Radiotherapy following breast-conserving surgery: more local recurrences after longer delay

B J Slotman, O W Meyer, K H Njo, A B Karim

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

OBJECTIVE: Evaluation of results of breast conserving therapy in early stage breast cancer and of importance of time interval between surgery and radiotherapy.

DESIGN: Descriptive study.

LOCATION: Free University Hospital, Amsterdam.

METHOD: In the period 1980-1989, 554 patients with 560 invasive breast cancers were referred for radiotherapy after wide local excision of the tumour with axillary lymph node dissection. The dose to the breast was 50 Gy + 15 Gy boost dose. In case of positive margins, a higher boost dose (20-25 Gy) was given. Node-positive patients received adjuvant chemotherapy (premenopausal patients) or hormonal therapy (postmenopausal patients).

RESULTS: The median follow-up period was 82 months (range 52-160 months). The 5 and 10-year survival rates were 86.7% and 72.6%, respectively. Local (breast) relapse occurred in 22 patients (3.9%). The breast recurrence rate was 8/329 (2.4%) for patients who started radiotherapy within 7 weeks after surgery, as against 14/231 (6.1%) for patients with a longer interval (p < 0.05). In Cox's proportional hazards analysis, age (negative relation), T-stage and interval between surgery and radiotherapy were identified as independent factors predictive of breast recurrence (p < 0.05).

CONCLUSION: A delay of radiotherapy after breast conserving surgery of more than 7 weeks can adversely affect the local tumour control rate.

Translated title of the contributionRadiotherapy following breast-conserving surgery: more local recurrences after longer delay
Original languageDutch
Pages (from-to)2427-32
Number of pages6
JournalNederlands Tijdschrift voor Geneeskunde
Volume139
Issue number47
Publication statusPublished - 25 Nov 1995

Cite this

@article{fcd844d4921b4602a6a0c5a2703dad88,
title = "Radiotherapie na mammasparende operatie: na langer uitstel meer lokaal recidief",
abstract = "OBJECTIVE: Evaluation of results of breast conserving therapy in early stage breast cancer and of importance of time interval between surgery and radiotherapy.DESIGN: Descriptive study.LOCATION: Free University Hospital, Amsterdam.METHOD: In the period 1980-1989, 554 patients with 560 invasive breast cancers were referred for radiotherapy after wide local excision of the tumour with axillary lymph node dissection. The dose to the breast was 50 Gy + 15 Gy boost dose. In case of positive margins, a higher boost dose (20-25 Gy) was given. Node-positive patients received adjuvant chemotherapy (premenopausal patients) or hormonal therapy (postmenopausal patients).RESULTS: The median follow-up period was 82 months (range 52-160 months). The 5 and 10-year survival rates were 86.7{\%} and 72.6{\%}, respectively. Local (breast) relapse occurred in 22 patients (3.9{\%}). The breast recurrence rate was 8/329 (2.4{\%}) for patients who started radiotherapy within 7 weeks after surgery, as against 14/231 (6.1{\%}) for patients with a longer interval (p < 0.05). In Cox's proportional hazards analysis, age (negative relation), T-stage and interval between surgery and radiotherapy were identified as independent factors predictive of breast recurrence (p < 0.05).CONCLUSION: A delay of radiotherapy after breast conserving surgery of more than 7 weeks can adversely affect the local tumour control rate.",
keywords = "Adult, Aged, Aged, 80 and over, Breast Neoplasms/radiotherapy, Female, Follow-Up Studies, Humans, Lymph Node Excision, Mastectomy, Modified Radical, Middle Aged, Neoplasm Recurrence, Local/pathology, Postoperative Period, Radiotherapy Dosage, Time Factors",
author = "Slotman, {B J} and Meyer, {O W} and Njo, {K H} and Karim, {A B}",
year = "1995",
month = "11",
day = "25",
language = "Dutch",
volume = "139",
pages = "2427--32",
journal = "Nederlands Tijdschrift voor Geneeskunde",
issn = "0028-2162",
publisher = "Bohn Stafleu van Loghum",
number = "47",

}

Radiotherapie na mammasparende operatie : na langer uitstel meer lokaal recidief. / Slotman, B J; Meyer, O W; Njo, K H; Karim, A B.

In: Nederlands Tijdschrift voor Geneeskunde, Vol. 139, No. 47, 25.11.1995, p. 2427-32.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Radiotherapie na mammasparende operatie

T2 - na langer uitstel meer lokaal recidief

AU - Slotman, B J

AU - Meyer, O W

AU - Njo, K H

AU - Karim, A B

PY - 1995/11/25

Y1 - 1995/11/25

N2 - OBJECTIVE: Evaluation of results of breast conserving therapy in early stage breast cancer and of importance of time interval between surgery and radiotherapy.DESIGN: Descriptive study.LOCATION: Free University Hospital, Amsterdam.METHOD: In the period 1980-1989, 554 patients with 560 invasive breast cancers were referred for radiotherapy after wide local excision of the tumour with axillary lymph node dissection. The dose to the breast was 50 Gy + 15 Gy boost dose. In case of positive margins, a higher boost dose (20-25 Gy) was given. Node-positive patients received adjuvant chemotherapy (premenopausal patients) or hormonal therapy (postmenopausal patients).RESULTS: The median follow-up period was 82 months (range 52-160 months). The 5 and 10-year survival rates were 86.7% and 72.6%, respectively. Local (breast) relapse occurred in 22 patients (3.9%). The breast recurrence rate was 8/329 (2.4%) for patients who started radiotherapy within 7 weeks after surgery, as against 14/231 (6.1%) for patients with a longer interval (p < 0.05). In Cox's proportional hazards analysis, age (negative relation), T-stage and interval between surgery and radiotherapy were identified as independent factors predictive of breast recurrence (p < 0.05).CONCLUSION: A delay of radiotherapy after breast conserving surgery of more than 7 weeks can adversely affect the local tumour control rate.

AB - OBJECTIVE: Evaluation of results of breast conserving therapy in early stage breast cancer and of importance of time interval between surgery and radiotherapy.DESIGN: Descriptive study.LOCATION: Free University Hospital, Amsterdam.METHOD: In the period 1980-1989, 554 patients with 560 invasive breast cancers were referred for radiotherapy after wide local excision of the tumour with axillary lymph node dissection. The dose to the breast was 50 Gy + 15 Gy boost dose. In case of positive margins, a higher boost dose (20-25 Gy) was given. Node-positive patients received adjuvant chemotherapy (premenopausal patients) or hormonal therapy (postmenopausal patients).RESULTS: The median follow-up period was 82 months (range 52-160 months). The 5 and 10-year survival rates were 86.7% and 72.6%, respectively. Local (breast) relapse occurred in 22 patients (3.9%). The breast recurrence rate was 8/329 (2.4%) for patients who started radiotherapy within 7 weeks after surgery, as against 14/231 (6.1%) for patients with a longer interval (p < 0.05). In Cox's proportional hazards analysis, age (negative relation), T-stage and interval between surgery and radiotherapy were identified as independent factors predictive of breast recurrence (p < 0.05).CONCLUSION: A delay of radiotherapy after breast conserving surgery of more than 7 weeks can adversely affect the local tumour control rate.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Breast Neoplasms/radiotherapy

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Lymph Node Excision

KW - Mastectomy, Modified Radical

KW - Middle Aged

KW - Neoplasm Recurrence, Local/pathology

KW - Postoperative Period

KW - Radiotherapy Dosage

KW - Time Factors

M3 - Article

VL - 139

SP - 2427

EP - 2432

JO - Nederlands Tijdschrift voor Geneeskunde

JF - Nederlands Tijdschrift voor Geneeskunde

SN - 0028-2162

IS - 47

ER -