J. / Quantification of bone involvement in Gaucher disease : MR imaging bone marrow burden score as an alternative to Dixon quantitative chemical shift MR imaging--initial experience. In: Radiology. 2003 ; Vol. 229, No. 2. pp. 554-61.
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title = "Quantification of bone involvement in Gaucher disease: MR imaging bone marrow burden score as an alternative to Dixon quantitative chemical shift MR imaging--initial experience",
abstract = "PURPOSE: To develop a semiquantitative magnetic resonance (MR) imaging bone marrow burden (BMB) score with inclusion of both axial and peripheral bone marrow in Gaucher disease as an alternative to MR imaging with the Dixon quantitative chemical shift imaging (QCSI) technique.MATERIALS AND METHODS: Two experienced musculoskeletal radiologists with no experience in evaluating Gaucher disease blindly analyzed MR images of lumbar spines and femora. Interobserver and intraobserver variability were tested. In addition, the BMB score was determined as a parameter to evaluate bone marrow response to enzyme supplementation therapy. Finally, the BMB score was compared with fat fraction measurements obtained with Dixon QCSI. Differences between groups were analyzed by using the nonparametric Mann-Whitney test. A P value of less than.05 was considered to represent significance. Correlation was calculated by using two-tailed nonparametric rank correlation (Spearman rho).RESULTS: In 30 patients (mean age, 39.3 years; age range, 12-71 years) the mean fat fraction was 0.20 (range, 0.08-0.40). The BMB score range was 3-13 points. A significant correlation was found between the two observers when using BMB (rho = 0.91, P <.001). The intraobserver variation showed a significant correlation (rho = 0.99, P <.001). There was a significant correlation between BMB and QCSI (rho = -0.78, P <.001). Although BMB was less sensitive than Dixon QCSI, it showed enough sensitivity to allow detection of bone marrow response to enzyme supplementation therapy.CONCLUSION: BMB is a reproducible semiquantitative scoring system that is easy to use. It combines MR imaging of both axial and peripheral bone marrow and shows a significant correlation with QCSI.",
keywords = "Adolescent, Adult, Aged, Bone Marrow, Bone Marrow Diseases, Child, Female, Femur, Gaucher Disease, Humans, Lumbar Vertebrae, Magnetic Resonance Imaging, Male, Middle Aged, Observer Variation, Reproducibility of Results, Journal Article",
author = "Mario Maas and {van Kuijk}, Cornelis and Jaap Stoker and Hollak, {Carla E. M.} and Akkerman, {Erik M} and Aerts, {Johannes F M G} and {den Heeten}, {Gerard J}",
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Quantification of bone involvement in Gaucher disease : MR imaging bone marrow burden score as an alternative to Dixon quantitative chemical shift MR imaging--initial experience. / Maas, Mario; van Kuijk, Cornelis; Stoker, Jaap; Hollak, Carla E. M.; Akkerman, Erik M; Aerts, Johannes F M G; den Heeten, Gerard J.

In: Radiology, Vol. 229, No. 2, 11.2003, p. 554-61.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Quantification of bone involvement in Gaucher disease

T2 - MR imaging bone marrow burden score as an alternative to Dixon quantitative chemical shift MR imaging--initial experience

AU - Maas, Mario

AU - van Kuijk, Cornelis

AU - Stoker, Jaap

AU - Hollak, Carla E. M.

AU - Akkerman, Erik M

AU - Aerts, Johannes F M G

AU - den Heeten, Gerard J

N1 - Copyright RSNA, 2003

PY - 2003/11

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N2 - PURPOSE: To develop a semiquantitative magnetic resonance (MR) imaging bone marrow burden (BMB) score with inclusion of both axial and peripheral bone marrow in Gaucher disease as an alternative to MR imaging with the Dixon quantitative chemical shift imaging (QCSI) technique.MATERIALS AND METHODS: Two experienced musculoskeletal radiologists with no experience in evaluating Gaucher disease blindly analyzed MR images of lumbar spines and femora. Interobserver and intraobserver variability were tested. In addition, the BMB score was determined as a parameter to evaluate bone marrow response to enzyme supplementation therapy. Finally, the BMB score was compared with fat fraction measurements obtained with Dixon QCSI. Differences between groups were analyzed by using the nonparametric Mann-Whitney test. A P value of less than.05 was considered to represent significance. Correlation was calculated by using two-tailed nonparametric rank correlation (Spearman rho).RESULTS: In 30 patients (mean age, 39.3 years; age range, 12-71 years) the mean fat fraction was 0.20 (range, 0.08-0.40). The BMB score range was 3-13 points. A significant correlation was found between the two observers when using BMB (rho = 0.91, P <.001). The intraobserver variation showed a significant correlation (rho = 0.99, P <.001). There was a significant correlation between BMB and QCSI (rho = -0.78, P <.001). Although BMB was less sensitive than Dixon QCSI, it showed enough sensitivity to allow detection of bone marrow response to enzyme supplementation therapy.CONCLUSION: BMB is a reproducible semiquantitative scoring system that is easy to use. It combines MR imaging of both axial and peripheral bone marrow and shows a significant correlation with QCSI.

AB - PURPOSE: To develop a semiquantitative magnetic resonance (MR) imaging bone marrow burden (BMB) score with inclusion of both axial and peripheral bone marrow in Gaucher disease as an alternative to MR imaging with the Dixon quantitative chemical shift imaging (QCSI) technique.MATERIALS AND METHODS: Two experienced musculoskeletal radiologists with no experience in evaluating Gaucher disease blindly analyzed MR images of lumbar spines and femora. Interobserver and intraobserver variability were tested. In addition, the BMB score was determined as a parameter to evaluate bone marrow response to enzyme supplementation therapy. Finally, the BMB score was compared with fat fraction measurements obtained with Dixon QCSI. Differences between groups were analyzed by using the nonparametric Mann-Whitney test. A P value of less than.05 was considered to represent significance. Correlation was calculated by using two-tailed nonparametric rank correlation (Spearman rho).RESULTS: In 30 patients (mean age, 39.3 years; age range, 12-71 years) the mean fat fraction was 0.20 (range, 0.08-0.40). The BMB score range was 3-13 points. A significant correlation was found between the two observers when using BMB (rho = 0.91, P <.001). The intraobserver variation showed a significant correlation (rho = 0.99, P <.001). There was a significant correlation between BMB and QCSI (rho = -0.78, P <.001). Although BMB was less sensitive than Dixon QCSI, it showed enough sensitivity to allow detection of bone marrow response to enzyme supplementation therapy.CONCLUSION: BMB is a reproducible semiquantitative scoring system that is easy to use. It combines MR imaging of both axial and peripheral bone marrow and shows a significant correlation with QCSI.

KW - Adolescent

KW - Adult

KW - Aged

KW - Bone Marrow

KW - Bone Marrow Diseases

KW - Child

KW - Female

KW - Femur

KW - Gaucher Disease

KW - Humans

KW - Lumbar Vertebrae

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Observer Variation

KW - Reproducibility of Results

KW - Journal Article

U2 - 10.1148/radiol.2292020296

DO - 10.1148/radiol.2292020296

M3 - Article

VL - 229

SP - 554

EP - 561

JO - Radiology Now

JF - Radiology Now

SN - 0033-8419

IS - 2

ER -