Quantitative experimental comparison of HRRT versus HR+ PET brain studies

F. H P Van Velden, Reina W. Kloet, H. W A M De Jong, Adriaan A. Lammertsma, Ronald Boellaard

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

Abstract

The High Resolution Research Tomograph (HRRT) is a dedicated 3D brain positron emission tomograph (PET), designed for a resolution of 3 mm or less. Recent improvements in image reconstruction strategies, such as the implementation of ordinary Poisson OSEM, improved the quantitative accuracy of HRRT PET. Further improvement of its accuracy might be expected using a new randoms estimation method based on coincidence histograms. The purpose of the present study was therefore to further evaluate the accuracy of HRRT studies using these new reconstruction methods. Moreover, data will be compared with those measured on a clinical HR+ PET scanner (Siemens), which has been used most frequently for human brain applications so far. To this end, a number of phantom experiment using e.g. NEMA scatter and attenuation, homogeneous (linearity and uniformity) and anthropomorphic brain phantoms, have been performed on both scanners. When using the new randoms estimation method, HRRT experiments showed a remnant scatter fraction < 5%, uniformity < 5% and linearity < 3% up to 136 MBq. These results were similar of better than those obtained with the HR+. HRRT brain phantom studies provided accurate results within 10 and 15% for grey and white matter areas, respectively, for high statistics (> 1800s) scans only. Large under- and overestimations of 20 and 50% in grey and white matter areas, respectively, were observed in case of short acquisition frames (10-30s). As short acquisition frames of 10-30s are normally applied in dynamic brain studies, it is concluded that further refinement of image reconstruction strategies [1] is required to obtain more accurate results, which are comparable with those of the HR+, for dynamic HRRT PET brain studies.

Original languageEnglish
Title of host publication2006 IEEE Nuclear Science Symposium - Conference Record
Pages3097-3099
Number of pages3
Volume5
DOIs
Publication statusPublished - 1 Dec 2007
Event2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD - San Diego, CA, United States
Duration: 29 Oct 20064 Nov 2006

Conference

Conference2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD
CountryUnited States
CitySan Diego, CA
Period29/10/200604/11/2006

Cite this

Van Velden, F. H. P., Kloet, R. W., De Jong, H. W. A. M., Lammertsma, A. A., & Boellaard, R. (2007). Quantitative experimental comparison of HRRT versus HR+ PET brain studies. In 2006 IEEE Nuclear Science Symposium - Conference Record (Vol. 5, pp. 3097-3099). [4179686] https://doi.org/10.1109/NSSMIC.2006.356529
Van Velden, F. H P ; Kloet, Reina W. ; De Jong, H. W A M ; Lammertsma, Adriaan A. ; Boellaard, Ronald. / Quantitative experimental comparison of HRRT versus HR+ PET brain studies. 2006 IEEE Nuclear Science Symposium - Conference Record. Vol. 5 2007. pp. 3097-3099
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abstract = "The High Resolution Research Tomograph (HRRT) is a dedicated 3D brain positron emission tomograph (PET), designed for a resolution of 3 mm or less. Recent improvements in image reconstruction strategies, such as the implementation of ordinary Poisson OSEM, improved the quantitative accuracy of HRRT PET. Further improvement of its accuracy might be expected using a new randoms estimation method based on coincidence histograms. The purpose of the present study was therefore to further evaluate the accuracy of HRRT studies using these new reconstruction methods. Moreover, data will be compared with those measured on a clinical HR+ PET scanner (Siemens), which has been used most frequently for human brain applications so far. To this end, a number of phantom experiment using e.g. NEMA scatter and attenuation, homogeneous (linearity and uniformity) and anthropomorphic brain phantoms, have been performed on both scanners. When using the new randoms estimation method, HRRT experiments showed a remnant scatter fraction < 5{\%}, uniformity < 5{\%} and linearity < 3{\%} up to 136 MBq. These results were similar of better than those obtained with the HR+. HRRT brain phantom studies provided accurate results within 10 and 15{\%} for grey and white matter areas, respectively, for high statistics (> 1800s) scans only. Large under- and overestimations of 20 and 50{\%} in grey and white matter areas, respectively, were observed in case of short acquisition frames (10-30s). As short acquisition frames of 10-30s are normally applied in dynamic brain studies, it is concluded that further refinement of image reconstruction strategies [1] is required to obtain more accurate results, which are comparable with those of the HR+, for dynamic HRRT PET brain studies.",
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Van Velden, FHP, Kloet, RW, De Jong, HWAM, Lammertsma, AA & Boellaard, R 2007, Quantitative experimental comparison of HRRT versus HR+ PET brain studies. in 2006 IEEE Nuclear Science Symposium - Conference Record. vol. 5, 4179686, pp. 3097-3099, 2006 IEEE Nuclear Science Symposium, Medical Imaging Conference and 15th International Workshop on Room-Temperature Semiconductor X- and Gamma-Ray Detectors, Special Focus Workshops, NSS/MIC/RTSD, San Diego, CA, United States, 29/10/2006. https://doi.org/10.1109/NSSMIC.2006.356529

Quantitative experimental comparison of HRRT versus HR+ PET brain studies. / Van Velden, F. H P; Kloet, Reina W.; De Jong, H. W A M; Lammertsma, Adriaan A.; Boellaard, Ronald.

2006 IEEE Nuclear Science Symposium - Conference Record. Vol. 5 2007. p. 3097-3099 4179686.

Research output: Chapter in Book/Report/Conference proceedingConference contributionAcademicpeer-review

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Van Velden FHP, Kloet RW, De Jong HWAM, Lammertsma AA, Boellaard R. Quantitative experimental comparison of HRRT versus HR+ PET brain studies. In 2006 IEEE Nuclear Science Symposium - Conference Record. Vol. 5. 2007. p. 3097-3099. 4179686 https://doi.org/10.1109/NSSMIC.2006.356529