Quantitative 3D analysis of tissue damage in a rat model of microembolization

Theodosia Georgakopoulou; Anne-Eva van der Wijk; Erik N. T. P. Bakker; Ed vanBavel; Charles Majoie; Henk Marquering; Ed van Bavel; Alfons Hoekstra; Diederik Dippel; Hester Lingsma; Aad van der Lugt; Noor Samuels; Nikki Boodt; Yvo Roos; Simon de Meyer; Senna Staessens; Sarah Vandelanotte; Praneeta Konduri; Nerea Arrarte Terreros; Bastien Chopard; Franck Raynaud; Remy Petkantchin; Mikhail Panteleev; Alexey Shibeko; Karim Zouaoui Boudjeltia; Vanessa Blanc-Guillemaud; Francesco Migliavacca; Gabriele Dubini; Giulia Luraghi; Jose Felix Rodriguez Matas; Sara Bridio; Patrick Mc Garry; Michael Gilvarry; Ray McCarthy; Kevin Moerman; Behrooz Fereidoonnezhad; Anushree Dwivedi; Sharon Duffy; Stephen Payne; Tamas Jozsa; Sissy Georgakopoulou; Raymond Padmos; Victor Azizi; Claire Miller; Max van der Kolk

doi:10.1016/j.jbiomech.2021.110723

Quantitative 3D analysis of tissue damage in a rat model of microembolization

Theodosia Georgakopoulou, Anne-Eva van der Wijk, Erik N. T. P. Bakker, Ed vanBavel^*, Charles Majoie, Henk Marquering, Ed van Bavel, Alfons Hoekstra, Diederik Dippel, Hester Lingsma, Aad van der Lugt, Noor Samuels, Nikki Boodt, Yvo Roos, Simon de Meyer, Senna Staessens, Sarah Vandelanotte, Praneeta Konduri, Nerea Arrarte Terreros, Bastien ChopardFranck Raynaud, Remy Petkantchin, Mikhail Panteleev, Alexey Shibeko, Karim Zouaoui Boudjeltia, Vanessa Blanc-Guillemaud, Francesco Migliavacca, Gabriele Dubini, Giulia Luraghi, Jose Felix Rodriguez Matas, Sara Bridio, Patrick Mc Garry, Michael Gilvarry, Ray McCarthy, Kevin Moerman, Behrooz Fereidoonnezhad, Anushree Dwivedi, Sharon Duffy, Stephen Payne, Tamas Jozsa, Sissy Georgakopoulou, Raymond Padmos, Victor Azizi, Claire Miller, Max van der Kolk

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

There is a discrepancy between successful recanalization and good clinical outcome after endovascular treatment (EVT) in acute ischemic stroke patients. During removal of a thrombus, a shower of microemboli may release and lodge to the distal circulation. The objective of this study was to determine the extent of damage on brain tissue caused by microemboli. In a rat model of microembolization, a mixture of microsphere (MS) sizes (15, 25 and 50 µm diameter) was injected via the left internal carotid artery. A 3D image of the left hemisphere was reconstructed and a point-pattern spatial analysis was applied based on G- and K-functions to unravel the spatial correlation between MS and the induced hypoxia or infarction. We show a spatial correlation between MS and hypoxia or infarction spreading up to a distance of 1000–1500 µm. These results imply that microemboli, which individually may not always be harmful, can interact and result in local areas of hypoxia or even infarction when lodged in large numbers.

Original language	English
Article number	110723
Journal	Journal of Biomechanics
Volume	128
DOIs	https://doi.org/10.1016/j.jbiomech.2021.110723
Publication status	Published - 9 Nov 2021
Externally published	Yes

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10.1016/j.jbiomech.2021.110723

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Georgakopoulou, T., van der Wijk, A-E., Bakker, E. N. T. P., vanBavel, E., Majoie, C., Marquering, H., van Bavel, E., Hoekstra, A., Dippel, D., Lingsma, H., van der Lugt, A., Samuels, N., Boodt, N., Roos, Y., de Meyer, S., Staessens, S., Vandelanotte, S., Konduri, P., Terreros, N. A., ... van der Kolk, M. (2021). Quantitative 3D analysis of tissue damage in a rat model of microembolization. Journal of Biomechanics, 128, [110723]. https://doi.org/10.1016/j.jbiomech.2021.110723

@article{2e38ca19b0864604b07afae714b9ebf1,

title = "Quantitative 3D analysis of tissue damage in a rat model of microembolization",

abstract = "There is a discrepancy between successful recanalization and good clinical outcome after endovascular treatment (EVT) in acute ischemic stroke patients. During removal of a thrombus, a shower of microemboli may release and lodge to the distal circulation. The objective of this study was to determine the extent of damage on brain tissue caused by microemboli. In a rat model of microembolization, a mixture of microsphere (MS) sizes (15, 25 and 50 µm diameter) was injected via the left internal carotid artery. A 3D image of the left hemisphere was reconstructed and a point-pattern spatial analysis was applied based on G- and K-functions to unravel the spatial correlation between MS and the induced hypoxia or infarction. We show a spatial correlation between MS and hypoxia or infarction spreading up to a distance of 1000–1500 µm. These results imply that microemboli, which individually may not always be harmful, can interact and result in local areas of hypoxia or even infarction when lodged in large numbers.",

author = "Theodosia Georgakopoulou and {van der Wijk}, Anne-Eva and Bakker, {Erik N. T. P.} and Ed vanBavel and Charles Majoie and Henk Marquering and {van Bavel}, Ed and Alfons Hoekstra and Diederik Dippel and Hester Lingsma and {van der Lugt}, Aad and Noor Samuels and Nikki Boodt and Yvo Roos and {de Meyer}, Simon and Senna Staessens and Sarah Vandelanotte and Praneeta Konduri and Terreros, {Nerea Arrarte} and Bastien Chopard and Franck Raynaud and Remy Petkantchin and Mikhail Panteleev and Alexey Shibeko and Boudjeltia, {Karim Zouaoui} and Vanessa Blanc-Guillemaud and Francesco Migliavacca and Gabriele Dubini and Giulia Luraghi and Matas, {Jose Felix Rodriguez} and Sara Bridio and {Mc Garry}, Patrick and Michael Gilvarry and Ray McCarthy and Kevin Moerman and Behrooz Fereidoonnezhad and Anushree Dwivedi and Sharon Duffy and Stephen Payne and Tamas Jozsa and Sissy Georgakopoulou and Raymond Padmos and Victor Azizi and Claire Miller and {van der Kolk}, Max",

year = "2021",

month = nov,

day = "9",

doi = "10.1016/j.jbiomech.2021.110723",

language = "English",

volume = "128",

journal = "Journal of Biomechanics",

issn = "0021-9290",

publisher = "Elsevier Limited",

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Georgakopoulou, T, van der Wijk, A-E, Bakker, ENTP, vanBavel, E, Majoie, C, Marquering, H, van Bavel, E, Hoekstra, A, Dippel, D, Lingsma, H, van der Lugt, A, Samuels, N, Boodt, N, Roos, Y, de Meyer, S, Staessens, S, Vandelanotte, S, Konduri, P, Terreros, NA, Chopard, B, Raynaud, F, Petkantchin, R, Panteleev, M, Shibeko, A, Boudjeltia, KZ, Blanc-Guillemaud, V, Migliavacca, F, Dubini, G, Luraghi, G, Matas, JFR, Bridio, S, Mc Garry, P, Gilvarry, M, McCarthy, R, Moerman, K, Fereidoonnezhad, B, Dwivedi, A, Duffy, S, Payne, S, Jozsa, T, Georgakopoulou, S, Padmos, R, Azizi, V, Miller, C & van der Kolk, M 2021, 'Quantitative 3D analysis of tissue damage in a rat model of microembolization', Journal of Biomechanics, vol. 128, 110723. https://doi.org/10.1016/j.jbiomech.2021.110723

TY - JOUR

T1 - Quantitative 3D analysis of tissue damage in a rat model of microembolization

AU - Georgakopoulou, Theodosia

AU - van der Wijk, Anne-Eva

AU - Bakker, Erik N. T. P.

AU - vanBavel, Ed

AU - Majoie, Charles

AU - Marquering, Henk

AU - van Bavel, Ed

AU - Hoekstra, Alfons

AU - Dippel, Diederik

AU - Lingsma, Hester

AU - van der Lugt, Aad

AU - Samuels, Noor

AU - Boodt, Nikki

AU - Roos, Yvo

AU - de Meyer, Simon

AU - Staessens, Senna

AU - Vandelanotte, Sarah

AU - Konduri, Praneeta

AU - Terreros, Nerea Arrarte

AU - Chopard, Bastien

AU - Raynaud, Franck

AU - Petkantchin, Remy

AU - Panteleev, Mikhail

AU - Shibeko, Alexey

AU - Boudjeltia, Karim Zouaoui

AU - Blanc-Guillemaud, Vanessa

AU - Migliavacca, Francesco

AU - Dubini, Gabriele

AU - Luraghi, Giulia

AU - Matas, Jose Felix Rodriguez

AU - Bridio, Sara

AU - Mc Garry, Patrick

AU - Gilvarry, Michael

AU - McCarthy, Ray

AU - Moerman, Kevin

AU - Fereidoonnezhad, Behrooz

AU - Dwivedi, Anushree

AU - Duffy, Sharon

AU - Payne, Stephen

AU - Jozsa, Tamas

AU - Georgakopoulou, Sissy

AU - Padmos, Raymond

AU - Azizi, Victor

AU - Miller, Claire

AU - van der Kolk, Max

PY - 2021/11/9

Y1 - 2021/11/9

N2 - There is a discrepancy between successful recanalization and good clinical outcome after endovascular treatment (EVT) in acute ischemic stroke patients. During removal of a thrombus, a shower of microemboli may release and lodge to the distal circulation. The objective of this study was to determine the extent of damage on brain tissue caused by microemboli. In a rat model of microembolization, a mixture of microsphere (MS) sizes (15, 25 and 50 µm diameter) was injected via the left internal carotid artery. A 3D image of the left hemisphere was reconstructed and a point-pattern spatial analysis was applied based on G- and K-functions to unravel the spatial correlation between MS and the induced hypoxia or infarction. We show a spatial correlation between MS and hypoxia or infarction spreading up to a distance of 1000–1500 µm. These results imply that microemboli, which individually may not always be harmful, can interact and result in local areas of hypoxia or even infarction when lodged in large numbers.

AB - There is a discrepancy between successful recanalization and good clinical outcome after endovascular treatment (EVT) in acute ischemic stroke patients. During removal of a thrombus, a shower of microemboli may release and lodge to the distal circulation. The objective of this study was to determine the extent of damage on brain tissue caused by microemboli. In a rat model of microembolization, a mixture of microsphere (MS) sizes (15, 25 and 50 µm diameter) was injected via the left internal carotid artery. A 3D image of the left hemisphere was reconstructed and a point-pattern spatial analysis was applied based on G- and K-functions to unravel the spatial correlation between MS and the induced hypoxia or infarction. We show a spatial correlation between MS and hypoxia or infarction spreading up to a distance of 1000–1500 µm. These results imply that microemboli, which individually may not always be harmful, can interact and result in local areas of hypoxia or even infarction when lodged in large numbers.

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85114684544&origin=inward

UR - https://www.ncbi.nlm.nih.gov/pubmed/34509910

U2 - 10.1016/j.jbiomech.2021.110723

DO - 10.1016/j.jbiomech.2021.110723

M3 - Article

C2 - 34509910

SN - 0021-9290

VL - 128

JO - Journal of Biomechanics

JF - Journal of Biomechanics

M1 - 110723

ER -

Quantitative 3D analysis of tissue damage in a rat model of microembolization

Abstract

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