Rab7a and Rab27b control secretion of endothelial microRNA through extracellular vesicles

Nicolas Jaé, David G. McEwan, Yosif Manavski, Reinier A. Boon, Stefanie Dimmeler*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

By transporting regulatory RNAs like microRNAs, extracellular vesicles provide a novel layer of intercellular gene regulation. However, the underlying secretory pathways and the mechanisms of cargo selection are poorly understood. Rab GTPases are central coordinators of membrane trafficking with distinct members of this family being responsible for specific transport pathways. Here we identified a vesicular export mechanism for miR-143, induced by the shear stress responsive transcription factor KLF2, and demonstrate its dependency on Rab7a/Rab27b in endothelial cells.

Original languageEnglish
Article number37350
Pages (from-to)3182-3188
Number of pages7
JournalFEBS Letters
Volume589
Issue number20
DOIs
Publication statusPublished - 7 Oct 2015

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