Abstract

Accumulation of amyloid beta can be visualized using [18F]florbetapir positron emission tomography. The aim of this study was to identify the optimal model for quantifying [18F]florbetapir uptake and to assess test–retest reliability of corresponding outcome measures. Eight Alzheimer’s disease patients (age: 67 ± 6 years, Mini-Mental State Examination (MMSE): 23 ± 3) and eight controls (age: 63 ± 4 years, MMSE: 30 ± 0) were included. Ninety-minute dynamic positron emission tomography scans, together with arterial blood sampling, were acquired immediately following a bolus injection of 294 ± 32 MBq [18F]florbetapir. Several plasma input models and the simplified reference tissue model (SRTM) were evaluated. The Akaike information criterion was used to identify the preferred kinetic model. Compared to controls, Alzheimer’s disease patients had lower MMSE scores and evidence for cortical Aβ pathology. A reversible two-tissue compartment model with fitted blood volume fraction (2T4k_VB) was the preferred mode...
Original languageEnglish
Pages (from-to)2172-2180
JournalJournal of Cerebral Blood Flow and Metabolism
Volume39
Issue number11
DOIs
Publication statusPublished - 1 Nov 2019

Cite this

@article{a5a02d9602ea4018999a7fa83308a6f8,
title = "Quantification of [ 18 F]florbetapir: A test–retest tracer kinetic modelling study",
abstract = "Accumulation of amyloid beta can be visualized using [18F]florbetapir positron emission tomography. The aim of this study was to identify the optimal model for quantifying [18F]florbetapir uptake and to assess test–retest reliability of corresponding outcome measures. Eight Alzheimer’s disease patients (age: 67 ± 6 years, Mini-Mental State Examination (MMSE): 23 ± 3) and eight controls (age: 63 ± 4 years, MMSE: 30 ± 0) were included. Ninety-minute dynamic positron emission tomography scans, together with arterial blood sampling, were acquired immediately following a bolus injection of 294 ± 32 MBq [18F]florbetapir. Several plasma input models and the simplified reference tissue model (SRTM) were evaluated. The Akaike information criterion was used to identify the preferred kinetic model. Compared to controls, Alzheimer’s disease patients had lower MMSE scores and evidence for cortical Aβ pathology. A reversible two-tissue compartment model with fitted blood volume fraction (2T4k_VB) was the preferred mode...",
keywords = "Alzheimer’s disease, Amyloid positron emission tomography, [18F]florbetapir, test–retest, tracer kinetic modelling",
author = "Golla, {Sandeep SV} and Verfaillie, {Sander CJ} and Ronald Boellaard and Adriaanse, {Sofie M} and Zwan, {Marissa D} and Schuit, {Robert C} and Tessa Timmers and Colin Groot and Patrick Schober and Philip Scheltens and {van der Flier}, {Wiesje M} and Windhorst, {Albert D} and {van Berckel}, {Bart NM} and Lammertsma, {Adriaan A}",
year = "2019",
month = "11",
day = "1",
doi = "10.1177/0271678X18783628",
language = "English",
volume = "39",
pages = "2172--2180",
journal = "Journal of Cerebral Blood Flow and Metabolism",
issn = "0271-678X",
publisher = "Nature Publishing Group",
number = "11",

}

TY - JOUR

T1 - Quantification of [ 18 F]florbetapir: A test–retest tracer kinetic modelling study

AU - Golla, Sandeep SV

AU - Verfaillie, Sander CJ

AU - Boellaard, Ronald

AU - Adriaanse, Sofie M

AU - Zwan, Marissa D

AU - Schuit, Robert C

AU - Timmers, Tessa

AU - Groot, Colin

AU - Schober, Patrick

AU - Scheltens, Philip

AU - van der Flier, Wiesje M

AU - Windhorst, Albert D

AU - van Berckel, Bart NM

AU - Lammertsma, Adriaan A

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Accumulation of amyloid beta can be visualized using [18F]florbetapir positron emission tomography. The aim of this study was to identify the optimal model for quantifying [18F]florbetapir uptake and to assess test–retest reliability of corresponding outcome measures. Eight Alzheimer’s disease patients (age: 67 ± 6 years, Mini-Mental State Examination (MMSE): 23 ± 3) and eight controls (age: 63 ± 4 years, MMSE: 30 ± 0) were included. Ninety-minute dynamic positron emission tomography scans, together with arterial blood sampling, were acquired immediately following a bolus injection of 294 ± 32 MBq [18F]florbetapir. Several plasma input models and the simplified reference tissue model (SRTM) were evaluated. The Akaike information criterion was used to identify the preferred kinetic model. Compared to controls, Alzheimer’s disease patients had lower MMSE scores and evidence for cortical Aβ pathology. A reversible two-tissue compartment model with fitted blood volume fraction (2T4k_VB) was the preferred mode...

AB - Accumulation of amyloid beta can be visualized using [18F]florbetapir positron emission tomography. The aim of this study was to identify the optimal model for quantifying [18F]florbetapir uptake and to assess test–retest reliability of corresponding outcome measures. Eight Alzheimer’s disease patients (age: 67 ± 6 years, Mini-Mental State Examination (MMSE): 23 ± 3) and eight controls (age: 63 ± 4 years, MMSE: 30 ± 0) were included. Ninety-minute dynamic positron emission tomography scans, together with arterial blood sampling, were acquired immediately following a bolus injection of 294 ± 32 MBq [18F]florbetapir. Several plasma input models and the simplified reference tissue model (SRTM) were evaluated. The Akaike information criterion was used to identify the preferred kinetic model. Compared to controls, Alzheimer’s disease patients had lower MMSE scores and evidence for cortical Aβ pathology. A reversible two-tissue compartment model with fitted blood volume fraction (2T4k_VB) was the preferred mode...

KW - Alzheimer’s disease

KW - Amyloid positron emission tomography

KW - [18F]florbetapir

KW - test–retest

KW - tracer kinetic modelling

UR - http://www.scopus.com/inward/record.url?scp=85049004477&partnerID=8YFLogxK

U2 - 10.1177/0271678X18783628

DO - 10.1177/0271678X18783628

M3 - Article

VL - 39

SP - 2172

EP - 2180

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

SN - 0271-678X

IS - 11

ER -