Recent developments in MEG network analysis

Arjan Hillebrand*, Cornelis J. Stam

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterAcademicpeer-review


In this chapter we will describe recent developments in magnetoencephalography (MEG) network analysis, where we will focus on the rationale behind, and application in clinical cohorts, of an atlas-based beamforming approach. This approach contains three main components, namely, (i) the reconstruction of time series of neuronal activation through beamforming; (ii) the use of a standard atlas, which enables comparisons across studies and modalities; and (iii) the estimation of functional connectivity using the phase lag index (PLI), a measure that is insensitive to the effects of field spread/volume conduction. Moreover, we will discuss the use of the minimum spanning tree (MST), which allows for a biasfree characterization of the topology of the reconstructed functional networks. Application of this approach will be illustrated through examples from recent studies in patients with gliomas, Parkinson's disease, and multiple sclerosis.

Original languageEnglish
Title of host publicationMagnetoencephalography
Subtitle of host publicationFrom Signals to Dynamic Cortical Networks: Second Edition
PublisherSpringer International Publishing AG
Number of pages287
ISBN (Electronic)9783030000875
ISBN (Print)9783030000868
Publication statusPublished - 17 Oct 2019

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