Radiation-induced lung toxicity - Cellular and molecular mechanisms of pathogenesis, management, and literature review

Lukas Käsmann*, Alexander Dietrich, Claudia A. Staab-Weijnitz, Farkhad Manapov, Jürgen Behr, Andreas Rimner, Branislav Jeremic, Suresh Senan, Dirk De Ruysscher, Kirsten Lauber, Claus Belka

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

Lung, breast, and esophageal cancer represent three common malignancies with high incidence and mortality worldwide. The management of these tumors critically relies on radiotherapy as a major part of multi-modality care, and treatment-related toxicities, such as radiation-induced pneumonitis and/or lung fibrosis, are important dose limiting factors with direct impact on patient outcomes and quality of life. In this review, we summarize the current understanding of radiation-induced pneumonitis and pulmonary fibrosis, present predictive factors as well as recent diagnostic and therapeutic advances. Novel candidates for molecularly targeted approaches to prevent and/or treat radiation-induced pneumonitis and pulmonary fibrosis are discussed.

Original languageEnglish
Article number214
JournalRadiation Oncology
Volume15
Issue number1
DOIs
Publication statusPublished - 10 Sep 2020

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